The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Björck, P.
Right arrow Articles by Kincade, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Björck, P.
Right arrow Articles by Kincade, P. W.
The Journal of Immunology, 1998, 161: 5795-5799.
Copyright © 1998 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro1

Pia Björck2 and Paul W. Kincade

Oklahoma Medical Research Foundation, Oklahoma City, OK 73104

Dendritic cells (DC) have the specific capacity of initiating primary T cell responses and ultimately derive from precursors in bone marrow. DC were originally thought to be only of myeloid origin, and myeloid precursor cells could be induced to differentiate into functional DC in response to granulocyte-macrophage (GM)-CSF. However, early CD4low precursor cells from the thymus can also develop into DC when cultured in IL-1ß, IL-3, IL-7, TNF-{alpha}, stem cell factor, and Flt-3L. In that case, GM-CSF was not required. We now show that CD19+ pro-B cells develop into DC with T cell stimulatory properties when cultured under similar conditions. These pro-B cells acquired the DC-related markers CD11c and NLDC145/DEC205, along with CD80/B7-1, CD86/B7-2, and a high density of MHC class II Ags. The marrow-derived DC did not express CD4 or CD8{alpha}, which are markers related to thymic DC. These findings are consistent with a new pathway through which DC are generated from B lymphoid precursors.




This article has been cited by other articles:


Home page
 BloodHome page
C. Rathinam and R. A. Flavell
The hematopoiesis paradigm: clarity or ambiguity?
Blood, November 1, 2008; 112(9): 3534 - 3535.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Burke, A. J. Stagg, P. A. Bedford, N. English, and S. C. Knight
IL-10-Producing B220+CD11c- APC in Mouse Spleen
J. Immunol., August 15, 2004; 173(4): 2362 - 2372.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Borghesi, L.-Y. Hsu, J. P. Miller, M. Anderson, L. Herzenberg, L. Herzenberg, M. S. Schlissel, D. Allman, and R. M. Gerstein
B Lineage-specific Regulation of V(D)J Recombinase Activity Is Established in Common Lymphoid Progenitors
J. Exp. Med., February 17, 2004; 199(4): 491 - 502.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H. Karsunky, M. Merad, A. Cozzio, I. L. Weissman, and M. G. Manz
Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
J. Exp. Med., July 21, 2003; 198(2): 305 - 313.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Reynaud, N. Lefort, E. Manie, L. Coulombel, and Y. Levy
In vitro identification of human pro-B cells that give rise to macrophages, natural killer cells, and T cells
Blood, June 1, 2003; 101(11): 4313 - 4321.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Donskoy and I. Goldschneider
Two Developmentally Distinct Populations of Dendritic Cells Inhabit the Adult Mouse Thymus: Demonstration by Differential Importation of Hematogenous Precursors Under Steady State Conditions
J. Immunol., April 1, 2003; 170(7): 3514 - 3521.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
U. Sahin, F. Neumann, O. Tureci, R. Schmits, F. Perez, and M. Pfreundschuh
Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells
Blood, December 1, 2002; 100(12): 4139 - 4145.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
I. Mikkola, B. Heavey, M. Horcher, and M. Busslinger
Reversion of B Cell Commitment upon Loss of Pax5 Expression
Science, July 5, 2002; 297(5578): 110 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Mohty, D. Isnardon, A. Charbonnier, M. Lafage-Pochitaloff, M. Merlin, D. Sainty, D. Olive, and B. Gaugler
Generation of potent Th1 responses from patients with lymphoid malignancies after differentiation of B lymphocytes into dendritic-like cells
Int. Immunol., July 1, 2002; 14(7): 741 - 750.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. R. Comeau, A.-R. Van der Vuurst de Vries, C. R. Maliszewski, and L. Galibert
CD123bright Plasmacytoid Predendritic Cells: Progenitors Undergoing Cell Fate Conversion?
J. Immunol., July 1, 2002; 169(1): 75 - 83.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
J. Yamate, K. Sato, M. Ide, M. Nakanishi, M. Kuwamura, S. Sakuma, and S. Nakatsuji
Participation of Different Macrophage Populations and Myofibroblastic Cells in Chronically Developed Renal Interstitial Fibrosis after Cisplatin-induced Renal Injury in Rats
Vet. Pathol., May 1, 2002; 39(3): 322 - 333.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Schaniel, L. Bruno, F. Melchers, and A. G. Rolink
Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones
Blood, January 15, 2002; 99(2): 472 - 478.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Bjorck
Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice
Blood, December 15, 2001; 98(13): 3520 - 3526.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H. Nakano, M. Yanagita, and M. D. Gunn
Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells
J. Exp. Med., October 15, 2001; 194(8): 1171 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
N. Kadowaki, S. Ho, S. Antonenko, R. de Waal Malefyt, R. A. Kastelein, F. Bazan, and Y.-J. Liu
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
J. Exp. Med., September 17, 2001; 194(6): 863 - 870.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Yoshida, H. Kawamoto, S. M. Santee, H. Hashi, K. Honda, S. Nishikawa, C. F. Ware, Y. Katsura, and S.-I. Nishikawa
Expression of {alpha}4{beta}7 Integrin Defines a Distinct Pathway of Lymphoid Progenitors Committed to T Cells, Fetal Intestinal Lymphotoxin Producer, NK, and Dendritic Cells
J. Immunol., September 1, 2001; 167(5): 2511 - 2521.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Izon, K. Rudd, W. DeMuth, W. S. Pear, C. Clendenin, R. C. Lindsley, and D. Allman
A Common Pathway for Dendritic Cell and Early B Cell Development
J. Immunol., August 1, 2001; 167(3): 1387 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Lu, C. A. Bonham, X. Liang, Z. Chen, W. Li, L. Wang, S. C. Watkins, M. A. Nalesnik, M. S. Schlissel, A. J. Demestris, et al.
Liver-Derived DEC205+B220+CD19- Dendritic Cells Regulate T Cell Responses
J. Immunol., June 15, 2001; 166(12): 7042 - 7052.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Q.-L. Hao, J. Zhu, M. A. Price, K. J. Payne, L. W. Barsky, and G. M. Crooks
Identification of a novel, human multilymphoid progenitor in cord blood
Blood, June 15, 2001; 97(12): 3683 - 3690.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. G. Manz, D. Traver, T. Miyamoto, I. L. Weissman, and K. Akashi
Dendritic cell potentials of early lymphoid and myeloid progenitors
Blood, June 1, 2001; 97(11): 3333 - 3341.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-K. Lee, J. K. Kim, Y. Kim, M.-K. Lee, K. Kim, J.-K. Kang, R. Hofmeister, S. K. Durum, and S. S. Han
Generation of Macrophages from Early T Progenitors In Vitro
J. Immunol., May 15, 2001; 166(10): 5964 - 5969.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Bauer, V. Redecke, J. W. Ellwart, B. Scherer, J.-P. Kremer, H. Wagner, and G. B. Lipford
Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c-, CD123+ Dendritic Cells
J. Immunol., April 15, 2001; 166(8): 5000 - 5007.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S Puch, S Armeanu, C Kibler, K. Johnson, C. Muller, M. Wheelock, and G Klein
N-cadherin is developmentally regulated and functionally involved in early hematopoietic cell differentiation
J. Cell Sci., January 4, 2001; 114(8): 1567 - 1577.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
P. J. O'Connell, A. E. Morelli, A. J. Logar, and A. W. Thomson
Phenotypic and Functional Characterization of Mouse Hepatic CD8{alpha}+ Lymphoid-Related Dendritic Cells
J. Immunol., July 15, 2000; 165(2): 795 - 803.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Galy, I. Christopherson, G. Ferlazzo, G. Liu, H. Spits, and K. Georgopoulos
Distinct signals control the hematopoiesis of lymphoid-related dendritic cells
Blood, January 1, 2000; 95(1): 128 - 137.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R.-K. Zhong, A. D. Donnenberg, H.-F. Zhang, S. Watkins, J.-H. Zhou, and E. D. Ball
Human Blood Dendritic Cell-Like B Cells Isolated by the 5G9 Monoclonal Antibody Reactive with a Novel 220-kDa Antigen
J. Immunol., August 1, 1999; 163(3): 1354 - 1362.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.