| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Pharmaceuticals Laboratory I, Yokohama Research Center, Mitsubishi Chemical Corporation, Yokohama, Japan;
Medical Research Service Department of Veterans Affairs Medical Center, Seattle, WA 98104; and Departments of
Anesthesiology,
§
Medicine, and
¶
Surgery and Physiology-Biophysics, University of Washington, Seattle, WA 98195
Leukocyte emigration and alveolar macrophage-derived cytokines may contribute to lung microvascular injury associated with adult respiratory distress syndrome. We have used mAbs against cell adhesion molecules on leukocytes (anti-CD18 and anti-CD49d) or against IL-8 to investigate these contributions. Intratracheal (i.t.) instillation of LPS (50 µg/kg) caused a significant increase in bronchoalveolar lavage polymorphonuclear leukocytes (PMNs) without an increase in mononuclear cells (MNCs) or an increase in lung permeability. Injection of LPS (10 µ/kg) i.v. at 24 h after i.t. LPS caused significant increases in bronchoalveolar lavage PMNs, MNCs, IL-8, and monocyte chemotactic protein-1, as well as increases in lung permeability. Rabbits that were administered i.t. LPS followed by i.v. LPS and treated with anti-CD18 mAb had a significantly lower lung permeability index and emigration of fewer PMNs but no change in MNC emigration compared with saline treatment. Anti-IL-8 mAb treatment resulted in a significantly lower lung permeability index with no change in PMN emigration compared with no treatment. These results suggest that PMN emigration is necessary but not sufficient for the development of LPS-induced lung injury, and that IL-8 plays a significant role in PMN-dependent lung injury, independent of PMN emigration.
This article has been cited by other articles:
|
|
 |
|
  M. L. Petreaca, M. Yao, Y. Liu, K. DeFea, and M. Martins-Green Transactivation of Vascular Endothelial Growth Factor Receptor-2 by Interleukin-8 (IL-8/CXCL8) Is Required for IL-8/CXCL8-induced Endothelial Permeability Mol. Biol. Cell, December 1, 2007; 18(12): 5014 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. Ogawa, A. Ishizaka, S. Tasaka, H. Koh, H. Ueno, F. Amaya, M. Ebina, S. Yamada, Y. Funakoshi, J. Soejima, et al. Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 400 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Hall, Y. Liu, J. M. Hickman-Davis, G. C. Davis, C. Myles, E. J. Andrews, S. Matalon, and J. D. Lang Jr. Bactericidal Function of Alveolar Macrophages in Mechanically Ventilated Rabbits Am. J. Respir. Cell Mol. Biol., June 1, 2006; 34(6): 719 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Altemeier, G. Matute-Bello, S. A. Gharib, R. W. Glenny, T. R. Martin, and W. C. Liles Modulation of Lipopolysaccharide-Induced Gene Transcription and Promotion of Lung Injury by Mechanical Ventilation J. Immunol., September 1, 2005; 175(5): 3369 - 3376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Arnold and W. Konig Respiratory Syncytial Virus Infection of Human Lung Endothelial Cells Enhances Selectively Intercellular Adhesion Molecule-1 Expression J. Immunol., June 1, 2005; 174(11): 7359 - 7367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. A. Maus, S. Wellmann, C. Hampl, W. A. Kuziel, M. Srivastava, M. Mack, M. B. Everhart, T. S. Blackwell, J. W. Christman, D. Schlondorff, et al. CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L350 - L358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Altemeier, G. Matute-Bello, C. W. Frevert, Y. Kawata, O. Kajikawa, T. R. Martin, and R. W. Glenny Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L533 - L542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Hipkin, G. Deno, J. Fine, Y. Sun, B. Wilburn, X. Fan, W. Gonsiorek, and M. T. Wiekowski Cloning and Pharmacological Characterization of CXCR1 and CXCR2 from Macaca fascicularis J. Pharmacol. Exp. Ther., July 1, 2004; 310(1): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Moriyama, A. Ishizaka, M. Nakamura, H. Kubo, T. Kotani, S. Yamamoto, E. N. Ogawa, O. Kajikawa, C. W. Frevert, Y. Kotake, et al. Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1114 - L1121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Yanagisawa, H Takano, K Inoue, T Ichinose, K Sadakane, S Yoshino, K Yamaki, Y Kumagai, K Uchiyama, T Yoshikawa, et al. Enhancement of acute lung injury related to bacterial endotoxin by components of diesel exhaust particles Thorax, July 1, 2003; 58(7): 605 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Maus, K. von Grote, W. A. Kuziel, M. Mack, E. J. Miller, J. Cihak, M. Stangassinger, R. Maus, D. Schlondorff, W. Seeger, et al. The Role of CC Chemokine Receptor 2 in Alveolar Monocyte and Neutrophil Immigration in Intact Mice Am. J. Respir. Crit. Care Med., August 1, 2002; 166(3): 268 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Frevert, R. B. Goodman, M. G. Kinsella, O. Kajikawa, K. Ballman, I. Clark-Lewis, A. E. I. Proudfoot, T. N. C. Wells, and T. R. Martin Tissue-Specific Mechanisms Control the Retention of IL-8 in Lungs and Skin J. Immunol., April 1, 2002; 168(7): 3550 - 3556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-p. Gao, N. Xu, M. Sekosan, D. Mehta, S. Y. Ma, A. Rahman, and A. B. Malik Differential Role of CD18 Integrins in Mediating Lung Neutrophil Sequestration and Increased Microvascular Permeability Induced by Escherichia coli in Mice J. Immunol., September 1, 2001; 167(5): 2895 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. U. Schraufstatter, J. Chung, and M. Burger IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1094 - L1103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lefort, L. Motreff, and B. Boris Vargaftig Airway Administration of Escherichia coli Endotoxin to Mice Induces Glucocorticosteroid-Resistant Bronchoconstriction and Vasopermeation Am. J. Respir. Cell Mol. Biol., March 1, 2001; 24(3): 345 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Ali, S. A. Schlidt, N. S. Chandel, K. L. Hynes, P. T. Schumacker, and B. L. Gewertz Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction Am J Physiol Lung Cell Mol Physiol, November 1, 1999; 277(5): L1057 - L1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. A. Maus, M. A. Koay, T. Delbeck, M. Mack, M. Ermert, L. Ermert, T. S. Blackwell, J. W. Christman, D. Schlondorff, W. Seeger, et al. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1245 - L1252. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
