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The Journal of Immunology, 1998, 161: 5430-5437.
Copyright © 1998 by The American Association of Immunologists

IL-2R{alpha} on One Cell Can Present IL-2 to IL-2Rß/{gamma}c on Another Cell to Augment IL-2 Signaling

Donald M. Eicher1 and Thomas A. Waldmann

Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

IL-2R{alpha} augments IL-2 signaling. Although this is generally believed to occur only when the three known components of IL-2R are associated within a single cell membrane, we demonstrate here an intercellular interaction. Cocultivation of cells individually expressing chimerae incorporating the extracellular domain of IL-2R{alpha} alone with cells expressing chimerae of IL-2Rß alone permitted IL-2 dose-dependent oligomerization of the chimerae. Likewise, native IL-2R{alpha}-bearing cells augmented the IL-2 proliferative response of ex vivo large granular lymphocytic leukemia cells expressing IL-2Rß/{gamma}c but lacking IL-2R{alpha}. In both cases, the response was inhibitable by an Ab to IL-2R{alpha}. Intercellular augmentation of cytokine effects, acting in trans, has important implications for biology and medicine.




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