|
|
||||||||

*
R. W. Johnson Pharmaceutical Research Institute, San Diego, CA 92121; and
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037
In the absence of costimulation, TCR recognition of peptide/MHC complexes is generally considered to be nonimmunogenic. In agreement with this view, naive TCR transgenic CD8+ cells failed to respond to specific peptides presented by MHC class I (Ld) molecules bound to mouse RBC. However, peptide/Ld complexes presented by cell-sized beads or bound to plastic led to overt proliferative responses in the absence of added cytokines. Significantly, equivalent strong proliferative responses occurred when mouse RBC were fixed with glutaraldehyde before Ld coupling. The implication therefore is that the intensity of signaling via the TCR is a reflection of the mobility of the ligand being recognized; TCR signaling is weak when the ligand can move laterally on the cell membrane but strong when the ligand is immobilized.
This article has been cited by other articles:
![]() |
S. Walter, L. Herrgen, O. Schoor, G. Jung, D. Wernet, H.-J. Buhring, H.-G. Rammensee, and S. Stevanovic Cutting Edge: Predetermined Avidity of Human CD8 T Cells Expanded on Calibrated MHC/Anti-CD28-Coated Microspheres J. Immunol., November 15, 2003; 171(10): 4974 - 4978. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. H. Schafer, A. K. Gandhi, M. A. Loveland, R. S. Chen, H.-W. Man, P. P. M. Schnetkamp, G. Wolbring, S. Govinda, L. G. Corral, F. Payvandi, et al. Enhancement of Cytokine Production and AP-1 Transcriptional Activity in T Cells by Thalidomide-Related Immunomodulatory Drugs J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 1222 - 1232. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Hwang, X. Shen, and J. Sprent Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules PNAS, May 27, 2003; 100(11): 6670 - 6675. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Zhai, L. Meng, F. Gao, R. W. Busuttil, and J. W. Kupiec-Weglinski Allograft Rejection by Primed/Memory CD8+ T Cells Is CD154 Blockade Resistant: Therapeutic Implications for Sensitized Transplant Recipients J. Immunol., October 15, 2002; 169(8): 4667 - 4673. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. D. Brown and D. Lillicrap Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy Blood, July 30, 2002; 100(4): 1133 - 1140. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-W. Mittrucker, M. Kursar, A. Kohler, R. Hurwitz, and S. H. E. Kaufmann Role of CD28 for the Generation and Expansion of Antigen-Specific CD8+ T Lymphocytes During Infection with Listeria monocytogenes J. Immunol., November 15, 2001; 167(10): 5620 - 5627. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Hwang and J. Sprent Role of the Actin Cytoskeleton in T Cell Absorption and Internalization of Ligands from APC J. Immunol., April 15, 2001; 166(8): 5099 - 5107. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Slavik, D.-G. Lim, S. J. Burakoff, and D. A. Hafler Uncoupling p70s6 Kinase Activation and Proliferation: Rapamycin-Resistant Proliferation of Human CD8+ T Lymphocytes J. Immunol., March 1, 2001; 166(5): 3201 - 3209. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Zhan, A. J. Corbett, J. L. Brady, R. M. Sutherland, and A. M. Lew CD4 Help-Independent Induction of Cytotoxic CD8 Cells to Allogeneic P815 Tumor Cells Is Absolutely Dependent on Costimulation J. Immunol., October 1, 2000; 165(7): 3612 - 3619. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. R. Rogers and M. Croft CD28, Ox-40, LFA-1, and CD4 Modulation of Th1/Th2 Differentiation Is Directly Dependent on the Dose of Antigen J. Immunol., March 15, 2000; 164(6): 2955 - 2963. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. W. Bingaman, J. Ha, S.-Y. Waitze, M. M. Durham, H. R. Cho, C. Tucker-Burden, R. Hendrix, S. R. Cowan, T. C. Pearson, and C. P. Larsen Vigorous Allograft Rejection in the Absence of Danger J. Immunol., March 15, 2000; 164(6): 3065 - 3071. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Sprent Presidential Address to The American Association of Immunologists : Stimulating Naive T Cells J. Immunol., November 1, 1999; 163(9): 4629 - 4636. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Sepulveda, A. Cerwenka, T. Morgan, and R. W. Dutton CD28, IL-2-Independent Costimulatory Pathways for CD8 T Lymphocyte Activation J. Immunol., August 1, 1999; 163(3): 1133 - 1142. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Hauser, F. Zipprich, I. Leblond, S. Wirth, and A. W. Hugin Protective Immunity from Naive CD8+ T Cells Activated In Vitro with MHC Class I Binding Immunogenic Peptides and IL-2 in the Absence of Specialized APCs J. Immunol., July 1, 1999; 163(1): 330 - 336. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |