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CUTTING EDGE |
*
Roche Milano Ricerche, Milan, Italy; and
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Polarized Th1 and Th2 cells differentially express adhesion molecules and chemokine receptors, endowing these cells with distinct tissue homing capabilities. Here we report that, in contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. IL-4 is not required for this activation-induced up-regulation of CCR4 and CCR8. In accordance with receptor expression, the response of Th2 cells to I-309 (CCR8 ligand) and thymus- and activation-regulated chemokine (CCR4 and CCR8 ligand) is enhanced upon activation. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Analysis of polarized subsets of CD8+ T cells reveals a similar pattern of chemokine receptor expression and modulation of responsiveness. Taken together, these findings suggest that an up-regulation of CCR4 and CCR8 following Ag encounter may contribute to the proper positioning of activated T cells within sites of antigenic challenge and/or specialized areas of lymphoid tissues.
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|
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|
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D. D'AMBROSIO, M. MARIANI, P. PANINA-BORDIGNON, and F. SINIGAGLIA Chemokines and Their Receptors Guiding T Lymphocyte Recruitment in Lung Inflammation Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1266 - 1275. [Full Text] [PDF]
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A. Iellem, M. Mariani, R. Lang, H. Recalde, P. Panina-Bordignon, F. Sinigaglia, and D. D'Ambrosio Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells J. Exp. Med., September 17, 2001; 194(6): 847 - 854. [Abstract] [Full Text] [PDF]
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T. Chtanova, R. A. Kemp, A. P. R. Sutherland, F. Ronchese, and C. R. Mackay Gene Microarrays Reveal Extensive Differential Gene Expression in Both CD4+ and CD8+ Type 1 and Type 2 T Cells J. Immunol., September 15, 2001; 167(6): 3057 - 3063. [Abstract] [Full Text] [PDF]
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H. R. Luttichau, J. Gerstoft, and T. W. Schwartz MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8 J. Leukoc. Biol., August 1, 2001; 70(2): 277 - 282. [Abstract] [Full Text] [PDF]
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P. Ghia, P. Transidico, J. P. Veiga, C. Schaniel, F. Sallusto, K. Matsushima, S. E. Sallan, A. G. Rolink, A. Mantovani, L. M. Nadler, et al. Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells Blood, August 1, 2001; 98(3): 533 - 540. [Abstract] [Full Text] [PDF]
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M. J. Dobrzanski, J. B. Reome, and R. W. Dutton Role of Effector Cell-Derived IL-4, IL-5, and Perforin in Early and Late Stages of Type 2 CD8 Effector Cell-Mediated Tumor Rejection J. Immunol., July 1, 2001; 167(1): 424 - 434. [Abstract] [Full Text] [PDF]
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 M. C. Berin, M. B. Dwinell, L. Eckmann, and M. F. Kagnoff Production of MDC/CCL22 by human intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1217 - G1226. [Abstract] [Full Text] [PDF]
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 M. Cecilia Berin, L. Eckmann, D. H. Broide, and M. F. Kagnoff Regulated Production of the T Helper 2-Type T-Cell Chemoattractant TARC by Human Bronchial Epithelial Cells In Vitro and in Human Lung Xenografts Am. J. Respir. Cell Mol. Biol., April 1, 2001; 24(4): 382 - 389. [Abstract] [Full Text]
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F. Katou, H. Ohtani, T. Nakayama, K. Ono, K. Matsushima, A. Saaristo, H. Nagura, O. Yoshie, and K. Motegi Macrophage-Derived Chemokine (MDC/CCL22) and CCR4 Are Involved in the Formation of T Lymphocyte-Dendritic Cell Clusters in Human Inflamed Skin and Secondary Lymphoid Tissue Am. J. Pathol., April 1, 2001; 158(4): 1263 - 1270. [Abstract] [Full Text] [PDF]
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S. W. Chensue, N. W. Lukacs, T.-Y. Yang, X. Shang, K. A. Frait, S. L. Kunkel, T. Kung, M. T. Wiekowski, J. A. Hedrick, D. N. Cook, et al. Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice J. Exp. Med., March 5, 2001; 193(5): 573 - 584. [Abstract] [Full Text] [PDF]
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O. Fahy, H. Porte, S. Senechal, H. Vorng, A. R. McEuen, M. G. Buckley, A. F. Walls, B. Wallaert, A.-B. Tonnel, and A. Tsicopoulos Chemokine-Induced Cutaneous Inflammatory Cell Infiltration in a Model of Hu-PBMC-SCID Mice Grafted with Human Skin Am. J. Pathol., March 1, 2001; 158(3): 1053 - 1063. [Abstract] [Full Text] [PDF]
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S. J. Till, L. A. Jopling, P. A. Wachholz, R. L. Robson, S. Qin, D. P. Andrew, L. Wu, J. van Neerven, T. J. Williams, S. R. Durham, et al. T Cell Phenotypes of the Normal Nasal Mucosa: Induction of Th2 Cytokines and CCR3 Expression by IL-4 J. Immunol., February 15, 2001; 166(4): 2303 - 2310. [Abstract] [Full Text] [PDF]
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S. Sebastiani, P. Allavena, C. Albanesi, F. Nasorri, G. Bianchi, C. Traidl, S. Sozzani, G. Girolomoni, and A. Cavani Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity J. Immunol., January 15, 2001; 166(2): 996 - 1002. [Abstract] [Full Text] [PDF]
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L. Kremer, L. Carramolino, I. Goya, A. Zaballos, J. Gutierrez, M. del Carmen Moreno-Ortiz, C. Martinez-A., and G. Marquez The Transient Expression of C-C Chemokine Receptor 8 in Thymus Identifies a Thymocyte Subset Committed to Become CD4+ Single-Positive T Cells J. Immunol., January 1, 2001; 166(1): 218 - 225. [Abstract] [Full Text] [PDF]
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N. S. Haque, J. T. Fallon, M. B. Taubman, and P. C. Harpel The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium Blood, January 1, 2001; 97(1): 39 - 45. [Abstract] [Full Text] [PDF]
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F. SINIGAGLIA and D. D'AMBROSIO Regulation of Helper T Cell Differentiation and Recruitment in Airway Inflammation Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): S157 - 160. [Abstract] [Full Text] [PDF]
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A. Mantovani, P. A. Gray, J. Van Damme, and S. Sozzani Macrophage-derived chemokine (MDC) J. Leukoc. Biol., September 1, 2000; 68(3): 400 - 404. [Abstract] [Full Text] [PDF]
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 N. S. Haque, X. Zhang, D. L. French, J. Li, M. Poon, J. T. Fallon, B. R. Gabel, M. B. Taubman, M. Koschinsky, and P. C. Harpel CC Chemokine I-309 Is the Principal Monocyte Chemoattractant Induced by Apolipoprotein(a) in Human Vascular Endothelial Cells Circulation, August 15, 2000; 102(7): 786 - 792. [Abstract] [Full Text] [PDF]
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 L. H. Glimcher and K. M. Murphy Lineage commitment in the immune system: the T helper lymphocyte grows up Genes & Dev., July 15, 2000; 14(14): 1693 - 1711. [Full Text]
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D. Jones, C. O'Hara, M. D. Kraus, A. R. Perez-Atayde, A. Shahsafaei, L. Wu, and D. M. Dorfman Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma Blood, July 15, 2000; 96(2): 685 - 690. [Abstract] [Full Text] [PDF]
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C. Chizzolini, R. Rezzonico, C. De Luca, D. Burger, and J.-M. Dayer Th2 Cell Membrane Factors in Association with IL-4 Enhance Matrix Metalloproteinase-1 (MMP-1) While Decreasing MMP-9 Production by Granulocyte-Macrophage Colony-Stimulating Factor-Differentiated Human Monocytes J. Immunol., June 1, 2000; 164(11): 5952 - 5960. [Abstract] [Full Text] [PDF]
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Y. Chvatchko, A. J. Hoogewerf, A. Meyer, S. Alouani, P. Juillard, R. Buser, F. Conquet, A. E.I. Proudfoot, T. N.C. Wells, and C. A. Power A Key Role for Cc Chemokine Receptor 4 in Lipopolysaccharide-Induced Endotoxic Shock J. Exp. Med., May 15, 2000; 191(10): 1755 - 1764. [Abstract] [Full Text] [PDF]
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C. Murdoch and A. Finn Chemokine receptors and their role in inflammation and infectious diseases Blood, May 15, 2000; 95(10): 3032 - 3043. [Abstract] [Full Text] [PDF]
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B. Clissi, D. D'Ambrosio, J. Geginat, L. Colantonio, A. Morrot, N. W. Freshney, J. Downward, F. Sinigaglia, and R. Pardi Chemokines Fail to Up-Regulate {beta}1 Integrin-Dependent Adhesion in Human Th2 T Lymphocytes J. Immunol., March 15, 2000; 164(6): 3292 - 3300. [Abstract] [Full Text] [PDF]
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J. T. Stine, C. Wood, M. Hill, A. Epp, C. J. Raport, V. L. Schweickart, Y. Endo, T. Sasaki, G. Simmons, C. Boshoff, et al. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells Blood, February 15, 2000; 95(4): 1151 - 1157. [Abstract] [Full Text] [PDF]
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C. M. Lloyd, T. Delaney, T. Nguyen, J. Tian, C. Martinez-A, A. J. Coyle, and J.-C. Gutierrez-Ramos Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo J. Exp. Med., January 17, 2000; 191(2): 265 - 274. [Abstract] [Full Text] [PDF]
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H. R. Luttichau, J. Stine, T. P. Boesen, A. H. Johnsen, D. Chantry, J. Gerstoft, and T. W. Schwartz A Highly Selective Cc Chemokine Receptor (Ccr)8 Antagonist Encoded by the Poxvirus Molluscum Contagiosum J. Exp. Med., January 3, 2000; 191(1): 171 - 180. [Abstract] [Full Text] [PDF]
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N. Sato, W. A. Kuziel, P. C. Melby, R. L. Reddick, V. Kostecki, W. Zhao, N. Maeda, S. K. Ahuja, and S. S. Ahuja Defects in the Generation of IFN-{gamma} Are Overcome to Control Infection with Leishmania donovani in CC Chemokine Receptor (CCR) 5-, Macrophage Inflammatory Protein-1{alpha}-, or CCR2-Deficient Mice J. Immunol., November 15, 1999; 163(10): 5519 - 5525. [Abstract] [Full Text] [PDF]
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L. Colantonio, A. Iellem, B. Clissi, R. Pardi, L. Rogge, F. Sinigaglia, and D. D'Ambrosio Upregulation of Integrin alpha 6/beta 1 and Chemokine Receptor CCR1 by Interleukin-12 Promotes the Migration of Human Type 1 Helper T Cells Blood, November 1, 1999; 94(9): 2981 - 2989. [Abstract] [Full Text] [PDF]
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D. J. Dairaghi, R. A. Fan, B. E. McMaster, M. R. Hanley, and T. J. Schall HHV8-encoded vMIP-I Selectively Engages Chemokine Receptor CCR8. AGONIST AND ANTAGONIST PROFILES OF VIRAL CHEMOKINES J. Biol. Chem., July 30, 1999; 274(31): 21569 - 21574. [Abstract] [Full Text] [PDF]
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M. J. Endres, C. G. Garlisi, H. Xiao, L. Shan, and J. A. Hedrick The Kaposi's Sarcoma-related Herpesvirus (KSHV)-encoded Chemokine vMIP-I is a Specific Agonist for the CC Chemokine Receptor (CCR)8 J. Exp. Med., June 21, 1999; 189(12): 1993 - 1998. [Abstract] [Full Text] [PDF]
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