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The Journal of Immunology, 1998, 161: 7-10.
Copyright © 1998 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Ly-49D and Ly-49H Associate with Mouse DAP12 and Form Activating Receptors1

Kathleen M. Smith2, Jun Wu, Alexander B. H. Bakker, Joseph H. Phillips and Lewis L. Lanier

DNAX Research Institute, Palo Alto, CA 94304

Several members of the Ly-49 receptor family inhibit NK cell-mediated lysis of targets expressing appropriate MHC class I molecules. Ly-49D and Ly-49H, two Ly-49 molecules that lack immunoreceptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic domains, associate with mouse DAP12, a molecule that possesses an immunoreceptor tyrosine-based activation motif (ITAM). Cotransfection of either Ly-49D or Ly-49H with DAP12 induces surface expression of both Ly-49 and DAP12. The Ly-49/DAP12 complex was coimmunoprecipitated from the transfected cells, demonstrating a physical association of DAP12 with Ly-49D or Ly-49H in the plasma membrane. Stimulation of transfectants with Abs recognizing either Ly-49D or Ly-49H results in cellular activation, as assessed by induction of tyrosine phosphorylation of multiple cellular substrates.




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J. Dietrich, M. Cella, M. Seiffert, H.-J. Buhring, and M. Colonna
Cutting Edge: Signal-Regulatory Protein {beta}1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells
J. Immunol., January 1, 2000; 164(1): 9 - 12.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
S. Korten, E. Wilk, J. E. Gessner, D. Meyer, and R. E. Schmidt
Altered Donor and Recipient Ly49+ NK Cell Subsets in Allogeneic H-2d -> H-2b and H-2b -> H-2d Bone Marrow Chimeras
J. Immunol., December 1, 1999; 163(11): 5896 - 5905.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. R. Ortaldo, R. Winkler-Pickett, J. Willette-Brown, R. L. Wange, S. K. Anderson, G. J. Palumbo, L. H. Mason, and D. W. McVicar
Structure/Function Relationship of Activating Ly-49D and Inhibitory Ly-49G2 NK Receptors ,2
J. Immunol., November 15, 1999; 163(10): 5269 - 5277.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. C. Nakamura, C. Naper, E. C. Niemi, S. C. Spusta, B. Rolstad, G. W. Butcher, W. E. Seaman, and J. C. Ryan
Natural Killing of Xenogeneic Cells Mediated by the Mouse Ly-49D Receptor
J. Immunol., November 1, 1999; 163(9): 4694 - 4700.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
A. P. Makrigiannis, P. Gosselin, L. H. Mason, L. S. Taylor, D. W. McVicar, J. R. Ortaldo, and S. K. Anderson
Cloning and Characterization of a Novel Activating Ly49 Closely Related to Ly49A ,2 ,3
J. Immunol., November 1, 1999; 163(9): 4931 - 4938.
[Abstract] [Full Text] [PDF]

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 Int ImmunolHome page
C. Depatie, A. Chalifour, C. Pare, S.-H. Lee, S. M. Vidal, and S. Lemieux3
Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets
Int. Immunol., September 1, 1999; 11(9): 1541 - 1551.
[Abstract] [Full Text] [PDF]

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 BloodHome page
L. S. Taylor and D. W. McVicar
Functional Association of Fcvarepsilon RIgamma With Arginine632 of Paired Immunoglobulin-Like Receptor (PIR)-A3 in Murine Macrophages
Blood, September 1, 1999; 94(5): 1790 - 1796.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
A. B. H. Bakker, E. Baker, G. R. Sutherland, J. H. Phillips, and L. L. Lanier
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells
PNAS, August 17, 1999; 96(17): 9792 - 9796.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
T. C. George, J. R. Ortaldo, S. Lemieux, V. Kumar, and M. Bennett
Tolerance and Alloreactivity of the Ly49D Subset of Murine NK Cells
J. Immunol., August 15, 1999; 163(4): 1859 - 1867.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
A. Kubota, S. Kubota, S. Lohwasser, D. L. Mager, and F. Takei
Diversity of NK Cell Receptor Repertoire in Adult and Neonatal Mice
J. Immunol., July 1, 1999; 163(1): 212 - 216.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
A. H. Idris, H. R. C. Smith, L. H. Mason, J. R. Ortaldo, A. A. Scalzo, and W. M. Yokoyama
The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing
PNAS, May 25, 1999; 96(11): 6330 - 6335.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. R. Carlyle, A. Martin, A. Mehra, L. Attisano, F. W. Tsui, and J. C. Zuniga-Pflucker
Mouse NKR-P1B, a Novel NK1.1 Antigen with Inhibitory Function
J. Immunol., May 15, 1999; 162(10): 5917 - 5923.
[Abstract] [Full Text] [PDF]

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 JEMHome page
S. Rajagopalan and E. O. Long
A Human Histocompatibility Leukocyte Antigen (HLA)-G-specific Receptor Expressed on All Natural Killer Cells
J. Exp. Med., April 5, 1999; 189(7): 1093 - 1100.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
K. Bernard, A. Cambiaggi, S. Guia, F. Bertucci, S. Granjeaud, R. Tagett, C. N'Guyen, B. R. Jordan, and E. Vivier
Engagement of Natural Cytotoxicity Programs Regulates AP-1 Expression in the NKL Human NK Cell Line
J. Immunol., April 1, 1999; 162(7): 4062 - 4068.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
H. Nakajima, J. Samaridis, L. Angman, and M. Colonna
Cutting Edge: Human Myeloid Cells Express an Activating ILT Receptor (ILT1) That Associates with Fc Receptor {gamma}-Chain
J. Immunol., January 1, 1999; 162(1): 5 - 8.
[Abstract] [Full Text] [PDF]

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 JEMHome page
A. H. Idris, K. Iizuka, H. R.C. Smith, A. A. Scalzo, and W. M. Yokoyama
Genetic Control Of Natural Killing and In Vivo Tumor Elimination by the Chok Locus
J. Exp. Med., December 21, 1998; 188(12): 2243 - 2256.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. Tomasello, L. Olcese, F. Vely, C. Geourgeon, M. Blery, A. Moqrich, D. Gautheret, M. Djabali, M.-G. Mattei, and E. Vivier
Gene Structure, Expression Pattern, and Biological Activity of Mouse Killer Cell Activating Receptor-associated Protein (KARAP)/DAP-12
J. Biol. Chem., December 18, 1998; 273(51): 34115 - 34119.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. W. McVicar, L. S. Taylor, P. Gosselin, J. Willette-Brown, A. I. Mikhael, R. L. Geahlen, M. C. Nakamura, P. Linnemeyer, W. E. Seaman, S. K. Anderson, et al.
DAP12-mediated Signal Transduction in Natural Killer Cells. A DOMINANT ROLE FOR THE Syk PROTEIN-TYROSINE KINASE
J. Biol. Chem., December 4, 1998; 273(49): 32934 - 32942.
[Abstract] [Full Text] [PDF]


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