| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom;
Institute of Endemic Diseases and
Department of Biochemistry, University of Khartoum, Sudan;
§
Centre for Medical Parasitology at Institute of Medical Microbiology and Immunology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark; and
¶
National Institute for Medical Research, The Ridgeway, London, United Kingdom
Merozoite surface protein-1 (MSP-1) of Plasmodium falciparum is a malaria vaccine candidate Ag. Immunity to MSP-1 has been implicated in protection against infection in animal models. However, MSP-1 is a polymorphic protein and its immune recognition by humans following infection is not well understood. We have compared the immunogenicity of conserved and polymorphic regions of MSP-1, the specificity of Ab responses to a polymorphic region of the Ag, and the duration of these responses in Sudanese villagers intermittently exposed to P. falciparum infections. Recombinant Ags representing the conserved N terminus (Block 1), the conserved C terminus, and the three main types of the major polymorphic region (Block 2) of MSP-1 were used to determine the specificity and longitudinal patterns of IgG Ab responses to MSP-1 in individuals. Abs from 52 donors were assessed before, during, and after malaria transmission seasons for 4 yr. Ags from the Block 1 region were rarely recognized by any donor. Responses to the C-terminal Ag occurred in the majority of acutely infected individuals and thus were a reliable indicator of recent clinical infection. Ags from the polymorphic Block 2 region of MSP-1 were recognized by many, although not all individuals after clinical malaria infections. Responses to Block 2 were type specific and correlated with PCR typing of parasites present at the time of infection. Responses to all of these Ags declined within a few months of drug treatment and parasite clearance, indicating that naturally induced human Ab responses to MSP-1 are short lived.
This article has been cited by other articles:
|
|
 |
|
  F. H. A. Osier, G. Fegan, S. D. Polley, L. Murungi, F. Verra, K. K. A. Tetteh, B. Lowe, T. Mwangi, P. C. Bull, A. W. Thomas, et al. Breadth and Magnitude of Antibody Responses to Multiple Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Clinical Malaria Infect. Immun., May 1, 2008; 76(5): 2240 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Akpogheneta, N. O. Duah, K. K. A. Tetteh, S. Dunyo, D. E. Lanar, M. Pinder, and D. J. Conway Duration of Naturally Acquired Antibody Responses to Blood-Stage Plasmodium falciparum Is Age Dependent and Antigen Specific Infect. Immun., April 1, 2008; 76(4): 1748 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. A. Lusingu, A. T. R. Jensen, L. S. Vestergaard, D. T. Minja, M. B. Dalgaard, S. Gesase, B. P. Mmbando, A. Y. Kitua, M. M. Lemnge, D. Cavanagh, et al. Levels of Plasma Immunoglobulin G with Specificity against the Cysteine-Rich Interdomain Regions of a Semiconserved Plasmodium falciparum Erythrocyte Membrane Protein 1, VAR4, Predict Protection against Malarial Anemia and Febrile Episodes. Infect. Immun., May 1, 2006; 74(5): 2867 - 2875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pinder, C. J. Sutherland, F. Sisay-Joof, J. Ismaili, M. B. B. McCall, R. Ord, R. Hallett, A. A. Holder, and P. Milligan Immunoglobulin G Antibodies to Merozoite Surface Antigens Are Associated with Recovery from Chloroquine-Resistant Plasmodium falciparum in Gambian Children. Infect. Immun., May 1, 2006; 74(5): 2887 - 2893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. A. Tetteh, D. R. Cavanagh, P. Corran, R. Musonda, J. S. McBride, and D. J. Conway Extensive Antigenic Polymorphism within the Repeat Sequence of the Plasmodium falciparum Merozoite Surface Protein 1 Block 2 Is Incorporated in a Minimal Polyvalent Immunogen Infect. Immun., September 1, 2005; 73(9): 5928 - 5935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Drakeley, P. H. Corran, P. G. Coleman, J. E. Tongren, S. L. R. McDonald, I. Carneiro, R. Malima, J. Lusingu, A. Manjurano, W. M. M. Nkya, et al. Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure PNAS, April 5, 2005; 102(14): 5108 - 5113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Urban, T. T. Hien, N. P. Day, N. H. Phu, R. Roberts, E. Pongponratn, M. Jones, N. T. H. Mai, D. Bethell, G. D. H. Turner, et al. Fatal Plasmodium falciparum Malaria Causes Specific Patterns of Splenic Architectural Disorganization Infect. Immun., April 1, 2005; 73(4): 1986 - 1994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. T. SHIGIDI, R. A. HASHIM, M. N. A. IDRIS, M. M. MUKHTAR, and T.-E. O. SOKRAB PARASITE DIVERSITY IN ADULT PATIENTS WITH CEREBRAL MALARIA: A HOSPITAL-BASED, CASE-CONTROL STUDY Am J Trop Med Hyg, December 1, 2004; 71(6): 754 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. U. Ferreira, M. da Silva Nunes, and G. Wunderlich Antigenic Diversity and Immune Evasion by Malaria Parasites Clin. Vaccine Immunol., November 1, 2004; 11(6): 987 - 995. [Full Text] [PDF]
|
|
|
|
|
|
D. R. Cavanagh, D. Dodoo, L. Hviid, J. A. L. Kurtzhals, T. G. Theander, B. D. Akanmori, S. Polley, D. J. Conway, K. Koram, and J. S. McBride Antibodies to the N-Terminal Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Associated with Protection against Clinical Malaria Infect. Immun., November 1, 2004; 72(11): 6492 - 6502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Achtman, M. Khan, I. C. M. MacLennan, and J. Langhorne Plasmodium chabaudi chabaudi Infection in Mice Induces Strong B Cell Responses and Striking But Temporary Changes in Splenic Cell Distribution J. Immunol., July 1, 2003; 171(1): 317 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Polley, K. K. A. Tetteh, D. R. Cavanagh, R. J. Pearce, J. M. Lloyd, K. A. Bojang, D. M. N. Okenu, B. M. Greenwood, J. S. McBride, and D. J. Conway Repeat Sequences in Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Targets of Antibodies Associated with Protection from Malaria Infect. Immun., April 1, 2003; 71(4): 1833 - 1842. [Abstract] [Full Text]
|
|
|
|
|
|
O. H. Branch, S. Takala, S. Kariuki, B. L. Nahlen, M. Kolczak, W. Hawley, and A. A. Lal Plasmodium falciparum Genotypes, Low Complexity of Infection, and Resistance to Subsequent Malaria in Participants in the Asembo Bay Cohort Project Infect. Immun., December 1, 2001; 69(12): 7783 - 7792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Urban, T. Mwangi, A. Ross, S. Kinyanjui, M. Mosobo, O. Kai, B. Lowe, K. Marsh, and D. J. Roberts Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria Blood, November 1, 2001; 98(9): 2859 - 2861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Urban, N. Willcox, and D. J. Roberts A role for CD36 in the regulation of dendritic cell function PNAS, July 5, 2001; (2001) 151028698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, T. L. Richie, A. Stowers, D. H. Nhan, and R. L. Coppel Naturally Acquired Antibody Responses to Plasmodium falciparum Merozoite Surface Protein 4 in a Population Living in an Area of Endemicity in Vietnam Infect. Immun., July 1, 2001; 69(7): 4390 - 4397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Quin and J. Langhorne Different Regions of the Malaria Merozoite Surface Protein 1 of Plasmodium chabaudi Elicit Distinct T-Cell and Antibody Isotype Responses Infect. Immun., April 1, 2001; 69(4): 2245 - 2251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Cavanagh, C. Dobano, I. M. Elhassan, K. Marsh, A. Elhassan, L. Hviid, E. A. T. G. Khalil, T. G. Theander, D. E. Arnot, and J. S. McBride Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum Infect. Immun., February 1, 2001; 69(2): 1207 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. John, P. O. Sumba, J. H. Ouma, B. L. Nahlen, C. L. King, and J. W. Kazura Cytokine Responses to Plasmodium falciparum Liver-Stage Antigen 1 Vary in Rainy and Dry Seasons in Highland Kenya Infect. Immun., September 1, 2000; 68(9): 5198 - 5204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Da Silveira, M. L. Dorta, E. A. S. Kimura, A. M. Katzin, F. Kawamoto, K. Tanabe, and M. U. Ferreira Allelic Diversity and Antibody Recognition of Plasmodium falciparum Merozoite Surface Protein 1 during Hypoendemic Malaria Transmission in the Brazilian Amazon Region Infect. Immun., November 1, 1999; 67(11): 5906 - 5916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Giha, T. Staalsoe, D. Dodoo, I. M. Elhassan, C. Roper, G. M. H. Satti, D. E. Arnot, T. G. Theander, and L. Hviid Nine-Year Longitudinal Study of Antibodies to Variant Antigens on the Surface of Plasmodium falciparum-Infected Erythrocytes Infect. Immun., August 1, 1999; 67(8): 4092 - 4098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Fonjungo, I. M. Elhassan, D. R. Cavanagh, T. G. Theander, L. Hviid, C. Roper, D. E. Arnot, and J. S. McBride A Longitudinal Study of Human Antibody Responses to Plasmodium falciparum Rhoptry-Associated Protein 1 in a Region of Seasonal and Unstable Malaria Transmission Infect. Immun., June 1, 1999; 67(6): 2975 - 2985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dodoo, T. G. Theander, J. A. L. Kurtzhals, K. Koram, E. Riley, B. D. Akanmori, F. K. Nkrumah, and L. Hviid Levels of Antibody to Conserved Parts of Plasmodium falciparum Merozoite Surface Protein 1 in Ghanaian Children Are Not Associated with Protection from Clinical Malaria Infect. Immun., May 1, 1999; 67(5): 2131 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Urban, N. Willcox, and D. J. Roberts A role for CD36 in the regulation of dendritic cell function PNAS, July 17, 2001; 98(15): 8750 - 8755. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
