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*
Department of Biology, Thomas More College, Crestview Hills, KY 41017;
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267
Previous studies have suggested that oral tolerance induction by
low doses of Ag is mediated by inhibitory cytokines, particularly
TGF-ß1. To examine the roles of TGF-ß1 and other inhibitory
cytokines in the induction of oral tolerance, TGF-ß1 null mice and
controls were gavaged with 10 to 20 mg (high dose) or 1 mg (low dose)
of OVA for 3 days. After immunization with OVA, the in vitro
proliferative response of OVA-specific popliteal lymph node cells was
assessed. Lymphocytes from all TGF-ß1 null mice fed high doses of OVA
exhibited highly significant suppression compared with controls. A
weaker, but still significant, suppression was observed in lymphocytes
from the majority of TGF-ß1 null mice fed low doses of OVA. In
addition, supernatants from these lymphocytes exhibited lower levels of
IL-4, IL-10, and IFN-
than those from water-fed control animals.
These results indicate that while TGF-ß1 may play a role in
suppression, inhibitory cytokines are not the exclusive mechanism by
which low dose oral tolerance is induced.
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