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The Journal of Immunology, 1998, 161: 11-16.
Copyright © 1998 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: The Expression In Vivo of a Second Isoform of pT{alpha}: Implications for the Mechanism of pT{alpha} Action1

Domingo F. Barber*, Lorena Passoni2,*, Li Wen2,3,*, Liping Geng* and Adrian C. Hayday4,*,{dagger}

* Department of Molecular, Cell & Developmental Biology and {dagger} Section of Immunobiology, Yale University, New Haven, CT 06520

A second isoform of pT{alpha}, "pT{alpha}b," is derived from the pT{alpha} locus by tissue-specific, alternative splicing. pT{alpha}b is coexpressed in the thymus with the previously characterized form of pT{alpha} (which we term pT{alpha}a) and is also expressed in peripheral cells without pT{alpha}a. While pT{alpha}a acts to retain most TCR ß-chains intracellularly, pT{alpha}b permits higher levels of cell surface TCRß expression and facilitates signaling from a CD3-TCRß complex.




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