| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;
Biomedical Research Institute, Rockville, MD 20852; and
Institute for Genetics, University of Cologne, Weyertal, Cologne, Germany
We have used IL-10 gene knockout mice (IL-10T) to examine the role
of endogenous IL-10 in the down-modulation of hepatic granuloma
formation and lymphocyte responses that occurs in chronic infection
with the helminth parasite Schistosoma mansoni. Although
IL-10-deficient animals showed 20 to 30% mortality between 8 and 14 wk
postinfection, they displayed no alterations in their susceptibility to
infection and produced similar numbers of eggs as their wild-type
littermates. The IL-10T mice displayed a significant increase in
hepatic granuloma size at the acute stage of infection, which was
associated with increased IFN-
, IL-2, IL-1ß, and TNF-
mRNA
expression in liver and elevated Th1-type cytokine production by
lymphoid cells. Despite developing an enhanced Th1-type cytokine
response, the IL-10T mice showed no consistent decrease in their
Th2-type cytokine profile. Surprisingly, although granulomatous
inflammation was enhanced at the acute stage of infection, the livers
of IL-10T mice displayed no significant increase in fibrosis and
underwent normal immune down-modulation at the chronic stage of
infection. Moreover, the down-modulated state could be induced in
IL-10T mice by sensitizing the animals to schistosome eggs before
infection, further demonstrating that the major down-regulatory
mechanism is not dependent upon IL-10. We conclude that while IL-10
plays an important role in controlling acute granulomatous
inflammation, it plays no essential role in the process of immune
down-modulation in chronic schistosome infection.
This article has been cited by other articles:
|
|
 |
|
  A. Balic, Y. M. Harcus, M. D. Taylor, F. Brombacher, and R. M. Maizels IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance Int. Immunol., October 1, 2006; 18(10): 1421 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Hassan, Y. Zhang, C. R. Engwerda, P. M. Kaye, H. Sharp, and Q. D. Bickle The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani Am. J. Pathol., September 1, 2006; 169(3): 943 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Taylor, M. Mohrs, and E. J. Pearce Regulatory T Cell Responses Develop in Parallel to Th Responses and Control the Magnitude and Phenotype of the Th Effector Populatio J. Immunol., May 15, 2006; 176(10): 5839 - 5847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baumgart, F. Tompkins, J. Leng, and M. Hesse Naturally Occurring CD4+Foxp3+ Regulatory T Cells Are an Essential, IL-10-Independent Part of the Immunoregulatory Network in Schistosoma mansoni Egg-Induced Inflammation J. Immunol., May 1, 2006; 176(9): 5374 - 5387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yao, W. Li, M. H. Kaplan, and C.-H. Chang Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells J. Exp. Med., June 20, 2005; 201(12): 1899 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Mangan, R. E. Fallon, P. Smith, N. van Rooijen, A. N. McKenzie, and P. G. Fallon Helminth Infection Protects Mice from Anaphylaxis via IL-10-Producing B Cells J. Immunol., November 15, 2004; 173(10): 6346 - 6356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. McKee and E. J. Pearce CD25+CD4+ Cells Contribute to Th2 Polarization during Helminth Infection by Suppressing Th1 Response Development J. Immunol., July 15, 2004; 173(2): 1224 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Smith, C. M. Walsh, N. E. Mangan, R. E. Fallon, J. R. Sayers, A. N. J. McKenzie, and P. G. Fallon Schistosoma mansoni Worms Induce Anergy of T Cells via Selective Up-Regulation of Programmed Death Ligand 1 on Macrophages J. Immunol., July 15, 2004; 173(2): 1240 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Barbarin, M. Arras, P. Misson, M. Delos, B. McGarry, S. H. Phan, D. Lison, and F. Huaux Characterization of the Effect of Interleukin-10 on Silica-Induced Lung Fibrosis in Mice Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 78 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Beiting, S. K. Bliss, D. H. Schlafer, V. L. Roberts, and J. A. Appleton Interleukin-10 Limits Local and Body Cavity Inflammation during Infection with Muscle-Stage Trichinella spiralis Infect. Immun., June 1, 2004; 72(6): 3129 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hesse, C. A. Piccirillo, Y. Belkaid, J. Prufer, M. Mentink-Kane, M. Leusink, A. W. Cheever, E. M. Shevach, and T. A. Wynn The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells J. Immunol., March 1, 2004; 172(5): 3157 - 3166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Stavitsky Regulation of Granulomatous Inflammation in Experimental Models of Schistosomiasis Infect. Immun., January 1, 2004; 72(1): 1 - 12. [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bliss, A. Alcaraz, and J. A. Appleton IL-10 Prevents Liver Necrosis During Murine Infection with Trichinella spiralis J. Immunol., September 15, 2003; 171(6): 3142 - 3147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. d. S. Pyrrho, J. A. Ramos, R. M. Neto, C. S. d. Silva, H. L. Lenzi, C. M. Takiya, and C. R. Gattass Dexamethasone, a Drug for Attenuation of Schistosoma mansoni Infection Morbidity Antimicrob. Agents Chemother., November 1, 2002; 46(11): 3490 - 3498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Jones, M. R. Ackermann, U. Wille, C. A. Hunter, and P. Scott Early Enhanced Th1 Response after Leishmania amazonensis Infection of C57BL/6 Interleukin-10-Deficient Mice Does Not Lead to Resolution of Infection Infect. Immun., April 1, 2002; 70(4): 2151 - 2158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Lundy and D. L. Boros Fas Ligand-Expressing B-1a Lymphocytes Mediate CD4+-T-Cell Apoptosis during Schistosomal Infection: Induction by Interleukin 4 (IL-4) and IL-10 Infect. Immun., February 1, 2002; 70(2): 812 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Vaillant, M. G. Chiaramonte, A. W. Cheever, P. D. Soloway, and T. A. Wynn Regulation of Hepatic Fibrosis and Extracellular Matrix Genes by the Th Response: New Insight into the Role of Tissue Inhibitors of Matrix Metalloproteinases J. Immunol., December 15, 2001; 167(12): 7017 - 7026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Pedras-Vasconcelos, L. R. Brunet, and E. J. Pearce Profound effect of the absence of IL-4 on T cell responses during infection with Schistosoma mansoni J. Leukoc. Biol., November 1, 2001; 70(5): 737 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. I. Restrepo, J. I. Alvarez, J. A. Castano, L. F. Arias, M. Restrepo, J. Trujillo, C. H. Colegial, and J. M. Teale Brain Granulomas in Neurocysticercosis Patients Are Associated with a Th1 and Th2 Profile Infect. Immun., July 1, 2001; 69(7): 4554 - 4560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Martin, K. Caspersen, and J. S. Dumler Immunopathology and Ehrlichial Propagation Are Regulated by Interferon-{{gamma}} and Interleukin-10 in a Murine Model of Human Granulocytic Ehrlichiosis Am. J. Pathol., May 1, 2001; 158(5): 1881 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. P. Ross, A. C. Sleigh, Y. Li, G. M. Davis, G. M. Williams, Z. Jiang, Z. Feng, and D. P. McManus Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century Clin. Microbiol. Rev., April 1, 2001; 14(2): 270 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ramaswamy, P. Kumar, and Y.-X. He A Role for Parasite-Induced PGE2 in IL-10-Mediated Host Immunoregulation by Skin Stage Schistosomula of Schistosoma mansoni J. Immunol., October 15, 2000; 165(8): 4567 - 4574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Holscher, M. Mohrs, W. J. Dai, G. Kohler, B. Ryffel, G. A. Schaub, H. Mossmann, and F. Brombacher Tumor Necrosis Factor Alpha-Mediated Toxic Shock in Trypanosoma cruzi-Infected Interleukin 10-Deficient Mice Infect. Immun., July 1, 2000; 68(7): 4075 - 4083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Hoffmann, A. W. Cheever, and T. A. Wynn IL-10 and the Dangers of Immune Polarization: Excessive Type 1 and Type 2 Cytokine Responses Induce Distinct Forms of Lethal Immunopathology in Murine Schistosomiasis J. Immunol., June 15, 2000; 164(12): 6406 - 6416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Mola, I. O. Farah, T. M. Kariuki, M. Nyindo, R. E. Blanton, and C. L. King Cytokine Control of the Granulomatous Response in Schistosoma mansoni-Infected Baboons: Role of Exposure and Treatment Infect. Immun., December 1, 1999; 67(12): 6565 - 6571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Hoffmann, S. L. James, A. W. Cheever, and T. A. Wynn Studies with Double Cytokine-Deficient Mice Reveal That Highly Polarized Th1- and Th2-Type Cytokine and Antibody Responses Contribute Equally to Vaccine-Induced Immunity to Schistosoma mansoni J. Immunol., July 15, 1999; 163(2): 927 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Fallon and D. W. Dunne Tolerization of Mice to Schistosoma mansoni Egg Antigens Causes Elevated Type 1 and Diminished Type 2 Cytokine Responses and Increased Mortality in Acute Infection J. Immunol., April 1, 1999; 162(7): 4122 - 4132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Montesano, D. G. Colley, M. T. Willard, G. L. Freeman Jr., and W. E. Secor Idiotypes Expressed Early in Experimental Schistosoma mansoni Infections Predict Clinical Outcomes of Chronic Disease J. Exp. Med., May 6, 2002; 195(9): 1223 - 1228. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
