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*
Department of Medicine, Division of Immunology and Rheumatology, Stanford University Medical Center, Stanford, CA 94305; and
Division of Basic Immunology, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
CD8ß expression results in enhanced IL-2 production and/or
altered specificity in allogeneic MHC class I-restricted T cell
hybridomas. Expression of chimeric CD8ß-
molecules (extracellular
CD8ß, transmembrane and cytoplasmic CD8) also results in
enhancement of T hybridoma responses to alloantigen, suggesting that at
least part of CD8ß’s ability to influence responses similar to those
of mature CD8+ T cells is mediated by its
extracellular domain. Current data suggest that CD8ß-mediated
response enhancement proceeds through mechanisms similar to those
mediated by CD8, i.e., interacting with MHC class I and stabilizing
CD8-associated Lck activity. In this study we present evidence that the
extracellular portion of CD8ß is capable of independent interaction
with MHC class I/ß2m dimers in the absence of CD8. In
addition, CD8ß may enhance interaction with MHC class
I/ß2m when associated with CD8. We also present
evidence from T hybridoma responses suggesting that the extracellular
portion of CD8ß is uniquely capable of efficient interaction with the
TCR/CD3 complex and may couple the TCR/CD3 complex to other surface
components capable of enhancing TCR-mediated signals. This represents
the first evidence that a critical coreceptor function can be
preferentially associated with the CD8ß subunit.
This article has been cited by other articles:
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  H.-C. Chang, K. Tan, and Y.-M. Hsu CD8{alpha}beta Has Two Distinct Binding Modes of Interaction with Peptide-Major Histocompatibility Complex Class I J. Biol. Chem., September 22, 2006; 281(38): 28090 - 28096. [Abstract] [Full Text] [PDF]
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 S. Oh, L. P. Perera, D. S. Burke, T. A. Waldmann, and J. A. Berzofsky IL-15/IL-15R{alpha}-mediated avidity maturation of memory CD8+ T cells PNAS, October 19, 2004; 101(42): 15154 - 15159. [Abstract] [Full Text] [PDF]
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 J. S. Wong, X. Wang, T. Witte, L. Nie, N. Carvou, P. Kern, and H.-C. Chang Stalk Region of {beta}-Chain Enhances the Coreceptor Function of CD8 J. Immunol., July 15, 2003; 171(2): 867 - 874. [Abstract] [Full Text] [PDF]
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 A. Arcaro, C. Gregoire, T. R. Bakker, L. Baldi, M. Jordan, L. Goffin, N. Boucheron, F. Wurm, P. A. van der Merwe, B. Malissen, et al. CD8{beta} Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lck Complexes J. Exp. Med., November 19, 2001; 194(10): 1485 - 1495. [Abstract] [Full Text] [PDF]
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A. G. Cawthon, H. Lu, and M. A. Alexander-Miller Peptide Requirement for CTL Activation Reflects the Sensitivity to CD3 Engagement: Correlation with CD8{alpha}{beta} Versus CD8{alpha}{alpha} Expression J. Immunol., September 1, 2001; 167(5): 2577 - 2584. [Abstract] [Full Text] [PDF]
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L. Devine, L. J. Kieffer, V. Aitken, and P. B. Kavathas Human CD8{beta}, But Not Mouse CD8{beta}, Can Be Expressed in the Absence of CD8{alpha} as a {beta}{beta} Homodimer J. Immunol., January 15, 2000; 164(2): 833 - 838. [Abstract] [Full Text] [PDF]
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P. Kern, R. E. Hussey, R. Spoerl, E. L. Reinherz, and H.-C. Chang Expression, Purification, and Functional Analysis of Murine Ectodomain Fragments of CD8alpha alpha and CD8alpha beta Dimers J. Biol. Chem., September 17, 1999; 274(38): 27237 - 27243. [Abstract] [Full Text] [PDF]
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