| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
John P. Robarts Research Institute,
The Department of Microbiology and Immunology, and
The Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada
CD28, a T cell costimulatory receptor, provides a signal that induces both optimal proliferation and the production of IL-2 by TCR-activated T cells. We show that the stimulation of CD28 leads to the activation of p21-activated kinase and MEK kinase 1. The same pathway was also stimulated in T cells treated with the cell-permeable ceramide analogue, C2-ceramide. The combined stimulation of either CD3 and CD28 or CD3 concurrently with C2-ceramide largely enhanced the activity of p21-activated kinase and MEK kinase 1. Therefore the Rac1/CDC42-coupled pathway(s) is a candidate that transduces and facilitates cross-talk between the CD28 costimulatory signal and the TCR signal.
This article has been cited by other articles:
|
|
 |
|
  T. E. Fox, K. L. Houck, S. M. O'Neill, M. Nagarajan, T. C. Stover, P. T. Pomianowski, O. Unal, J. K. Yun, S. J. Naides, and M. Kester Ceramide Recruits and Activates Protein Kinase C {zeta} (PKC{zeta}) within Structured Membrane Microdomains J. Biol. Chem., April 27, 2007; 282(17): 12450 - 12457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Pozo, M. Vales-Gomez, N. Mavaddat, S. C. Williamson, S. E. Chisholm, and H. Reyburn CD161 (Human NKR-P1A) Signaling in NK Cells Involves the Activation of Acid Sphingomyelinase J. Immunol., February 15, 2006; 176(4): 2397 - 2406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Y. Ma, S. A. Mikolajczak, A. Danesh, K. A. Hosiawa, C. M. Cameron, A. Takaori-Kondo, T. Uchiyama, D. J. Kelvin, and A. Ochi The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells Blood, September 15, 2005; 106(6): 2002 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Liu and M.-Z. Lai Deltex Regulates T-Cell Activation by Targeted Degradation of Active MEKK1 Mol. Cell. Biol., February 15, 2005; 25(4): 1367 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ryoo, S.-H. Huh, Y. H. Lee, K. W. Yoon, S.-G. Cho, and E.-J. Choi Negative Regulation of MEKK1-induced Signaling by Glutathione S-Transferase Mu J. Biol. Chem., October 15, 2004; 279(42): 43589 - 43594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Chu, J. Wu, X. C. Liao, J. Pardo, H. Zhao, C. Li, M. K. Mendenhall, E. Pali, M. Shen, S. Yu, et al. A Novel Role for p21-Activated Protein Kinase 2 in T Cell Activation J. Immunol., June 15, 2004; 172(12): 7324 - 7334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Mikolajczak, B. Y. Ma, T. Yoshida, R. Yoshida, D. J. Kelvin, and A. Ochi The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells J. Exp. Med., April 5, 2004; 199(7): 1025 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Cook, L. Albacker, A. August, and A. J. Henderson CD28-dependent HIV-1 Transcription Is Associated with Vav, Rac, and NF-{kappa}B Activation J. Biol. Chem., September 12, 2003; 278(37): 35812 - 35818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Salazar-Fontana, V. Barr, L. E. Samelson, and B. E. Bierer CD28 Engagement Promotes Actin Polymerization Through the Activation of the Small Rho GTPase Cdc42 in Human T Cells J. Immunol., September 1, 2003; 171(5): 2225 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hanawa, Y. Ma, S. A. Mikolajczak, M. L. Charles, T. Yoshida, R. Yoshida, C. A. Strathdee, D. W. Litchfield, and A. Ochi A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28 Blood, March 15, 2002; 99(6): 2138 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Lian, A. Toker, and J. A. Badwey Phosphorylation of the Activation Loop of {{gamma}} p21-Activated Kinase ({{gamma}}-Pak) and Related Kinases (MSTs) in Normal and Stressed Neutrophils J. Immunol., May 15, 2001; 166(10): 6349 - 6357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Skapenko, P. E. Lipsky, H.-G. Kraetsch, J. R. Kalden, and H. Schulze-Koops Antigen-Independent Th2 Cell Differentiation by Stimulation of CD28: Regulation Via IL-4 Gene Expression and Mitogen-Activated Protein Kinase Activation J. Immunol., April 1, 2001; 166(7): 4283 - 4292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yashiro-Ohtani, X.-Y. Zhou, K. Toyo-oka, X.-G. Tai, C.-S. Park, T. Hamaoka, R. Abe, K. Miyake, and H. Fujiwara Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts J. Immunol., February 1, 2000; 164(3): 1251 - 1259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Li, H. Ito, I. I. Rovira, K.-S. Kim, K. Takeda, Z.-Y. Yu, V. J. Ferrans, and T. Finkel A Role for Reactive Oxygen Species in Endothelial Cell Anoikis Circ. Res., August 20, 1999; 85(4): 304 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. V. Salojin, J. Zhang, and T. L. Delovitch TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway J. Immunol., July 15, 1999; 163(2): 844 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Schafer, S. A. Wadsworth, L. Wang, and J. J. Siekierka p38{alpha} Mitogen-Activated Protein Kinase Is Activated by CD28-Mediated Signaling and Is Required for IL-4 Production by Human CD4+CD45RO+ T Cells and Th2 Effector Cells J. Immunol., June 15, 1999; 162(12): 7110 - 7119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Kempiak, T. S. Hiura, and A. E. Nel The Jun Kinase Cascade Is Responsible for Activating the CD28 Response Element of the IL-2 Promoter: Proof of Cross-Talk with the I{kappa}B Kinase Cascade J. Immunol., March 15, 1999; 162(6): 3176 - 3187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tsuchida, S. J. Knechtle, and M. M. Hamawy CD28 Ligation Induces Tyrosine Phosphorylation of Pyk2 but Not Fak in Jurkat T Cells J. Biol. Chem., March 5, 1999; 274(10): 6735 - 6740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Johnson Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity Microbiol. Mol. Biol. Rev., March 1, 1999; 63(1): 54 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Huang, J. P. Lian, D. Robinson, and J. A. Badwey Neutrophils Stimulated with a Variety of Chemoattractants Exhibit Rapid Activation of p21-Activated Kinases (Paks): Separate Signals Are Required for Activation and Inactivation of Paks Mol. Cell. Biol., December 1, 1998; 18(12): 7130 - 7138. [Abstract] [Full Text]
|
|
|
|
|
|
J. P. Lian, R. Huang, D. Robinson, and J. A. Badwey Products of Sphingolipid Catabolism Block Activation of the p21-Activated Protein Kinases in Neutrophils J. Immunol., October 15, 1998; 161(8): 4375 - 4381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Harhaj and S.-C. Sun Ikappa B Kinases Serve as a Target of CD28 Signaling J. Biol. Chem., September 25, 1998; 273(39): 25185 - 25190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. M. Goeckeler, R. A. Masaracchia, Q. Zeng, T.-L. Chew, P. Gallagher, and R. B. Wysolmerski Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2 J. Biol. Chem., June 9, 2000; 275(24): 18366 - 18374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Xiao and S.-C. Sun Negative Regulation of the Nuclear Factor kappa B-inducing Kinase by a cis-Acting Domain J. Biol. Chem., July 7, 2000; 275(28): 21081 - 21085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Rebres, J. M. Green, M. I. Reinhold, M. Ticchioni, and E. J. Brown Membrane Raft Association of CD47 Is Necessary for Actin Polymerization and Protein Kinase C theta Translocation in Its Synergistic Activation of T Cells J. Biol. Chem., March 2, 2001; 276(10): 7672 - 7680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Fischer, A. Palmetshofer, S. Gambaryan, E. Butt, C. Jassoy, U. Walter, S. Sopper, and S. M. Lohmann Activation of cGMP-dependent Protein Kinase Ibeta Inhibits Interleukin 2 Release and Proliferation of T Cell Receptor-stimulated Human Peripheral T Cells J. Biol. Chem., February 16, 2001; 276(8): 5967 - 5974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Su, J. Cheng, J. Yang, and Z. Guo MEKK2 Is Required for T-cell Receptor Signals in JNK Activation and Interleukin-2 Gene Expression J. Biol. Chem., April 27, 2001; 276(18): 14784 - 14790. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
