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CUTTING EDGE |
*
Institut National de la Santé et de la Recherche Médicale U454, Montpellier, France;
Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique 5535, Montpellier, France;
Institut de Biologie, 34060 Montpellier, France; and
§
Institute for Virus Research, Kyoto University, Kyoto, Japan
Here we report that IL-4 specifically enhances cell surface expression of CXCR4 on resting peripheral and cord blood T cells. Whereas polarized Th2 clones express variable levels of CXCR4, expression of this receptor is undetectable on polarized Th1 clones but can be induced on the latter cells as well, following short-term culture in the presence of IL-4. The IL-4-induced CXCR4 is functional since interaction with its ligand, stromal-derived factor (SDF)-1, activates the p42 MAP-kinase ERK-2. In addition, although CXCR4 expression is down-regulated following stimulation of T cells and T cell clones via CD28 or CD3 and CD2 cell surface molecules, respectively, it is re-induced by IL-4. These data indicate an important role for IL-4 in rendering CD4+ T cells susceptible to infection with HIV via CXCR4, as well as in promoting SDF-1-induced migration of these cells.
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E. Vicenzi, P. P. Bordignon, P. Biswas, A. Brambilla, C. Bovolenta, M. Cota, F. Sinigaglia, and G. Poli Envelope-Dependent Restriction of Human Immunodeficiency Virus Type 1 Spreading in CD4+ T Lymphocytes: R5 but Not X4 Viruses Replicate in the Absence of T-Cell Receptor Restimulation J. Virol., September 1, 1999; 73(9): 7515 - 7523. [Abstract] [Full Text]
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C. Abbal, P. Jourdan, T. Hori, J. Bousquet, H. Yssel, and J. Pene TCR-mediated activation of allergen-specific CD45RO+ memory T lymphocytes results in down-regulation of cell-surface CXCR4 expression and a strongly reduced capacity to migrate in response to stromal cell-derived factor-1 Int. Immunol., September 1, 1999; 11(9): 1451 - 1462. [Abstract] [Full Text] [PDF]
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S. Iyengar, D. H. Schwartz, and J. E. K. Hildreth T Cell-Tropic HIV gp120 Mediates CD4 and CD8 Cell Chemotaxis through CXCR4 Independent of CD4: Implications for HIV Pathogenesis J. Immunol., May 15, 1999; 162(10): 6263 - 6267. [Abstract] [Full Text] [PDF]
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D. Misse, M. Cerutti, N. Noraz, P. Jourdan, J. Favero, G. Devauchelle, H. Yssel, N. Taylor, and F. Veas A CD4-Independent Interaction of Human Immunodeficiency Virus-1 gp120 With CXCR4 Induces Their Cointernalization, Cell Signaling, and T-Cell Chemotaxis Blood, April 15, 1999; 93(8): 2454 - 2462. [Abstract] [Full Text] [PDF]
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A. E. Sousa, A. F. Chaves, M. Doroana, F. Antunes, and R. M. M. Victorino Kinetics of the Changes of Lymphocyte Subsets Defined by Cytokine Production at Single Cell Level During Highly Active Antiretroviral Therapy for HIV-1 Infection J. Immunol., March 15, 1999; 162(6): 3718 - 3726. [Abstract] [Full Text] [PDF]
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P. Secchiero, D. Zella, S. Capitani, R. C. Gallo, and G. Zauli Extracellular HIV-1 Tat Protein Up-Regulates the Expression of Surface CXC-Chemokine Receptor 4 in Resting CD4+ T Cells J. Immunol., February 15, 1999; 162(4): 2427 - 2431. [Abstract] [Full Text] [PDF]
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Y. Suzuki, Y. Koyanagi, Y. Tanaka, T. Murakami, N. Misawa, N. Maeda, T. Kimura, H. Shida, J. A. Hoxie, W. A. O'Brien, et al. Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions J. Virol., January 1, 1999; 73(1): 316 - 324. [Abstract] [Full Text] [PDF]
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D. D'Ambrosio, A. Iellem, R. Bonecchi, D. Mazzeo, S. Sozzani, A. Mantovani, and F. Sinigaglia Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells J. Immunol., November 15, 1998; 161(10): 5111 - 5115. [Abstract] [Full Text] [PDF]
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P. Biswas, M. Mengozzi, B. Mantelli, F. Delfanti, A. Brambilla, E. Vicenzi, and G. Poli 1,25-Dihydroxyvitamin D3 Upregulates Functional CXCR4 Human Immunodeficiency Virus Type 1 Coreceptors in U937 Minus Clones: NF-kappa B-Independent Enhancement of Viral Replication J. Virol., October 1, 1998; 72(10): 8380 - 8383. [Abstract] [Full Text] [PDF]
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J. P. Zoeteweij, H. Golding, H. Mostowski, and A. Blauvelt Cutting Edge: Cytokines Regulate Expression and Function of the HIV Coreceptor CXCR4 on Human Mature Dendritic Cells J. Immunol., October 1, 1998; 161(7): 3219 - 3223. [Abstract] [Full Text] [PDF]
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J. Wang, E. Guan, G. Roderiquez, V. Calvert, R. Alvarez, and M. A. Norcross Role of Tyrosine Phosphorylation in Ligand-independent Sequestration of CXCR4 in Human Primary Monocytes-Macrophages J. Biol. Chem., December 21, 2001; 276(52): 49236 - 49243. [Abstract] [Full Text] [PDF]
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