| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
*
Laboratory of Experimental Immunology, Division of Basic Sciences, and
Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Reseach and Development Center, Frederick, MD 21702;
Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Washington, DC; and
§
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
Ly-49D is an activating receptor on NK
cells that does not become tyrosine phosphorylated upon
activation. This report demonstrates that immunoprecipitation of
Ly-49D, following pervanadate treatment or specific Ab cross-linking,
coprecipitates a 16-kDa tyrosine-phosphorylated protein
(pp16). Immunoblotting experiments and data from TCR-
/Fc
RI
double knockout mice confirm that pp16 is not TCR-, TCR-
, or
FcRI. Association of pp16 with Ly-49D involves a transmembrane
arginine since mutation to leucine (Ly-49DR54L)
abolishes association with pp16 in transfected P815 cells. In addition,
Ly-49DR54L transfectants fail to mediate Ca2+
mobilization following Ab cross-linking. Therefore, signaling through
Ly-49D on NK cells depends on association with a distinct tyrosine
phosphoprotein (pp16) in a manner analogous to that of TCR and FcR.
Expression of this novel signaling peptide in both the NK and myeloid
lineages indicates that pp16 is likely involved in the signal
transduction cascade of additional receptor families.
This article has been cited by other articles:
|
|
 |
|
  A. S. Tessarz, S. Weiler, K. Zanzinger, P. Angelisova, V. Horejsi, and A. Cerwenka Non-T Cell Activation Linker (NTAL) Negatively Regulates TREM-1/DAP12-Induced Inflammatory Cytokine Production in Myeloid Cells J. Immunol., February 15, 2007; 178(4): 1991 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Mason, J. Willette-Brown, L. S. Taylor, and D. W. McVicar Regulation of Ly49D/DAP12 Signal Transduction by Src-Family Kinases and CD45. J. Immunol., June 1, 2006; 176(11): 6615 - 6623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Ortaldo, R. Winkler-Pickett, J. Wigginton, M. Horner, E. W. Bere, A. T. Mason, N. Bhat, J. Cherry, M. Sanford, D. L. Hodge, et al. Regulation of ITAM-positive receptors: role of IL-12 and IL-18 Blood, February 15, 2006; 107(4): 1468 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hart, L. Flaishon, S. Becker-Herman, and I. Shachar Ly49D Receptor Expressed on Immature B Cells Regulates Their IFN-{gamma} Secretion, Actin Polymerization, and Homing J. Immunol., November 1, 2003; 171(9): 4630 - 4638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Mason, J. Willette-Brown, S. K. Anderson, W. G. Alvord, R. L. Klabansky, H. A. Young, and J. R. Ortaldo Receptor Glycosylation Regulates Ly-49 Binding to MHC Class I J. Immunol., October 15, 2003; 171(8): 4235 - 4242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Bream, R. E. Curiel, C.-R. Yu, C. E. Egwuagu, M. J. Grusby, T. M. Aune, and H. A. Young IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-{gamma} expression in murine NK cells Blood, July 1, 2003; 102(1): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao, H. Ohdan, J. O. Manilay, and M. Sykes NK Cell Tolerance in Mixed Allogeneic Chimeras J. Immunol., June 1, 2003; 170(11): 5398 - 5405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ortaldo and H. A. Young Expression of IFN-{gamma} Upon Triggering of Activating Ly49D NK Receptors In Vitro and In Vivo: Costimulation with IL-12 or IL-18 Overrides Inhibitory Receptors J. Immunol., February 15, 2003; 170(4): 1763 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. McVicar, R. Winkler-Pickett, L. S. Taylor, A. Makrigiannis, M. Bennett, S. K. Anderson, and J. R. Ortaldo Aberrant DAP12 Signaling in the 129 Strain of Mice: Implications for the Analysis of Gene-Targeted Mice J. Immunol., August 15, 2002; 169(4): 1721 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ortaldo, E. W. Bere, D. Hodge, and H. A. Young Activating Ly-49 NK Receptors: Central Role in Cytokine and Chemokine Production J. Immunol., April 15, 2001; 166(8): 4994 - 4999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Makrigiannis, A. T. Pau, A. Saleh, R. Winkler-Pickett, J. R. Ortaldo, and S. K. Anderson Class I MHC-Binding Characteristics of the 129/J Ly49 Repertoire J. Immunol., April 15, 2001; 166(8): 5034 - 5043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Ortaldo, R. Winkler-Pickett, and G. Wiegand Activating Ly-49D NK receptors: expression and function in relation to ontogeny and Ly-49 inhibitor receptors J. Leukoc. Biol., November 1, 2000; 68(5): 748 - 756. [Abstract] [Full Text]
|
|
|
|
|
|
A. P. Makrigiannis, J. Etzler, R. Winkler-Pickett, A. Mason, J. R. Ortaldo, and S. K. Anderson Identification of the Ly49L protein: evidence for activating counterparts to inhibitory Ly49 proteins J. Leukoc. Biol., November 1, 2000; 68(5): 765 - 771. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Wu, H. Cherwinski, T. Spies, J. H. Phillips, and L. L. Lanier DAP10 and DAP12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells J. Exp. Med., October 2, 2000; 192(7): 1059 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Mason Recognition of CHO cells by inhibitory and activating Ly-49 receptors J. Leukoc. Biol., October 1, 2000; 68(4): 583 - 586. [Abstract] [Full Text]
|
|
|
|
|
|
N. Aoki, S. Kimura, Y. Takiyama, Y. Atsuta, A. Abe, K. Sato, and M. Katagiri The Role of the DAP12 Signal in Mouse Myeloid Differentiation J. Immunol., October 1, 2000; 165(7): 3790 - 3796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Mason, J. Willette-Brown, A. T. Mason, D. McVicar, and J. R. Ortaldo Interaction of Ly-49D+ NK Cells with H-2Dd Target Cells Leads to Dap-12 Phosphorylation and IFN-{gamma} Secretion J. Immunol., January 15, 2000; 164(2): 603 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sconocchia, J. A. Titus, A. Mazzoni, A. Visintin, F. Pericle, S. W. Hicks, F. Malavasi, and D. M. Segal CD38 Triggers Cytotoxic Responses in Activated Human Natural Killer Cells Blood, December 1, 1999; 94(11): 3864 - 3871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ortaldo, R. Winkler-Pickett, J. Willette-Brown, R. L. Wange, S. K. Anderson, G. J. Palumbo, L. H. Mason, and D. W. McVicar Structure/Function Relationship of Activating Ly-49D and Inhibitory Ly-49G2 NK Receptors ,2 J. Immunol., November 15, 1999; 163(10): 5269 - 5277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chang, J. Dietrich, A. G. Harpur, J. A. Lindquist, A. Haude, Y. W. Loke, A. King, M. Colonna, J. Trowsdale, and M. J. Wilson Cutting Edge: KAP10, a Novel Transmembrane Adapter Protein Genetically Linked to DAP12 but with Unique Signaling Properties J. Immunol., November 1, 1999; 163(9): 4651 - 4654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Nakamura, C. Naper, E. C. Niemi, S. C. Spusta, B. Rolstad, G. W. Butcher, W. E. Seaman, and J. C. Ryan Natural Killing of Xenogeneic Cells Mediated by the Mouse Ly-49D Receptor J. Immunol., November 1, 1999; 163(9): 4694 - 4700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Makrigiannis, P. Gosselin, L. H. Mason, L. S. Taylor, D. W. McVicar, J. R. Ortaldo, and S. K. Anderson Cloning and Characterization of a Novel Activating Ly49 Closely Related to Ly49A ,2 ,3 J. Immunol., November 1, 1999; 163(9): 4931 - 4938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Williams, J. Klem, I. J. Puzanov, P. V. Sivakumar, M. Bennett, and V. Kumar Differentiation of NK1.1+, Ly49+ NK Cells from flt3+ Multipotent Marrow Progenitor Cells J. Immunol., September 1, 1999; 163(5): 2648 - 2656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Taylor and D. W. McVicar Functional Association of Fcvarepsilon RIgamma With Arginine632 of Paired Immunoglobulin-Like Receptor (PIR)-A3 in Murine Macrophages Blood, September 1, 1999; 94(5): 1790 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. H. Bakker, E. Baker, G. R. Sutherland, J. H. Phillips, and L. L. Lanier Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells PNAS, August 17, 1999; 96(17): 9792 - 9796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. George, J. R. Ortaldo, S. Lemieux, V. Kumar, and M. Bennett Tolerance and Alloreactivity of the Ly49D Subset of Murine NK Cells J. Immunol., August 15, 1999; 163(4): 1859 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Idris, H. R. C. Smith, L. H. Mason, J. R. Ortaldo, A. A. Scalzo, and W. M. Yokoyama The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing PNAS, May 25, 1999; 96(11): 6330 - 6335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. P. Kung, R.-C. Su, J. Shannon, and R. G. Miller The NKR-P1B Gene Product Is an Inhibitory Receptor on SJL/J NK Cells J. Immunol., May 15, 1999; 162(10): 5876 - 5887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Bernard, A. Cambiaggi, S. Guia, F. Bertucci, S. Granjeaud, R. Tagett, C. N'Guyen, B. R. Jordan, and E. Vivier Engagement of Natural Cytotoxicity Programs Regulates AP-1 Expression in the NKL Human NK Cell Line J. Immunol., April 1, 1999; 162(7): 4062 - 4068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. George, L. H. Mason, J. R. Ortaldo, V. Kumar, and M. Bennett Positive Recognition of MHC Class I Molecules by the Ly49D Receptor of Murine NK Cells J. Immunol., February 15, 1999; 162(4): 2035 - 2043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kubagawa, C.-C. Chen, Le Hong Ho, T. Shimada, L. Gartland, C. Mashburn, T. Uehara, J. V. Ravetch, and M. D. Cooper Biochemical Nature and Cellular Distribution of the Paired Immunoglobulin-like Receptors, PIR-A and PIR-B J. Exp. Med., January 18, 1999; 189(2): 309 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Idris, K. Iizuka, H. R.C. Smith, A. A. Scalzo, and W. M. Yokoyama Genetic Control Of Natural Killing and In Vivo Tumor Elimination by the Chok Locus J. Exp. Med., December 21, 1998; 188(12): 2243 - 2256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tomasello, L. Olcese, F. Vely, C. Geourgeon, M. Blery, A. Moqrich, D. Gautheret, M. Djabali, M.-G. Mattei, and E. Vivier Gene Structure, Expression Pattern, and Biological Activity of Mouse Killer Cell Activating Receptor-associated Protein (KARAP)/DAP-12 J. Biol. Chem., December 18, 1998; 273(51): 34115 - 34119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. McVicar, L. S. Taylor, P. Gosselin, J. Willette-Brown, A. I. Mikhael, R. L. Geahlen, M. C. Nakamura, P. Linnemeyer, W. E. Seaman, S. K. Anderson, et al. DAP12-mediated Signal Transduction in Natural Killer Cells. A DOMINANT ROLE FOR THE Syk PROTEIN-TYROSINE KINASE J. Biol. Chem., December 4, 1998; 273(49): 32934 - 32942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Smith, J. Wu, A. B. H. Bakker, J. H. Phillips, and L. L. Lanier Cutting Edge: Ly-49D and Ly-49H Associate with Mouse DAP12 and Form Activating Receptors J. Immunol., July 1, 1998; 161(1): 7 - 10. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
