The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huang, F.-P.
Right arrow Articles by Liew, F. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huang, F.-P.
Right arrow Articles by Liew, F. Y.
The Journal of Immunology, 1998, 160: 4143-4147.
Copyright © 1998 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Mice Defective in Fas Are Highly Susceptible to Leishmania major Infection Despite Elevated IL-12 Synthesis, Strong Th1 Responses, and Enhanced Nitric Oxide Production1

Fang-Ping Huang2, Damo Xu, Ehsan-O Esfandiari, William Sands3, Xiao-qing Wei and Foo Y. Liew4

Department of Immunology, University of Glasgow, Western Infirmary, Glasgow, G11 6NT United Kingdom.

MRL/MP-lpr/lpr (MRL/lpr) mice have a single mutation (lpr) of the fasapoptosis gene. The mutant mice developed significantly smaller lesions than the wild-type mice at the earlier stage of infection with the intracellular protozoan parasite Leishmania major. However, while all the wild-type mice achieved complete lesion resolution, the disease in the mutant mice progressed inexorably. The mutant mice had more IL-12 and nitrite/nitrate in the serum than wild-type mice following infection. Lymphoid cells from infected MRL/lpr mice produced more IFN-{gamma} but less IL-4 and IL-5 than cells from MRL-+/+ mice. Peritoneal macrophages from the mutant mice also produced more IL-12 and NO after stimulation with LPS. Thus, Fas expression is essential for resistance against leishmaniasis, and Fas-mediated apoptosis may form an integral part of the Th1-mediated microbicidal function.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
R. Chakour, C. Allenbach, F. Desgranges, M. Charmoy, J. Mauel, I. Garcia, P. Launois, J. Louis, and F. Tacchini-Cottier
A new function of the Fas-FasL pathway in macrophage activation
J. Leukoc. Biol., July 1, 2009; 86(1): 81 - 90.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Mise-Omata, E. Kuroda, T. Sugiura, U. Yamashita, Y. Obata, and T. S. Doi
The NF-{kappa}B RelA Subunit Confers Resistance to Leishmania major by Inducing Nitric Oxide Synthase 2 and Fas Expression but Not Th1 Differentiation
J. Immunol., April 15, 2009; 182(8): 4910 - 4916.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Eidsmo, C. Fluur, B. Rethi, S. Eriksson Ygberg, N. Ruffin, A. De Milito, H. Akuffo, and F. Chiodi
FasL and TRAIL Induce Epidermal Apoptosis and Skin Ulceration Upon Exposure to Leishmania major
Am. J. Pathol., January 1, 2007; 170(1): 227 - 239.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
M. T. M. Roberts
Current understandings on the immunology of leishmaniasis and recent developments in prevention and treatment
Br. Med. Bull., July 17, 2006; 75-76(1): 115 - 130.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Eidsmo, S. Nylen, A. Khamesipour, M.-A. Hedblad, F. Chiodi, and H. Akuffo
The Contribution of the Fas/FasL Apoptotic Pathway in Ulcer Formation during Leishmania major-Induced Cutaneous Leishmaniasis
Am. J. Pathol., April 1, 2005; 166(4): 1099 - 1108.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. L. Ribeiro-Gomes, A. C. Otero, N. A. Gomes, M. C. A. Moniz-de-Souza, L. Cysne-Finkelstein, A. C. Arnholdt, V. L. Calich, S. G. Coutinho, M. F. Lopes, and G. A. DosReis
Macrophage Interactions with Neutrophils Regulate Leishmania major Infection
J. Immunol., April 1, 2004; 172(7): 4454 - 4462.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. C. Gavrilescu and E. Y. Denkers
Apoptosis and the Balance of Homeostatic and Pathologic Responses to Protozoan Infection
Infect. Immun., November 1, 2003; 71(11): 6109 - 6115.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Chakour, R. Guler, M. Bugnon, C. Allenbach, I. Garcia, J. Mauel, J. Louis, and F. Tacchini-Cottier
Both the Fas Ligand and Inducible Nitric Oxide Synthase Are Needed for Control of Parasite Replication within Lesions in Mice Infected with Leishmania major whereas the Contribution of Tumor Necrosis Factor Is Minimal
Infect. Immun., September 1, 2003; 71(9): 5287 - 5295.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Fukui, R. Imamura, M. Umemura, T. Kawabe, and T. Suda
Pathogen-Associated Molecular Patterns Sensitize Macrophages to Fas Ligand-Induced Apoptosis and IL-1{beta} Release
J. Immunol., August 15, 2003; 171(4): 1868 - 1874.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Colmenares, P. E. Kima, E. Samoff, L. Soong, and D. McMahon-Pratt
Perforin and Gamma Interferon Are Critical CD8+ T-Cell-Mediated Responses in Vaccine-Induced Immunity against Leishmania amazonensis Infection
Infect. Immun., June 1, 2003; 71(6): 3172 - 3182.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. C. Gavrilescu and E. Y. Denkers
Interleukin-12 p40- and Fas Ligand-Dependent Apoptotic Pathways Involving STAT-1 Phosphorylation Are Triggered during Infection with a Virulent Strain of Toxoplasma gondii
Infect. Immun., May 1, 2003; 71(5): 2577 - 2583.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Muraille, C. De Trez, B. Pajak, F. A. Torrentera, P. De Baetselier, O. Leo, and Y. Carlier
Amastigote Load and Cell Surface Phenotype of Infected Cells from Lesions and Lymph Nodes of Susceptible and Resistant Mice Infected with Leishmania major
Infect. Immun., May 1, 2003; 71(5): 2704 - 2715.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Muraille, C. De Trez, M. Brait, P. De Baetselier, O. Leo, and Y. Carlier
Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 Response
J. Immunol., April 15, 2003; 170(8): 4237 - 4241.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. Aguilar Torrentera, J. D. Laman, M. Van Meurs, L. Adorini, E. Muraille, and Y. Carlier
Endogenous Interleukin-12 Is Critical for Controlling the Late but Not the Early Stage of Leishmania mexicana Infection in C57BL/6 Mice
Infect. Immun., September 1, 2002; 70(9): 5075 - 5080.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Campos-Neto, J. R. Webb, K. Greeson, R. N. Coler, Y. A. W. Skeiky, and S. G. Reed
Vaccination with Plasmid DNA Encoding TSA/LmSTI1 Leishmanial Fusion Proteins Confers Protection against Leishmania major Infection in Susceptible BALB/c Mice
Infect. Immun., June 1, 2002; 70(6): 2828 - 2836.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. J. Mueller, R. A. Wilkinson, and J. A. Fishman
Listeria monocytogenes Infection in Caspase-11-Deficient Mice
Infect. Immun., May 1, 2002; 70(5): 2657 - 2664.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. R. M. van den Brink, E. Moore, K. J. Horndasch, J. M. Crawford, J. Hoffman, G. F. Murphy, and S. J. Burakoff
Fas-Deficient lpr Mice Are More Susceptible to Graft-Versus-Host Disease
J. Immunol., January 1, 2000; 164(1): 469 - 480.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. T. Kanaly, M. Nashleanas, B. Hondowicz, and P. Scott
TNF Receptor p55 Is Required for Elimination of Inflammatory Cells Following Control of Intracellular Pathogens
J. Immunol., October 1, 1999; 163(7): 3883 - 3889.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. A. Martins, L. Q. Vieira, F. Q. Cunha, and J. S. Silva
Gamma Interferon Modulates CD95 (Fas) and CD95 Ligand (Fas-L) Expression and Nitric Oxide-Induced Apoptosis during the Acute Phase of Trypanosoma cruzi Infection: a Possible Role in Immune Response Control
Infect. Immun., August 1, 1999; 67(8): 3864 - 3871.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. L. Perry, K. Feilzer, S. Hughes, and H. D. Caldwell
Clearance of Chlamydia trachomatis from the Murine Genital Mucosa Does Not Require Perforin-Mediated Cytolysis or Fas-Mediated Apoptosis
Infect. Immun., March 1, 1999; 67(3): 1379 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H. W. Murray and C. F. Nathan
Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani
J. Exp. Med., February 15, 1999; 189(4): 741 - 746.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Ueda and G. Chaudhuri
Differential Expression of B1-containing Transcripts in Leishmania-exposed Macrophages
J. Biol. Chem., June 16, 2000; 275(25): 19428 - 19432.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.