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B Cells Are Unable to Complete All Developmental Programs1
Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35394
The generation of VH81X heavy chain 
-light chain-expressing B
cells (VH81X-+ B cells) was studied in VH81X heavy
chain transgenic mice as well as in VH81X JH -/- and VH81X JH -/-
Ck -/- mice, in which competition resulting from expression of heavy
and light chains from the endogenous heavy and 
light chain loci was
prevented. We show that although light chain gene rearrangements
occur normally and give rise to light chains that associate with the
transgenic heavy chain to form surface and soluble IgM molecules,
further B cell development is almost totally blocked. The few
VH81X-+ B cells that are generated progress into a
mature compartment (expressing surface CD21, CD22, CD23, and low CD24
and having a relatively long life span) but they also have reduced
levels of surface Ig receptor and express higher amounts of Fas Ag than
VH81X-+ B cells. These VH81X-+ B cells
reach the peripheral lymphoid organs and accumulate in the
periarteriolar lymphoid sheath but are unable to generate primary B
cell follicles. In other heavy chain transgenic mice (MD2, M167, and
M54), + B cells are generated. However, they seem to be
preferentially selected in the peripheral repertoire of some transgenic
heavy chain mice (M54) but not in others (MD2, M167). These studies
show that a crucial selection step is necessary for B cell survival and
maintenance in which B cells, similar to T cells, receive signals
depending on their clonal receptors.
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