| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
School of Biological Science, University of Manchester, Manchester; and
MRC (Medical Research Council) Laboratory of Molecular Biology, Cambridge, United Kingdom
Mice in which either the IL-4 or the IL-13 gene has been disrupted (IL-4 KO and IL-13 KO) were susceptible to infection with the intestinal nematode Trichuris muris, whereas their wild-type littermates were highly resistant and expelled the parasite. IL-4 KO mice showed diminished Th2-type responses with T. muris infection and also failed to produce parasite-specific IgG1 Abs. Although IL-13 KO mice made reduced Th2-type responses early in infection, they were capable of generating strong Th2-type responses at later time points and were unable to regulate the magnitude of their Ab isotype response. These results confirm the importance of IL-4 in resistance to T. muris and provide the first demonstration of an important role for IL-13 in resistance to helminth infection. The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play important yet different roles in mediating immunity to intestinal helminths.
This article has been cited by other articles:
|
|
 |
|
  M. R. Hepworth and R. K. Grencis Disruption of Th2 Immunity Results in a Gender-Specific Expansion of IL-13 Producing Accessory NK Cells during Helminth Infection J. Immunol., September 15, 2009; 183(6): 3906 - 3914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Massacand, R. C. Stettler, R. Meier, N. E. Humphreys, R. K. Grencis, B. J. Marsland, and N. L. Harris Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function PNAS, August 18, 2009; 106(33): 13968 - 13973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Perrigoue, C. Zaph, K. Guild, Y. Du, and D. Artis IL-31-IL-31R Interactions Limit the Magnitude of Th2 Cytokine-Dependent Immunity and Inflammation following Intestinal Helminth Infection J. Immunol., May 15, 2009; 182(10): 6088 - 6094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Steenwinckel, J. Louahed, M. M. Lemaire, C. Sommereyns, G. Warnier, A. McKenzie, F. Brombacher, J. Van Snick, and J.-C. Renauld IL-9 Promotes IL-13-Dependent Paneth Cell Hyperplasia and Up-Regulation of Innate Immunity Mediators in Intestinal Mucosa J. Immunol., April 15, 2009; 182(8): 4737 - 4743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Nair, K. J. Guild, Y. Du, C. Zaph, G. D. Yancopoulos, D. M. Valenzuela, A. Murphy, S. Stevens, M. Karow, and D. Artis Goblet Cell-Derived Resistin-Like Molecule {beta} Augments CD4+ T Cell Production of IFN-{gamma} and Infection-Induced Intestinal Inflammation J. Immunol., October 1, 2008; 181(7): 4709 - 4715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Cihakova, J. G. Barin, M. Afanasyeva, M. Kimura, D. Fairweather, M. Berg, M. V. Talor, G. C. Baldeviano, S. Frisancho, K. Gabrielson, et al. Interleukin-13 Protects Against Experimental Autoimmune Myocarditis by Regulating Macrophage Differentiation Am. J. Pathol., May 1, 2008; 172(5): 1195 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhao, B. Zheng, Y. Huang, D. Yang, S. Katzman, C. Chang, D. Fowell, and W.-p. Zeng Interaction between GATA-3 and the Transcriptional Coregulator Pias1 Is Important for the Regulation of Th2 Immune Responses J. Immunol., December 15, 2007; 179(12): 8297 - 8304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Muller, W. Stenzel, G. Kohler, C. Werner, T. Polte, G. Hansen, N. Schutze, R. K. Straubinger, M. Blessing, A. N. J. McKenzie, et al. IL-13 Induces Disease-Promoting Type 2 Cytokines, Alternatively Activated Macrophages and Allergic Inflammation during Pulmonary Infection of Mice with Cryptococcus neoformans J. Immunol., October 15, 2007; 179(8): 5367 - 5377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, J. Steeds, Y. Motomura, Y. Deng, M. Verma-Gandhu, R. T El-Sharkawy, J. T McLaughlin, R. K Grencis, and W. I Khan CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection Gut, July 1, 2007; 56(7): 949 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Cliffe, C. S. Potten, C. E. Booth, and R. K. Grencis An Increase in Epithelial Cell Apoptosis Is Associated with Chronic Intestinal Nematode Infection Infect. Immun., April 1, 2007; 75(4): 1556 - 1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. deSchoolmeester, H. Manku, and K. J. Else The Innate Immune Responses of Colonic Epithelial Cells to Trichuris muris Are Similar in Mouse Strains That Develop a Type 1 or Type 2 Adaptive Immune Response. Infect. Immun., November 1, 2006; 74(11): 6280 - 6286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zaph, K. A. Rook, M. Goldschmidt, M. Mohrs, P. Scott, and D. Artis Persistence and Function of Central and Effector Memory CD4+ T Cells following Infection with a Gastrointestinal Helminth J. Immunol., July 1, 2006; 177(1): 511 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Owyang, C. Zaph, E. H. Wilson, K. J. Guild, T. McClanahan, H. R. P. Miller, D. J. Cua, M. Goldschmidt, C. A. Hunter, R. A. Kastelein, et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract J. Exp. Med., April 17, 2006; 203(4): 843 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Little, L. V. Bell, L. J. Cliffe, and K. J. Else The Characterization of Intraepithelial Lymphocytes, Lamina Propria Leukocytes, and Isolated Lymphoid Follicles in the Large Intestine of Mice Infected with the Intestinal Nematode Parasite Trichuris muris J. Immunol., November 15, 2005; 175(10): 6713 - 6722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Datta, M. L. deSchoolmeester, C. Hedeler, N. W. Paton, A. M. Brass, and K. J. Else Identification of Novel Genes in Intestinal Tissue That Are Regulated after Infection with an Intestinal Nematode Parasite Infect. Immun., July 1, 2005; 73(7): 4025 - 4033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Cliffe, N. E Humphreys, T. E. Lane, C. S. Potten, C. Booth, and R. K. Grencis Accelerated Intestinal Epithelial Cell Turnover: A New Mechanism of Parasite Expulsion Science, June 3, 2005; 308(5727): 1463 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Wang, M. E. Shin, P. A. Knight, D. Artis, D. G. Silberg, E. Suh, and G. D. Wu Regulation of RELM/FIZZ isoform expression by Cdx2 in response to innate and adaptive immune stimulation in the intestine Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G1074 - G1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pernthaner, S.-A. Cole, L. Morrison, and W. R. Hein Increased Expression of Interleukin-5 (IL-5), IL-13, and Tumor Necrosis Factor Alpha Genes in Intestinal Lymph Cells of Sheep Selected for Enhanced Resistance to Nematodes during Infection with Trichostrongylus colubriformis Infect. Immun., April 1, 2005; 73(4): 2175 - 2183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Artis, A. Villarino, M. Silverman, W. He, E. M. Thornton, S. Mu, S. Summer, T. M. Covey, E. Huang, H. Yoshida, et al. The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity J. Immunol., November 1, 2004; 173(9): 5626 - 5634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Kitching, A. L. Turner, G. R.A. Wilson, K. L. Edgtton, P. G. Tipping, and S. R. Holdsworth Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-Mediated Crescentic Glomerulonephritis J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2373 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Bancroft, N. E. Humphreys, J. J. Worthington, H. Yoshida, and R. K. Grencis WSX-1: A Key Role in Induction of Chronic Intestinal Nematode Infection J. Immunol., June 15, 2004; 172(12): 7635 - 7641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Negrao-Correa, D. G. Souza, V. Pinho, M. M. Barsante, A. L. S. Souza, and M. M. Teixeira Platelet-Activating Factor Receptor Deficiency Delays Elimination of Adult Worms but Reduces Fecundity in Strongyloides venezuelensis-Infected Mice Infect. Immun., February 1, 2004; 72(2): 1135 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Spencer, L. Shultz, and T. V. Rajan T Cells Are Required for Host Protection against Brugia malayi but Need Not Produce or Respond to Interleukin-4 Infect. Immun., June 1, 2003; 71(6): 3097 - 3106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. deSchoolmeester, M. C. Little, B. J. Rollins, and K. J. Else Absence of CC Chemokine Ligand 2 Results in an Altered Th1/Th2 Cytokine Balance and Failure to Expel Trichuris muris Infection J. Immunol., May 1, 2003; 170(9): 4693 - 4700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Chiaramonte, M. Mentink-Kane, B. A. Jacobson, A. W. Cheever, M. J. Whitters, M. E.P. Goad, A. Wong, M. Collins, D. D. Donaldson, M. J. Grusby, et al. Regulation and Function of the Interleukin 13 Receptor {alpha} 2 During a T Helper Cell Type 2-dominant Immune Response J. Exp. Med., March 17, 2003; 197(6): 687 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Johnson, R. A. Parker, J. E. Johnson, and B. S. Graham IL-13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced Eosinophilia After Respiratory Syncytial Virus Challenge J. Immunol., February 15, 2003; 170(4): 2037 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Dearman, C. J. Betts, N. Humphreys, B. F. Flanagan, N. J. Gilmour, D. A. Basketter, and I. Kimber Chemical Allergy: Considerations for the Practical Application of Cytokine Profiling Toxicol. Sci., February 1, 2003; 71(2): 137 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Whittaker, N. Niu, U.-A. Temann, A. Stoddard, R. A. Flavell, A. Ray, R. J. Homer, and L. Cohn Interleukin-13 Mediates a Fundamental Pathway for Airway Epithelial Mucus Induced by CD4 T Cells and Interleukin-9 Am. J. Respir. Cell Mol. Biol., November 1, 2002; 27(5): 593 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Artis, S. Shapira, N. Mason, K. M. Speirs, M. Goldschmidt, J. Caamano, H.-C. Liou, C. A. Hunter, and P. Scott Differential Requirement for NF-{kappa}B Family Members in Control of Helminth Infection and Intestinal Inflammation J. Immunol., October 15, 2002; 169(8): 4481 - 4487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Humphreys and R. K. Grencis Effects of Ageing on the Immunoregulation of Parasitic Infection Infect. Immun., September 1, 2002; 70(9): 5148 - 5157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Hurst, T. Muchamuel, D. M. Gorman, J. M. Gilbert, T. Clifford, S. Kwan, S. Menon, B. Seymour, C. Jackson, T. T. Kung, et al. New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25 J. Immunol., July 1, 2002; 169(1): 443 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Schopf, K. F. Hoffmann, A. W. Cheever, J. F. Urban Jr., and T. A. Wynn IL-10 Is Critical for Host Resistance and Survival During Gastrointestinal Helminth Infection J. Immunol., March 1, 2002; 168(5): 2383 - 2392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Akiho, P. Blennerhassett, Y. Deng, and S. M. Collins Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells Am J Physiol Gastrointest Liver Physiol, February 1, 2002; 282(2): G226 - G232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Spencer, L. Shultz, and T. V. Rajan Interleukin-4 Receptor-Stat6 Signaling in Murine Infections with a Tissue-Dwelling Nematode Parasite Infect. Immun., December 1, 2001; 69(12): 7743 - 7752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Helmby, K. Takeda, S. Akira, and R. K. Grencis Interleukin (Il)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13 J. Exp. Med., August 6, 2001; 194(3): 355 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Blackwell and K. J. Else B Cells and Antibodies Are Required for Resistance to the Parasitic Gastrointestinal Nematode Trichuris muris Infect. Immun., June 1, 2001; 69(6): 3860 - 3868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. I. Khan, B. A. Vallance, P. A. Blennerhassett, Y. Deng, E. F. Verdu, K. I. Matthaei, and S. M. Collins Critical Role for Signal Transducer and Activator of Transcription Factor 6 in Mediating Intestinal Muscle Hypercontractility and Worm Expulsion in Trichinella spiralis-Infected Mice Infect. Immun., February 1, 2001; 69(2): 838 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Mountford, K. G. Hogg, P. S. Coulson, and F. Brombacher Signaling via Interleukin-4 Receptor {alpha} Chain Is Required for Successful Vaccination against Schistosomiasis in BALB/c Mice Infect. Immun., January 1, 2001; 69(1): 228 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Ehigiator, A. W. Stadnyk, and T. D. G. Lee Extract of Nippostrongylus brasiliensis Stimulates Polyclonal Type-2 Immunoglobulin Response by Inducing De Novo Class Switch Infect. Immun., September 1, 2000; 68(9): 4913 - 4922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Urban, H. Fang, Q. Liu, M. J. Ekkens, S.-J. Chen, D. Nguyen, V. Mitro, D. D. Donaldson, C. Byrd, R. Peach, et al. IL-13-Mediated Worm Expulsion Is B7 Independent and IFN-{gamma} Sensitive J. Immunol., April 15, 2000; 164(8): 4250 - 4256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Taylor, C. J. Betts, and K. J. Else Peripheral Cytokine Responses to Trichuris muris Reflect Those Occurring Locally at the Site of Infection Infect. Immun., April 1, 2000; 68(4): 1815 - 1819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Heinzmann, X.-Q. Mao, M. Akaiwa, R.T. Kreomer, P.-S. Gao, K. Ohshima, R. Umeshita, Y. Abe, S. Braun, T. Yamashita, et al. Genetic variants of IL-13 signalling and human asthma and atopy Hum. Mol. Genet., March 1, 2000; 9(4): 549 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Fallon, E. J. Richardson, G. J. McKenzie, and A. N. J. McKenzie Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent J. Immunol., March 1, 2000; 164(5): 2585 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Johansson, S. Ingvarsson, P. Bjorck, and C. A. K. Borrebaeck Human Interdigitating Dendritic Cells Induce Isotype Switching and IL-13-Dependent IgM Production in CD40-Activated Naive B Cells J. Immunol., February 15, 2000; 164(4): 1847 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Urban Jr., L. Schopf, S. C. Morris, T. Orekhova, K. B. Madden, C. J. Betts, H. R. Gamble, C. Byrd, D. Donaldson, K. Else, et al. Stat6 Signaling Promotes Protective Immunity Against Trichinella spiralis Through a Mast Cell- and T Cell-Dependent Mechanism J. Immunol., February 15, 2000; 164(4): 2046 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Richard, R. K. Grencis, N. E. Humphreys, J.-C. Renauld, and J. Van Snick Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice PNAS, January 18, 2000; 97(2): 767 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. P. Heinzel and R. A. Maier Jr. Interleukin-4-Independent Acceleration of Cutaneous Leishmaniasis in Susceptible BALB/c Mice following Treatment with Anti-CTLA4 Antibody Infect. Immun., December 1, 1999; 67(12): 6454 - 6460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Artis, N. E. Humphreys, A. J. Bancroft, N. J. Rothwell, C. S. Potten, and R. K. Grencis Tumor Necrosis Factor {alpha} Is a Critical Component of Interleukin 13-Mediated Protective T Helper Cell Type 2 Responses during Helminth Infection J. Exp. Med., October 4, 1999; 190(7): 953 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Johnson and B. S. Graham Secreted Respiratory Syncytial Virus G Glycoprotein Induces Interleukin-5 (IL-5), IL-13, and Eosinophilia by an IL-4-Independent Mechanism J. Virol., October 1, 1999; 73(10): 8485 - 8495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Dent, T. M. Doherty, W. E. Paul, A. Sher, and L. M. Staudt BCL-6-Deficient Mice Reveal an IL-4-Independent, STAT6-Dependent Pathway That Controls Susceptibility to Infection by Leishmania major J. Immunol., August 15, 1999; 163(4): 2098 - 2103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Poudrier, P. Graber, S. Herren, D. Gretener, G. Elson, C. Berney, J.-F. Gauchat, and M. H. Kosco-Vilbois A Soluble Form of IL-13 Receptor {alpha}1 Promotes IgG2a and IgG2b Production by Murine Germinal Center B Cells J. Immunol., August 1, 1999; 163(3): 1153 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jankovic, M. C. Kullberg, N. Noben-Trauth, P. Caspar, J. M. Ward, A. W. Cheever, W. E. Paul, and A. Sher Schistosome-Infected IL-4 Receptor Knockout (KO) Mice, in Contrast to IL-4 KO Mice, Fail to Develop Granulomatous Pathology While Maintaining the Same Lymphokine Expression Profile J. Immunol., July 1, 1999; 163(1): 337 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mohrs, B. Ledermann, G. Kohler, A. Dorfmuller, A. Gessner, and F. Brombacher Differences Between IL-4- and IL-4 Receptor {alpha}-Deficient Mice in Chronic Leishmaniasis Reveal a Protective Role for IL-13 Receptor Signaling J. Immunol., June 15, 1999; 162(12): 7302 - 7308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Noben-Trauth, W. E. Paul, and D. L. Sacks IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains J. Immunol., May 15, 1999; 162(10): 6132 - 6140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cohn, R. J. Homer, H. MacLeod, M. Mohrs, F. Brombacher, and K. Bottomly Th2-Induced Airway Mucus Production Is Dependent on IL-4R{alpha}, But Not on Eosinophils J. Immunol., May 15, 1999; 162(10): 6178 - 6183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Grünig, M. Warnock, A. E. Wakil, R. Venkayya, F. Brombacher, D. M. Rennick, D. Sheppard, M. Mohrs, D. D. Donaldson, R. M. Locksley, et al. Requirement for IL-13 Independently of IL-4 in Experimental Asthma Science, December 18, 1998; 282(5397): 2261 - 2263. [Abstract] [Full Text]
|
|
|
|
|
|
I-C. Ho, D. Lo, and L. H. Glimcher c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4-dependent and -independent Mechanisms J. Exp. Med., November 16, 1998; 188(10): 1859 - 1866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Faulkner, J.-C. Renauld, J. Van Snick, and R. K. Grencis Interleukin-9 Enhances Resistance to the Intestinal Nematode Trichuris muris Infect. Immun., August 1, 1998; 66(8): 3832 - 3840. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
