| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
*
Unité d’Oncologie Virale, Département SIDA et Rétrovirus, Institut Pasteur, Paris, and
Service des Maladies Infectieuses et Tropicales, Hôpital Militaire Bégin, Saint Mandé, France
It has been proposed that HIV infection is associated with an
imbalance in Th1 and Th2 subsets. Recent reports indicate that Th1 and
Th2 effectors differ in their susceptibility to activation-induced
apoptosis. To determine whether increased T cell apoptosis in
HIV-infected patients contributes to alterations in cytokine synthesis,
we performed single-cell analysis of type 1 and type 2 cytokine
production by CD4 and CD8 T cells, simultaneously with detection of
apoptosis. We demonstrate that a differential alteration in
representation of Th1 subsets, rather than commitment of T cells to
secrete Th2 cytokines, occurs throughout HIV infection. A significant
decrease in the number of IL-2- or TNF-
-producing T cells was
observed, whereas those producing IFN-
remained preserved.
Furthermore, there is a gradient of susceptibility to
activation-induced apoptosis (IL-2 < IFN- < TNF-) among
the different Th1 subsets. This gradient was detected in both CD4 and
CD8 subsets, as well as in control donors and HIV-infected patients, in
whom the susceptibility to apoptosis of IL-2 and IFN- producers was
increased compared with controls. This differential intrinsic apoptosis
susceptibility of Th1 effectors was found to be tightly regulated by
Bcl-2 expression. In HIV-infected persons, disappearance of
IL-2-producing T cells was a good indicator of disease progression and
was correlated with the progressive shrinkage of the
CD4+CD45RA+ T cell compartment and a
gradual increased susceptibility to activation-induced apoptosis of the
IL-2-producing subset. This close relationship between the
CD45RA/CD45R0 ratio, the level of type 1 cytokine production, and
susceptibility to apoptosis should be considered in HIV-infected
patients under antiviral or immune-based therapies.
This article has been cited by other articles:
|
|
 |
|
  E. Priceputu, I. Rodrigue, P. Chrobak, J. Poudrier, T. W. Mak, Z. Hanna, C. Hu, D. G. Kay, and P. Jolicoeur The Nef-Mediated AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Increased Fas/FasL Expression on T Cells and T-Cell Death but Is Not Prevented in Fas-, FasL-, Tumor Necrosis Factor Receptor 1-, or Interleukin-1{beta}-Converting Enzyme-Deficient or Bcl2-Expressing Transgenic Mice J. Virol., May 15, 2005; 79(10): 6377 - 6391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-L. Perfettini, T. Roumier, M. Castedo, N. Larochette, P. Boya, B. Raynal, V. Lazar, F. Ciccosanti, R. Nardacci, J. Penninger, et al. NF-{kappa}B and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope J. Exp. Med., March 1, 2004; 199(5): 629 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. I. Rutitzky, G. A. Mirkin, and M. J. Stadecker Apoptosis by Neglect of CD4+ Th Cells in Granulomas: A Novel Effector Mechanism Involved in the Control of Egg-Induced Immunopathology in Murine Schistosomiasis J. Immunol., August 15, 2003; 171(4): 1859 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Alimonti, T. B. Ball, and K. R. Fowke Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS J. Gen. Virol., July 1, 2003; 84(7): 1649 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. AKDIS, A. TRAUTMANN, S. KLUNKER, I. DAIGLE, U. C. KUCUKSEZER, W. DEGLMANN, R. DISCH, K. BLASER, and C. A. AKDIS T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells FASEB J, June 1, 2003; 17(9): 1026 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Itescu and R. John Interactions between the recipient immune system and the left ventricular assist device surface: immunological and clinical implications Ann. Thorac. Surg., June 1, 2003; 75(90060): S58 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jekle, O. T. Keppler, E. De Clercq, D. Schols, M. Weinstein, and M. A. Goldsmith In Vivo Evolution of Human Immunodeficiency Virus Type 1 toward Increased Pathogenicity through CXCR4-Mediated Killing of Uninfected CD4 T Cells J. Virol., May 15, 2003; 77(10): 5846 - 5854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Douglas, S. Durako, K. E. Sullivan, M. Camarca, A.-B. Moscicki, and C. M. Wilson TH1 and TH2 Cytokine mRNA and Protein Levels in Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Youths Clin. Vaccine Immunol., May 1, 2003; 10(3): 399 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ledru, M. Fevrier, H. Lecoeur, S. Garcia, S. Boullier, and M.-L. Gougeon A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper-2 polarization in HIV infection Blood, April 15, 2003; 101(8): 3102 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nakamoto, S. Kaneko, and K. Kobayashi Increased susceptibility to apoptosis and attenuated Bcl-2 expression in T lymphocytes and monocytes from patients with advanced chronic hepatitis C J. Leukoc. Biol., July 1, 2002; 72(1): 49 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Akari, S. Bour, S. Kao, A. Adachi, and K. Strebel The Human Immunodeficiency Virus Type 1 Accessory Protein Vpu Induces Apoptosis by Suppressing the Nuclear Factor {kappa}B-dependent Expression of Antiapoptotic Factors J. Exp. Med., November 5, 2001; 194(9): 1299 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Braun, J. M. Wang, E. Lahey, R. L. Rabin, and B. L. Kelsall Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes Blood, June 1, 2001; 97(11): 3531 - 3536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Badley, A. A. Pilon, A. Landay, and D. H. Lynch Mechanisms of HIV-associated lymphocyte apoptosis Blood, November 1, 2000; 96(9): 2951 - 2964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Somma, L. Tuosto, M. S. G. Montani, M. M. Di Somma, E. Cundari, and E. Piccolella Engagement of CD4 Before TCR Triggering Regulates Both Bax- and Fas (CD95)-Mediated J. Immunol., May 15, 2000; 164(10): 5078 - 5087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ledru, N. Christeff, O. Patey, P. de Truchis, J.-C. Melchior, and M.-L. Gougeon Alteration of tumor necrosis factor-alpha T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus-associated lipodystrophy syndrome Blood, May 15, 2000; 95(10): 3191 - 3198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fernandez-Fresnedo, M. A. Ramos, M. C. Gonzalez-Pardo, A. L. M. de Francisco, M. Lopez-Hoyos, and M. Arias B lymphopenia in uraemia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2 Nephrol. Dial. Transplant., April 1, 2000; 15(4): 502 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-X. Zhao, G. Lajoie, H. Zhang, B. Chiu, U. Payne, and R. D. Inman Tumor Necrosis Factor Receptor p55-Deficient Mice Respond to Acute Yersinia enterocolitica Infection with Less Apoptosis and More Effective Host Resistance Infect. Immun., March 1, 2000; 68(3): 1243 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cicala, J. Arthos, A. Rubbert, S. Selig, K. Wildt, O. J. Cohen, and A. S. Fauci HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4+ T cells PNAS, February 1, 2000; 97(3): 1178 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Ankersmit, N. M. Edwards, M. Schuster, R. John, A. Kocher, E. A. Rose, M. Oz, and S. Itescu Quantitative Changes In T-Cell Populations After Left Ventricular Assist Device Implantation : Relationship to T-Cell Apoptosis and Soluble CD95 Circulation, November 9, 1999; 100 (2009): II-211 - II-215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Varadhachary, M. E. Peter, S. N. Perdow, P. H. Krammer, and P. Salgame Selective Up-Regulation of Phosphatidylinositol 3'-Kinase Activity in Th2 Cells Inhibits Caspase-8 Cleavage at the Death-Inducing Complex: A Mechanism for Th2 Resistance from Fas-Mediated Apoptosis J. Immunol., November 1, 1999; 163(9): 4772 - 4779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Alcouffe, S. Caspar-Bauguil, V. Garcia, R. Salvayre, M. Thomsen, and H. Benoist Oxidized low density lipoproteins induce apoptosis in PHA-activated peripheral blood mononuclear cells and in the Jurkat T-cell line J. Lipid Res., July 1, 1999; 40(7): 1200 - 1210. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
