HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Groux, H. Articles by Roncarolo, M.-G. Search for Related Content PubMed PubMed Citation Articles by Groux, H. Articles by Roncarolo, M.-G. Pubmed/NCBI databases Substance via MeSH

Inhibitory and Stimulatory Effects of IL-10 on Human CD8⁺ T Cells¹

Immunobiology Department, DNAX Research Institute of Molecular Immunology and Cellular Biology, Palo Alto, CA 94304

IL-10 is a well-documented immunosuppressant that inhibits macrophage-dependent Ag presentation and CD4⁺ T cell proliferation in vitro. We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8⁺ T cells when added concomitantly with the Ag in the presence of APC. Moreover, the generation of allospecific cytotoxic activity is inhibited by IL-10. These effects are indirect and are mediated through inhibition of the costimulatory functions of APC. In contrast, IL-10 has no direct inhibitory effects on the proliferation of purified CD8⁺ T cells activated by anti-CD3 mAb and promotes the growth of activated CD8⁺ T cells in combination with low doses of IL-2. Taken together, these results indicate that IL-10 has differential effects on CD8⁺ T cells depending on their state of activation, which may explain both the enhancing and inhibitory effects observed after IL-10 treatment in different in vivo experimental models.