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The Journal of Immunology, 1998, 160: 3188-3193.
Copyright © 1998 by The American Association of Immunologists

Inhibitory and Stimulatory Effects of IL-10 on Human CD8+ T Cells1

Hervé Groux2, Mike Bigler, Jan E. de Vries3 and Maria-Grazia Roncarolo4

Immunobiology Department, DNAX Research Institute of Molecular Immunology and Cellular Biology, Palo Alto, CA 94304

IL-10 is a well-documented immunosuppressant that inhibits macrophage-dependent Ag presentation and CD4+ T cell proliferation in vitro. We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag in the presence of APC. Moreover, the generation of allospecific cytotoxic activity is inhibited by IL-10. These effects are indirect and are mediated through inhibition of the costimulatory functions of APC. In contrast, IL-10 has no direct inhibitory effects on the proliferation of purified CD8+ T cells activated by anti-CD3 mAb and promotes the growth of activated CD8+ T cells in combination with low doses of IL-2. Taken together, these results indicate that IL-10 has differential effects on CD8+ T cells depending on their state of activation, which may explain both the enhancing and inhibitory effects observed after IL-10 treatment in different in vivo experimental models.




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