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CD1.1 Expression by Mouse Antigen-Presenting Cells and Marginal Zone B Cells¹

Department of Molecular Biology, Princeton University, Princeton, NJ 08544

Mouse CD1.1 is an MHC class I-like, non-MHC-encoded, surface glycoprotein that can be recognized by T cells, in particular NK1.1⁺ T cells, a subset of ß T cells with semiinvariant TCRs that promptly releases potent cytokines such as IL-4 and IFN- upon stimulation. To gain insight into the function of CD1.1, a panel of nine mAbs was generated and used to biochemically characterize and monitor the surface expression of CD1.1 on different cell types. CD1.1 is a heavily glycosylated, ß₂-microglobulin-associated surface protein. Its recognition by a panel of 12 V14-positive and -negative CD1-specific ß T cell hybridomas was blocked by two groups of mAbs that bound to adjacent clusters of epitopes, indicating that different ß TCRs bind to the same region of CD1.1, presumably above the groove. Remarkably, CD1.1 was mainly expressed by dendritic cells, B cells, and macrophages, suggesting a function in Ag presentation to Th cells. Furthermore, the cell type that expressed the highest levels of CD1.1 was the splenic marginal zone B cell, a distinct subset of B cells that also expresses CD21 (the C3d receptor) and may be involved in natural responses to bacterial Ags. Altogether, the results support the idea that CD1.1 may function in recruiting a form of innate help from specialized cytokine producer ß T cells to APCs, a role that might be important at the preadaptive phase of immune responses to some microbial pathogens.

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