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CUTTING EDGE |
*
Basel Institute for Immunology, Basel, Switzerland;
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Leukocyte activation can be negatively regulated by inhibitory receptors specific for MHC class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all lymphoid and myelomonocytic cell types, other receptors display a more selective tissue distribution. Here we characterize an inhibitory receptor, termed ILT4, which is selectively expressed in monocytes, macrophages, and dendritic cells (DCs), binds classical class I molecules and the nonclassical class I molecules HLA-G, and transduces negative signals that can inhibit early signaling events triggered by stimulatory receptors. ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity.
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P. Paul, F. A. Cabestre, F.-A. Le Gal, I. Khalil-Daher, C. Le Danff, M. Schmid, S. Mercier, M.-F. Avril, J. Dausset, J.-G. Guillet, et al. Heterogeneity of HLA-G Gene Transcription and Protein Expression in Malignant Melanoma Biopsies Cancer Res., April 1, 1999; 59(8): 1954 - 1960. [Abstract] [Full Text] [PDF]
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J. M. Lu-Kuo, D. M. Joyal, K. F. Austen, and H. R. Katz gp49B1 Inhibits IgE-initiated Mast Cell Activation through Both Immunoreceptor Tyrosine-based Inhibitory Motifs, Recruitment of src Homology 2 Domain-containing Phosphatase-1, and Suppression of Early and Late Calcium Mobilization J. Biol. Chem., February 26, 1999; 274(9): 5791 - 5796. [Abstract] [Full Text] [PDF]
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C. S. Chang, L. Brossay, M. Kronenberg, and K. P. Kane The Murine Nonclassical Class I Major Histocompatibility Complex-like CD1.1 Molecule Protects Target Cells from Lymphokine-activated Killer Cell Cytolysis J. Exp. Med., February 1, 1999; 189(3): 483 - 491. [Abstract] [Full Text] [PDF]
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S. Agrawal, J. Marquet, G. J. Freeman, A. Tawab, P. L. Bouteiller, P. Roth, W. Bolton, G. Ogg, L. Boumsell, and A. Bensussan Cutting Edge: MHC Class I Triggering by a Novel Cell Surface Ligand Costimulates Proliferation of Activated Human T Cells J. Immunol., February 1, 1999; 162(3): 1223 - 1226. [Abstract] [Full Text] [PDF]
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H. Kubagawa, C.-C. Chen, Le Hong Ho, T. Shimada, L. Gartland, C. Mashburn, T. Uehara, J. V. Ravetch, and M. D. Cooper Biochemical Nature and Cellular Distribution of the Paired Immunoglobulin-like Receptors, PIR-A and PIR-B J. Exp. Med., January 18, 1999; 189(2): 309 - 318. [Abstract] [Full Text] [PDF]
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H. Nakajima, J. Samaridis, L. Angman, and M. Colonna Cutting Edge: Human Myeloid Cells Express an Activating ILT Receptor (ILT1) That Associates with Fc Receptor {gamma}-Chain J. Immunol., January 1, 1999; 162(1): 5 - 8. [Abstract] [Full Text] [PDF]
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T. Ulyanova, D. D. Shah, and M. L. Thomas Molecular Cloning of MIS, a Myeloid Inhibitory Siglec, That Binds Protein-tyrosine Phosphatases SHP-1 and SHP-2 J. Biol. Chem., April 20, 2001; 276(17): 14451 - 14458. [Abstract] [Full Text] [PDF]
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N. Lila, N. Rouas-Freiss, J. Dausset, A. Carpentier, and E. D. Carosella Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: A CD4+ T cell regulatory mechanism PNAS, October 9, 2001; 98(21): 12150 - 12155. [Abstract] [Full Text] [PDF]
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