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The Primary Site of CD4^-8^-B220⁺ ß T Cells in lpr Mice: The Appendix in Normal Mice¹

Satoshi Yamagiwa^*, Satoshi Sugahara^*, Takao Shimizu^*, Toshihiko Iwanaga, Yuhei Yoshida^*, Shigeru Honda^*, Hisami Watanabe^*, Kenji Suzuki, Hitoshi Asakura and Toru Abo^2,*

^* Department of Immunology and Third Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan; and Department of Anatomy, Hokkaido University School of Agriculture, Sapporo, Japan

There have been no reports on an abundance of CD4^-8^-B220⁺ ß T cells, seen in autoimmune mice carrying the lpr gene (abnormal Fas gene), in any immune organs of normal mice. We herein report, however, that such ß T cells were abundant at intraepithelial sites of the appendix in normal mice. They lacked the expression of NK1.1 Ags (C57BL/6 mice), but had the morphology of granular lymphocytes and contained forbidden T cell clones in the minor lymphocyte-stimulating antigen (Mls) system (C3H/He mice with Mls-1^b2^a). In other words, many properties of intraepithelial T cells in the appendix resembled those ascribed to abnormal ß T cells, which expand in the lymph nodes and spleen of lpr mice. In the case of lpr mice, CD4^-8^-B220⁺ ß T cells first expanded in the appendix and then extended to other organs. CD4^-8^-B220⁺ ß T cells seemed to originate in situ from c-kit⁺ stem cells in the appendix. These results suggest that the appendix is one of the primary sites in which CD4^-8^-B220⁺ ß T cells exist, and that these cells carry many primordial properties as prototype T cells.

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