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Age-Dependent Appearance of NK1.1⁺ T Cells in the Livers of ß₂-Microglobulin Knockout and SJL Mice

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

NK1.1⁺ T cells, a specialized set of T cells that recognize CD1, are reportedly absent in young ß₂-microglobulin-deficient (ß₂m-knockout (KO)) and SJL mice. In this study, we show that a significant number of NK1.1⁺ T cells exist in the livers of older ß₂m-KO and SJL mice, and that the number of liver NK1.1⁺ T cells increases as the animals age. The surface phenotypes of liver NK1.1⁺ T cells from ß₂m-KO and SJL mice were similar to NK1.1⁺ T cells from C57BL/6 mice, except that the bulk of these cells were CD4^-CD8^-. After anti-CD3 injection in vivo, the cells promptly expressed IL-4 mRNA just as NK1.1⁺ T cells did in normal mice. Using L cells expressing CD1, liver NK1.1⁺ T cells from both ß₂m-KO and SJL mice were stimulated to proliferate, although to a lesser degree than were such cells from C57BL/6 mice. Our studies show that some NK1.1⁺ T cells accumulate in the livers of older ß₂m-KO and SJL mice, and that they appear to have functional properties similar to "normal" NK1.1⁺ T cells.

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