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B in Gastric Epithelial Cells1
,
*
Division of Infectious Diseases, Department of Medicine,
Department of Microbiology and Immunology, and
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232
In vivo, gastric infection with Helicobacter pylori
leads to substantial production of the inflammatory cytokines IL-1,
IL-6, TNF-
, and IL-8. H. pylori strains that contain the
cag pathogenicity island
(cag+) and are associated with
ulceration and gastric carcinoma induce greater cytokine production
than cag- strains. Expression of these
cytokines is often regulated by the transcription factor complex,
nuclear factor-
B (NF-B) through B-binding elements in the
enhancer/promoter regions of their genes. We report that more virulent
cag+ H. pylori strains induce
increased NF-B-DNA binding activity, which elevates IL-8 expression
in AGS gastric epithelial cells. The cag+
H. pylori strains induce significant stimulation of IL-8
promoter-driven reporter activity, while cag-
strains do not. Furthermore, mutation of specific genes within the
cag island (picA1 and picB)
ablates enhanced NF-B activation and IL-8 transcription. Increased
IL-8 expression is inhibited by mutation in either the NF-B or
NF-IL-6 binding element. The cag+ strains,
compared with the cag- strains, induce
enhanced nuclear localization of a RelA-containing NF-B binding
complex, but no increase in NF-IL-6 binding activity. These studies
demonstrate that the ability of different types of H.
pylori strains to activate NF-B correlates with their ability
to induce IL-8 transcription and indicate a mechanism for the
heightened inflammatory response seen in subjects infected with
cag+ H. pylori strains.
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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|
|
|
|
|
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|
|
|
|
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|
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|
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|
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|
|
|
|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
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|
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J. Wang, X. Fan, C. Lindholm, M. Bennett, J. O'Connoll, F. Shanahan, E. G. Brooks, V. E. Reyes, and P. B. Ernst Helicobacter pylori Modulates Lymphoepithelial Cell Interactions Leading to Epithelial Cell Damage through Fas/Fas Ligand Interactions Infect. Immun., July 1, 2000; 68(7): 4303 - 4311. [Abstract] [Full Text] [PDF]
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M. Gooz, C. E. Hammond, K. Larsen, Y. V. Mukhin, and A. J. Smolka Inhibition of human gastric H+-K+-ATPase alpha -subunit gene expression by Helicobacter pylori Am J Physiol Gastrointest Liver Physiol, June 1, 2000; 278(6): G981 - G991. [Abstract] [Full Text] [PDF]
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G R Van den Brink, K M A J Tytgat, R W M Van der Hulst, C M Van der Loos, A W C Einerhand, H A Buller, and J Dekker H pylori colocalises with MUC5AC in the human stomach Gut, May 1, 2000; 46(5): 601 - 607. [Abstract] [Full Text] [PDF]
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N. Mori, A. Wada, T. Hirayama, T. P. Parks, C. Stratowa, and N. Yamamoto Activation of Intercellular Adhesion Molecule 1 Expression by Helicobacter pylori Is Regulated by NF-kappa B in Gastric Epithelial Cancer Cells Infect. Immun., April 1, 2000; 68(4): 1806 - 1814. [Abstract] [Full Text] [PDF]
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G. R. van den Brink, F. J. ten Kate, C. Y. Ponsioen, M. M. Rive, G. N. Tytgat, S. J. H. van Deventer, and M. P. Peppelenbosch Expression and Activation of NF-{kappa}B in the Antrum of the Human Stomach J. Immunol., March 15, 2000; 164(6): 3353 - 3359. [Abstract] [Full Text] [PDF]
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J. Houghton, L. S. Macera-Bloch, L. Harrison, K. H. Kim, and R. M. Korah Tumor Necrosis Factor Alpha and Interleukin 1beta Up-Regulate Gastric Mucosal Fas Antigen Expression in Helicobacter pylori Infection Infect. Immun., March 1, 2000; 68(3): 1189 - 1195. [Abstract] [Full Text] [PDF]
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 M. Asahi, T. Azuma, S. Ito, Y. Ito, H. Suto, Y. Nagai, M. Tsubokawa, Y. Tohyama, S. Maeda, M. Omata, et al. Helicobacter pylori Caga Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells J. Exp. Med., February 21, 2000; 191(4): 593 - 602. [Abstract] [Full Text] [PDF]
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S. Wessler, M. Hocker, W. Fischer, T. C. Wang, S. Rosewicz, R. Haas, B. Wiedenmann, T. F. Meyer, and M. Naumann Helicobacter pylori Activates the Histidine Decarboxylase Promoter through a Mitogen-activated Protein Kinase Pathway Independent of Pathogenicity Island-encoded Virulence Factors J. Biol. Chem., February 4, 2000; 275(5): 3629 - 3636. [Abstract] [Full Text] [PDF]
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T. Tanahashi, M. Kita, T. Kodama, Y. Yamaoka, N. Sawai, T. Ohno, S. Mitsufuji, Y.-P. Wei, K. Kashima, and J. Imanishi Cytokine Expression and Production by Purified Helicobacter pylori Urease in Human Gastric Epithelial Cells Infect. Immun., February 1, 2000; 68(2): 664 - 671. [Abstract] [Full Text] [PDF]
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 M. Koyama, S. S. Spicer, and B. A. Schulte Distribution of I{kappa}B Proteins in Gastric Mucosa and Other Organs of Mouse and Gerbil J. Histochem. Cytochem., February 1, 2000; 48(2): 191 - 200. [Abstract] [Full Text]
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M. Stein, R. Rappuoli, and A. Covacci Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation PNAS, February 1, 2000; 97(3): 1263 - 1268. [Abstract] [Full Text] [PDF]
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R. M. Peek Jr., M. J. Blaser, D. J. Mays, M. H. Forsyth, T. L. Cover, S. Y. Song, U. Krishna, and J. A. Pietenpol Helicobacter pylori Strain-specific Genotypes and Modulation of the Gastric Epithelial Cell Cycle Cancer Res., December 1, 1999; 59(24): 6124 - 6131. [Abstract] [Full Text] [PDF]
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S. Keates, A. C. Keates, M. Warny, R. M. Peek Jr., P. G. Murray, and C. P. Kelly Differential Activation of Mitogen-Activated Protein Kinases in AGS Gastric Epithelial Cells by cag+ and cag- Helicobacter pylori J. Immunol., November 15, 1999; 163(10): 5552 - 5559. [Abstract] [Full Text] [PDF]
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M. Naumann, S. Wessler, C. Bartsch, B. Wieland, A. Covacci, R. Haas, and T. F. Meyer Activation of Activator Protein 1 and Stress Response Kinases in Epithelial Cells Colonized by Helicobacter pylori Encoding the cag Pathogenicity Island J. Biol. Chem., October 29, 1999; 274(44): 31655 - 31662. [Abstract] [Full Text] [PDF]
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S. D. Li, D. Kersulyte, I. J. D. Lindley, B. Neelam, D. E. Berg, and J. E. Crabtree Multiple Genes in the Left Half of the cag Pathogenicity Island of Helicobacter pylori Are Required for Tyrosine Kinase-Dependent Transcription of Interleukin-8 in Gastric Epithelial Cells Infect. Immun., August 1, 1999; 67(8): 3893 - 3899. [Abstract] [Full Text] [PDF]
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R. A. Gupta, D. B. Polk, U. Krishna, D. A. Israel, F. Yan, R. N. DuBois, and R. M. Peek Jr. Activation of Peroxisome Proliferator-activated Receptor gamma Suppresses Nuclear Factor kappa B-mediated Apoptosis Induced by Helicobacter pylori in Gastric Epithelial Cells J. Biol. Chem., August 10, 2001; 276(33): 31059 - 31066. [Abstract] [Full Text] [PDF]
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S. Maeda, M. Akanuma, Y. Mitsuno, Y. Hirata, K. Ogura, H. Yoshida, Y. Shiratori, and M. Omata Distinct Mechanism of Helicobacter pylori-mediated NF-kappa B Activation between Gastric Cancer Cells and Monocytic Cells J. Biol. Chem., November 21, 2001; 276(48): 44856 - 44864. [Abstract] [Full Text] [PDF]
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