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, -ß, and -
in Supporting the Lipopolysaccharide-Induced Transcription of IL-6 and Monocyte Chemoattractant Protein-11
*
Department of Microbiology, Michigan State University, East Lansing, MI 48824;
ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702; and
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430
C/EBP
, -ß, and -
are members of the CCAAT/enhancer binding
protein family of transcriptional regulators. All three of these
factors are expressed by bone marrow-derived macrophages, with the DNA
binding activity of C/EBPß and - increased by treatment with LPS
while that of C/EBP is decreased. We have ectopically expressed each
C/EBP protein in P388 lymphoblasts. The expression of any of these
transcription factors is sufficient to confer the LPS-inducible
expression of IL-6 and monocyte chemoattractant protein-1 to
lymphoblasts, which normally lack C/EBP factors and do not display LPS
induction of proinflammatory cytokines. Thus, the activities of
C/EBP, -ß, and - are redundant in regard to the expression of
IL-6 and monocyte chemoattractant protein-1. Since C/EBPß-deficient
mice have been reported to be largely normal in their expression of
proinflammatory cytokines, it is likely that the lack of C/EBPß is
compensated for by the induction of C/EBP upon LPS treatment.
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