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evi
*
*
Department of Immunology, Erasmus University, Rotterdam, The Netherlands;
CNRS ERS 107, Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, Université Pierre et Marie Curie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; and
Department of Cell Biology and Immunology, Free University, Amsterdam, The Netherlands
In the normal mouse spleen, two distinct populations of dendritic
cells (DC) are present that differ in microanatomical location. The
major population of marginal DC is found in the "marginal zone
bridging channels" and extends into the red pulp. The interdigitating
cells (IDC) are localized in the T cell areas in the white pulp. The
aim of the present study was to characterize these two splenic DC
populations with regard to their phenotype, in vivo phagocytic
function, and turnover. Both marginal DC and IDC are
CD11c+ and CD13+, but only IDC are
NLDC-145+ and CD8
+. Notably, both
populations, when freshly isolated, express the macrophage markers
F4/80, BM8, and Mac-1. To study the phagocytic capacity of these cells,
we employed the macrophage "suicide" technique by injecting
liposomes loaded with clodronate i.v. Marginal DC, but not IDC, were
eliminated by this treatment. Phagocytosis of DiI-labeled liposomes by
DC confirmed this finding. The two DC populations differed
significantly with regard to their turnover rates, as studied in a
transgenic mouse model of conditional depletion of DC populations with
high turnover. In these mice, marginal DC were completely eliminated,
but the IDC population remained virtually intact. From these data we
conclude that the marginal DC population has a high turnover, in
contrast to the IDC population. Taken together, the present results
indicate that marginal DC and IDC represent two essentially distinct
populations of DC in the mouse spleen. They differ not only in
location, but also in phenotype, phagocytic ability, and turnover.
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M. D. Gunn, S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L. T. Williams, and H. Nakano Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization J. Exp. Med., February 1, 1999; 189(3): 451 - 460. [Abstract] [Full Text] [PDF]
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L. Gorczynski, Z. Chen, J. Hu, Y. Kai, J. Lei, V. Ramakrishna, and R. M. Gorczynski Evidence That an OX-2-Positive Cell Can Inhibit the Stimulation of Type 1 Cytokine Production by Bone Marrow-Derived B7-1 (and B7-2)-Positive Dendritic Cells J. Immunol., January 15, 1999; 162(2): 774 - 781. [Abstract] [Full Text] [PDF]
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C. Masurier, B. Salomon, N. Guettari, C. Pioche, F. Lachapelle, M. Guigon, and D. Klatzmann Dendritic Cells Route Human Immunodeficiency Virus to Lymph Nodes after Vaginal or Intravenous Administration to Mice J. Virol., October 1, 1998; 72(10): 7822 - 7829. [Abstract] [Full Text] [PDF]
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B. N. Lambrecht, B. Salomon, D. Klatzmann, and R. A. Pauwels Dendritic Cells Are Required for the Development of Chronic Eosinophilic Airway Inflammation in Response to Inhaled Antigen in Sensitized Mice J. Immunol., April 15, 1998; 160(8): 4090 - 4097. [Abstract] [Full Text] [PDF]
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