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The Journal of Immunology, 1998, 160: 1982-1989.
Copyright © 1998 by The American Association of Immunologists

p38 Mitogen-Activated Protein Kinase Activation Is Required for Human Neutrophil Function Triggered by TNF-{alpha} or FMLP Stimulation1

You-Li Zu2,*, Jiafan Qi{dagger}, Annette Gilchrist§, Gustavo A. Fernandez*, Dolores Vazquez-Abad{ddagger}, Donald L. Kreutzer{dagger}, Chi-Kuang Huang{dagger} and Ramadan I. Sha’afi*

Departments of * Physiology, {dagger} Pathology, and {ddagger} Medicine, University of Connecticut Health Center, Farmington, CT 06030; and § Institute for Neuroscience, Northwestern University, Chicago, IL 60611

Mitogen-activated protein (MAP) kinase-mediated signal-transduction pathways convert extracellular stimulation into a variety of cellular functions. However, the roles of MAP kinases in neutrophils are not well understood yet. Protein phosphorylation analysis of cellular MAP kinases indicates that exposure of human neutrophils to chemotactic factor FMLP as well as granulocyte-macrophage CSF, PMA, or ionomycin rapidly induced the activation of p38 and p44/42 MAP kinases, but stimulation with inflammatory cytokine TNF-{alpha} triggered the activation of p38 MAP kinase only. To study the cellular functions of these MAP kinases, the inhibitor SB20358, which specifically inhibited enzymatic activity of cellular p38 MAP kinase, and the inhibitor PD98059, which specifically blocked the induced protein phosphorylation and activation of p44/42 MAP kinase in intact neutrophils, were utilized. Inhibition of the cellular p38 MAP kinase activation almost completely abolished the TNF-{alpha}-stimulated IL-8 production and superoxide generation of human neutrophils. In addition, the FMLP-induced neutrophil chemotaxis as well as superoxide generation were suppressed markedly by inhibiting the activation of cellular p38 MAP kinase, but not p44/42 MAP kinase. Moreover, RIA indicates that the activation of cellular p38 MAP kinase was required for the neutrophil IL-8 production stimulated by granulocyte-macrophage CSF or LPS as well as TNF-{alpha}, but not for that induced by PMA or ionomycin. These results demonstrate that the activation of cellular p38 MAP kinase is indispensable for the TNF-{alpha}- or FMLP-mediated cellular functions in human neutrophils, and suggest that p38 MAP kinase may play a different role in response to distinct stimulation.




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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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[Abstract] [Full Text] [PDF]


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J. Am. Soc. Nephrol., January 1, 2001; 12(1): 37 - 46.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Cell Physiol.Home page
J. A. Lehman, C. C. Paul, M. A. Baumann, and J. Gomez-Cambronero
MAP kinase upregulation after hematopoietic differentiation: role of chemotaxis
Am J Physiol Cell Physiol, January 1, 2001; 280(1): C183 - C191.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
C. Dewas, M. Fay, M.-A. Gougerot-Pocidalo, and J. El-Benna
The Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 Pathway Is Involved in formyl-Methionyl-Leucyl-Phenylalanine-Induced p47phox Phosphorylation in Human Neutrophils
J. Immunol., November 1, 2000; 165(9): 5238 - 5244.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
J. Jongstra-Bilen, V. L. Misener, C. Wang, H. Ginzberg, A. Auerbach, A. L. Joyner, G. P. Downey, and J. Jongstra
LSP1 modulates leukocyte populations in resting and inflamed peritoneum
Blood, September 1, 2000; 96(5): 1827 - 1835.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
T. Adachi, B. K. Choudhury, S. Stafford, S. Sur, and R. Alam
The Differential Role of Extracellular Signal-Regulated Kinases and p38 Mitogen-Activated Protein Kinase in Eosinophil Functions
J. Immunol., August 15, 2000; 165(4): 2198 - 2204.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
Q. Jing, S.-M. Xin, W.-B. Zhang, P. Wang, Y.-W. Qin, and G. Pei
Lysophosphatidylcholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis
Circ. Res., July 7, 2000; 87(1): 52 - 59.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
P. Y. Coxon, M. J. Rane, D. W. Powell, J. B. Klein, and K. R. McLeish
Differential Mitogen-Activated Protein Kinase Stimulation by Fc{gamma} Receptor IIa and Fc{gamma} Receptor IIIb Determines the Activation Phenotype of Human Neutrophils
J. Immunol., June 15, 2000; 164(12): 6530 - 6537.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
A. Mocsai, Z. Jakus, T. Vantus, G. Berton, C. A. Lowell, and E. Ligeti
Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein Kinase Activated by Src Family Kinases
J. Immunol., April 15, 2000; 164(8): 4321 - 4331.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. I. Simon, Y. Hu, D. Vestweber, and C. W. Smith
Neutrophil Tethering on E-Selectin Activates {beta}2 Integrin Binding to ICAM-1 Through a Mitogen-Activated Protein Kinase Signal Transduction Pathway
J. Immunol., April 15, 2000; 164(8): 4348 - 4358.
[Abstract] [Full Text] [PDF]


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Infect. Immun.Home page
E. A. Albanyan, J. G. Vallejo, C. W. Smith, and M. S. Edwards
Nonopsonic Binding of Type III Group B Streptococci to Human Neutrophils Induces Interleukin-8 Release Mediated by the p38 Mitogen-Activated Protein Kinase Pathway
Infect. Immun., April 1, 2000; 68(4): 2053 - 2060.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
J. A. Nick, S. K. Young, K. K. Brown, N. J. Avdi, P. G. Arndt, B. T. Suratt, M. S. Janes, P. M. Henson, and G. S. Worthen
Role of p38 Mitogen-Activated Protein Kinase in a Murine Model of Pulmonary Inflammation
J. Immunol., February 15, 2000; 164(4): 2151 - 2159.
[Abstract] [Full Text] [PDF]


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Arch SurgHome page
D. A. Partrick, E. E. Moore, P. J. Offner, D. R. Meldrum, D. Y. Tamura, J. L. Johnson, and C. C. Silliman
Maximal Human Neutrophil Priming for Superoxide Production and Elastase Release Requires p38 Mitogen-Activated Protein Kinase Activation
Arch Surg, February 1, 2000; 135(2): 219 - 225.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. Perskvist, L. Zheng, and O. Stendahl
Activation of Human Neutrophils by Mycobacterium tuberculosis H37Ra Involves Phospholipase C{gamma}2, Shc Adapter Protein, and p38 Mitogen-Activated Protein Kinase
J. Immunol., January 15, 2000; 164(2): 959 - 965.
[Abstract] [Full Text] [PDF]


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CVIHome page
I. Daniels, J. Fletcher, and A. P. Haynes
Role of p38 in the Priming of Human Neutrophils by Peritoneal Dialysis Effluent
Clin. Vaccine Immunol., November 1, 1999; 6(6): 878 - 884.
[Abstract] [Full Text] [PDF]


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J. Pharmacol. Exp. Ther.Home page
S. A. Wadsworth, D. E. Cavender, S. A. Beers, P. Lalan, P. H. Schafer, E. A. Malloy, W. Wu, B. Fahmy, G. C. Olini, J. E. Davis, et al.
RWJ 67657, a Potent, Orally Active Inhibitor of p38 Mitogen-Activated Protein Kinase
J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 680 - 687.
[Abstract] [Full Text]


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J. Immunol.Home page
J. P. Lian, R. Huang, D. Robinson, and J. A. Badwey
Activation of p90RSK and cAMP Response Element Binding Protein in Stimulated Neutrophils: Novel Effects of the Pyridinyl Imidazole SB 203580 on Activation of the Extracellular Signal-Regulated Kinase Cascade
J. Immunol., October 15, 1999; 163(8): 4527 - 4536.
[Abstract] [Full Text] [PDF]


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Arch SurgHome page
J. L. Johnson, E. E. Moore, D. A. Patrick, D. Y. Tamura, G. Zallen, D. J. Elzi, and C. C. Silliman
Extracellular Signal-Related Kinase 1/2 and p38 Mitogen-Activated Protein Kinase Pathways Serve Opposite Roles in Neutrophil Cytotoxicity
Arch Surg, October 1, 1999; 134(10): 1074 - 1078.
[Abstract] [Full Text] [PDF]


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BloodHome page
N. Geijsen, S. van Delft, J. A.M. Raaijmakers, J.-W. J. Lammers, J. G. Collard, L. Koenderman, and P. J. Coffer
Regulation of p21rac Activation in Human Neutrophils
Blood, August 1, 1999; 94(3): 1121 - 1130.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. B. Rizoli, O. D. Rotstein, and A. Kapus
Cell Volume-dependent Regulation of L-selectin Shedding in Neutrophils. A ROLE FOR p38 MITOGEN-ACTIVATED PROTEIN KINASE
J. Biol. Chem., July 30, 1999; 274(31): 22072 - 22080.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
R. M. Heuertz, S. M. Tricomi, U. R. Ezekiel, and R. O. Webster
C-reactive Protein Inhibits Chemotactic Peptide-induced p38 Mitogen-activated Protein Kinase Activity and Human Neutrophil Movement
J. Biol. Chem., June 18, 1999; 274(25): 17968 - 17974.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. Arbabi, I. Garcia, G. J. Bauer, and R. V. Maier
Alcohol (Ethanol) Inhibits IL-8 and TNF: Role of the p38 Pathway
J. Immunol., June 15, 1999; 162(12): 7441 - 7445.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
I. Feoktistov, A. E. Goldstein, and I. Biaggioni
Role of p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Protein Kinase Kinase in Adenosine A2B Receptor-Mediated Interleukin-8 Production in Human Mast Cells
Mol. Pharmacol., April 1, 1999; 55(4): 726 - 734.
[Abstract] [Full Text]


Home page
J. Immunol.Home page
K. K. Hale, D. Trollinger, M. Rihanek, and C. L. Manthey
Differential Expression and Activation of p38 Mitogen-Activated Protein Kinase {alpha}, {beta}, {gamma}, and {delta} in Inflammatory Cell Lineages
J. Immunol., April 1, 1999; 162(7): 4246 - 4252.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
D. D. Browning, N. D. Windes, and R. D. Ye
Activation of p38 Mitogen-activated Protein Kinase by Lipopolysaccharide in Human Neutrophils Requires Nitric Oxide-dependent cGMP Accumulation
J. Biol. Chem., January 1, 1999; 274(1): 537 - 542.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
R. Huang, J. P. Lian, D. Robinson, and J. A. Badwey
Neutrophils Stimulated with a Variety of Chemoattractants Exhibit Rapid Activation of p21-Activated Kinases (Paks): Separate Signals Are Required for Activation and Inactivation of Paks
Mol. Cell. Biol., December 1, 1998; 18(12): 7130 - 7138.
[Abstract] [Full Text]


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ScienceHome page
J. Chen, Y. Sun, and G. J. Nabel
Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)
Science, November 27, 1998; 282(5394): 1714 - 1717.
[Abstract] [Full Text]


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J. Immunol.Home page
J. P. Lian, R. Huang, D. Robinson, and J. A. Badwey
Products of Sphingolipid Catabolism Block Activation of the p21-Activated Protein Kinases in Neutrophils
J. Immunol., October 15, 1998; 161(8): 4375 - 4381.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
P. A. Detmers, D. Zhou, E. Polizzi, R. Thieringer, W. A. Hanlon, S. Vaidya, and V. Bansal
Role of Stress-Activated Mitogen-Activated Protein Kinase (p38) in {beta}2-Integrin-Dependent Neutrophil Adhesion and the Adhesion-Dependent Oxidative Burst
J. Immunol., August 15, 1998; 161(4): 1921 - 1929.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
R. A. Ward, M. Nakamura, and K. R. McLeish
Priming of the Neutrophil Respiratory Burst Involves p38 Mitogen-activated Protein Kinase-dependent Exocytosis of Flavocytochrome b558-containing Granules
J. Biol. Chem., November 17, 2000; 275(47): 36713 - 36719.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. Bechoua and L. W. Daniel
Phospholipase D Is Required in the Signaling Pathway Leading to p38 MAPK Activation in Neutrophil-like HL-60 Cells, Stimulated by N-Formyl-methionyl-leucyl-phenylalanine
J. Biol. Chem., August 17, 2001; 276(34): 31752 - 31759.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. E. Smolen, T. K. Petersen, C. Koch, S. J. O'Keefe, W. A. Hanlon, S. Seo, D. Pearson, M. C. Fossett, and S. I. Simon
L-Selectin Signaling of Neutrophil Adhesion and Degranulation Involves p38 Mitogen-activated Protein Kinase
J. Biol. Chem., May 19, 2000; 275(21): 15876 - 15884.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
O. Werz, J. Klemm, B. Samuelsson, and O. Radmark
5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
PNAS, May 9, 2000; 97(10): 5261 - 5266.
[Abstract] [Full Text] [PDF]




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