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Cell Clones Can Be Defined Phenotypically and Functionally as Th1/Th2 Cells and Illustrate the Association of CD4 with Th2 Differentiation1
*
Department of Biology and
Section of Immunobiology, Yale University, New Haven, CT 06511;
Imperial Cancer Research Fund Laboratories, London, United Kingdom
The division of CD4+ 
ß T cells into Th1 and
Th2 subsets has become an established and important paradigm. The
respective activities of these subsets appear to have profound effects
on the course of infectious and autoimmune diseases. It is believed
that specific programs of differentiation induce the commitment of an
uncommitted Th0 precursor cell to Th1 or Th2. A component of these
programs is hypothesized to be the nature of MHC-peptide antigen
presentation to the ß T cell. It has heretofore remained uncertain
whether a Th1/Th2 classification likewise defines, at the clonal level,
T cells. Such cells do not, as a general rule, express either
CD4 or CD8ß, and they do not commonly recognize peptide-MHC. In
this report, cell clones are described that conform strikingly
to the Th1/Th2 classification, both by cytokine expression and by
functional activities of the clones in vitro and in vivo.
Provocatively, both the cell clones and primary cells in
vivo showed a strong association of the Th2 phenotype with CD4
expression. These results are discussed with regard to the
immunoregulatory role that is increasingly emerging for cells.
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