| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,,
*
Neuroimmunobiology and Host Defense Laboratory, and
Neurotrauma Research Laboratory, Minneapolis Medical Research Foundation, and
University of Minnesota Medical School, Minneapolis, MN 55404
IL-8 involvement in neutrophil activation and chemotaxis may be
important in inflammatory responses within the central nervous system,
secondary to meningitis, encephalitis, and traumatic injury. The source
of IL-8 within the brain during these inflammatory processes, however,
is unknown. To explore the role of microglia in the production of IL-8,
human fetal microglia, which are the resident macrophages of the brain,
were treated with LPS and pro- and anti-inflammatory cytokines to
determine their effects on IL-8 production. We found that IL-8 protein
levels increased in response to LPS or IL-1ß, or to TNF-
, which
also corresponded to elevated IL-8 mRNA levels by RT-PCR. Pretreatment
with IL-4, IL-10, or TGF-ß1 potently inhibited the stimulatory
effects of these proinflammatory agents. These findings indicate that
human microglia synthesize IL-8 in response to proinflammatory stimuli,
and that anti-inflammatory cytokines down-regulate the production
of this chemokine. These results may have important therapeutic
implications for certain central nervous system insults involving
inflammation.
This article has been cited by other articles:
|
|
 |
|
  R. M. Mitchell, W. M. Freeman, W. T. Randazzo, H. E. Stephens, J. L. Beard, Z. Simmons, and J. R. Connor A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis Neurology, January 6, 2009; 72(1): 14 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Goczalik, E. Ulbricht, M. Hollborn, M. Raap, S. Uhlmann, M. Weick, T. Pannicke, P. Wiedemann, A. Bringmann, A. Reichenbach, et al. Expression of CXCL8, CXCR1, and CXCR2 in Neurons and Glial Cells of the Human and Rabbit Retina Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4578 - 4589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sekine, Y. Ouchi, G. Sugihara, N. Takei, E. Yoshikawa, K. Nakamura, Y. Iwata, K. J. Tsuchiya, S. Suda, K. Suzuki, et al. Methamphetamine Causes Microglial Activation in the Brains of Human Abusers J. Neurosci., May 28, 2008; 28(22): 5756 - 5761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. G. Zwijnenburg, T. van der Poll, J. J. Roord, and A. M. van Furth Chemotactic Factors in Cerebrospinal Fluid during Bacterial Meningitis Infect. Immun., March 1, 2006; 74(3): 1445 - 1451. [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Sheng, S. Hu, H. T. Ni, T. N. Rowen, J. R. Lokensgard, and P. K. Peterson TNF-{alpha}-induced chemokine production and apoptosis in human neural precursor cells J. Leukoc. Biol., December 1, 2005; 78(6): 1233 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Saeed, S. Varma, T. Peng, K. J. Tracey, B. Sherry, and C. N. Metz Ethanol Blocks Leukocyte Recruitment and Endothelial Cell Activation In Vivo and In Vitro J. Immunol., November 15, 2004; 173(10): 6376 - 6383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Rock, G. Gekker, S. Hu, W. S. Sheng, M. Cheeran, J. R. Lokensgard, and P. K. Peterson Role of Microglia in Central Nervous System Infections Clin. Microbiol. Rev., October 1, 2004; 17(4): 942 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C.-J. Cheeran, S. Hu, W. S. Sheng, P. K. Peterson, and J. R. Lokensgard CXCL10 Production from Cytomegalovirus-Stimulated Microglia Is Regulated by both Human and Viral Interleukin-10 J. Virol., April 15, 2003; 77(8): 4502 - 4515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mendez-Samperio, E. Garcia, A. Vazquez, and J. Palma Regulation of Interleukin-8 by Interleukin-10 and Transforming Growth Factor {beta} in Human Monocytes Infected with Mycobacterium bovis Clin. Vaccine Immunol., July 1, 2002; 9(4): 802 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gelati, E. Corsini, M. De Rossi, L. Masini, G. Bernardi, G. Massa, A. Boiardi, and A. Salmaggi Methylprednisolone Acts on Peripheral Blood Mononuclear Cells and Endothelium in Inhibiting Migration Phenomena in Patients With Multiple Sclerosis Arch Neurol, May 1, 2002; 59(5): 774 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Coombes and J. B. Mahony cDNA Array Analysis of Altered Gene Expression in Human Endothelial Cells in Response to Chlamydia pneumoniae Infection Infect. Immun., March 1, 2001; 69(3): 1420 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, S. Wei, J. Sun, D. Coppola, B. Zhong, G. D. Wu, B. Goodwin, S. Sebti, J. Y. Djeu, and G. Blanck Retinoblastoma Protein Activation of Interleukin 8 Expression Inhibits Tumor Cell Survival in Nude Mice Cell Growth Differ., December 1, 2000; 11(12): 635 - 639. [Abstract] [Full Text]
|
|
|
|
|
|
T. Jinquan, C. Jing, H. H. Jacobi, C. M. Reimert, A. Millner, S. Quan, J. B. Hansen, S. Dissing, H.-J. Malling, P. S. Skov, et al. CXCR3 Expression and Activation of Eosinophils: Role of IFN-{gamma}-Inducible Protein-10 and Monokine Induced by IFN-{gamma} J. Immunol., August 1, 2000; 165(3): 1548 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. SINGH, R. KULSHRESHTHA, and A. MATHUR Secretion of the chemokine interleukin-8 during Japanese encephalitis virus infection J. Med. Microbiol., July 1, 2000; 49(7): 607 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hu, H. Ali, W. S. Sheng, L. C. Ehrlich, P. K. Peterson, and C. C. Chao Gp-41-Mediated Astrocyte Inducible Nitric Oxide Synthase mRNA Expression: Involvement of Interleukin-1beta Production by Microglia J. Neurosci., August 1, 1999; 19(15): 6468 - 6474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ostergaard, T. Benfield, B. Gesser, A. Kharazmi, N. Frimodt-Moller, F. Espersen, and J. D. Lundgren Pretreatment with Granulocyte Colony-Stimulating Factor Attenuates the Inflammatory Response but Not the Bacterial Load in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits Infect. Immun., July 1, 1999; 67(7): 3430 - 3436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Saas, J. Boucraut, A.-L. Quiquerez, V. Schnuriger, G. Perrin, S. Desplat-Jego, D. Bernard, P. R. Walker, and P.-Y. Dietrich CD95 (Fas/Apo-1) as a Receptor Governing Astrocyte Apoptotic or Inflammatory Responses: A Key Role in Brain Inflammation? J. Immunol., February 15, 1999; 162(4): 2326 - 2333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Janabi, I. Hau, and M. Tardieu Negative Feedback Between Prostaglandin and {alpha}- and {beta}-Chemokine Synthesis in Human Microglial Cells and Astrocytes J. Immunol., February 1, 1999; 162(3): 1701 - 1706. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
