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The Journal of Immunology, 1998, 160: 1789-1795.
Copyright © 1998 by The American Association of Immunologists

Pentoxifylline Inhibits Ig {kappa} Gene Transcription and Rearrangements in Pre-B Cells1

Weihong Wang*, Satyajit Rath{dagger}, Jeannine M. Durdik{ddagger} and Ranjan Sen2,*

* Rosenstiel Research Center and Department of Biology, Brandeis University, Waltham, MA 02254; {dagger} National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India; and {ddagger} Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701

Pentoxifylline (PF) has been used in a wide variety of clinical situations; however, the molecular consequences of this drug are not well characterized. In this paper we assayed the effects of PF in two models of pre-B differentiation. In 70Z pre-B cells, transcriptional induction of rearranged Ig {kappa}-chain gene in response to LPS was suppressed by PF, without affecting the induction of Rel family proteins. In contrast, {kappa} induction by IFN-{gamma} was not suppressed by PF, indicating that the drug inhibited certain activation pathways. We also found that LPS-induced activation of germline {kappa} transcription and V{kappa} to J{kappa} recombination were inhibited by PF in the pre-B cell line 38B9. These observations suggest that PF may adversely affect B lymphopoiesis during chronic administration.







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