HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wang, W. Articles by Sen, R. Search for Related Content PubMed PubMed Citation Articles by Wang, W. Articles by Sen, R.

Pentoxifylline Inhibits Ig Gene Transcription and Rearrangements in Pre-B Cells¹

Weihong Wang^*, Satyajit Rath, Jeannine M. Durdik and Ranjan Sen^2,*

^* Rosenstiel Research Center and Department of Biology, Brandeis University, Waltham, MA 02254; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India; and Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701

Pentoxifylline (PF) has been used in a wide variety of clinical situations; however, the molecular consequences of this drug are not well characterized. In this paper we assayed the effects of PF in two models of pre-B differentiation. In 70Z pre-B cells, transcriptional induction of rearranged Ig -chain gene in response to LPS was suppressed by PF, without affecting the induction of Rel family proteins. In contrast, induction by IFN- was not suppressed by PF, indicating that the drug inhibited certain activation pathways. We also found that LPS-induced activation of germline transcription and V to J recombination were inhibited by PF in the pre-B cell line 38B9. These observations suggest that PF may adversely affect B lymphopoiesis during chronic administration.