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The Journal of Immunology, 1998, 160: 1694-1700.
Copyright © 1998 by The American Association of Immunologists

Antigen-Primed T Cells from B Cell-Deficient JHD Mice Fail to Provide B Cell Help1

Anne E. Macaulay, Rosemarie H. DeKruyff and Dale T. Umetsu2

Department of Pediatrics, Stanford University, Stanford, CA 94305

B cells are effective in presenting Ag to primed T cells, but a specific role for B cells in priming naive T cells has not been clearly established. In this report we demonstrate that Ag administration to B cell-deficient JHD mice primes T cells for Ag-specific proliferative responses, but such primed T cells fail to provide help for isotype switching and IgG production in B cells. Although T cells primed in the absence of B cells could proliferate in response to Ag presented by B cells and could induce Ag-specific IgM production, such T cells failed to produce high levels of IL-4 as are normally induced in T cells by Ag-presenting B cells. These findings suggest that while B cells are not absolutely required for T cell priming, they provide signals to T cells that are not replicated by other APCs and that influence the subsequent ability of T cells to interact with B cells.




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