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Schering-Plough, Laboratory for Immunological Research, Dardilly, France
In the present study, we have analyzed the pattern of cytokines
expressed by two independent dendritic cell (DC) subpopulations
generated in vitro from human cord blood CD34+
progenitors cultured with granulocyte-macrophage CSF and TNF-
.
Molecularly, we confirmed the phenotypic differences discriminating the
two subsets: E-cadherin mRNA was only detected in
CD1a+-derived DC, whereas CD68 and factor XIIIa mRNAs were
observed exclusively in CD14+-derived DC. Semiquantitative
reverse-transcriptase PCR analysis revealed that both DC subpopulations
spontaneously expressed IL-1, IL-1ß, IL-6, IL-7, IL-12 (p35 and
p40), IL-15, IL-18, TNF-, TGF-ß, macrophage CSF, and
granulocyte-macrophage CSF, but not IL-2, IL-3, IL-4, IL-5, IL-9, and
IFN-
transcripts. Both subpopulations were shown to secrete IL-12
after CD40 triggering. Interestingly, only the
CD14+-derived DC secreted IL-10 after CD40 activation,
strengthening the notion that the two DC subpopulations indeed
represent two independent pathways of DC development. Furthermore, both
DC subpopulations expressed IL-13 mRNA and protein following activation
with PMA-ionomycin, but not with CD40 ligand, in contrast to IL-12 and
IL-10, revealing the existence of different pathways for DC activation.
Finally, we confirmed the expression of IL-7, IL-10, and IL-13 mRNA by
CD4+CD11c+CD3- DC isolated ex vivo
from tonsillar germinal centers. Thus, CD14+-derived DC
expressing IL-10 and factor XIIIa seemed more closely related to
germinal center dendritic cellsGCDC than to Langerhans
cells.
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B. Canque, S. Camus, A. Dalloul, E. Kahn, M. Yagello, C. Dezutter-Dambuyant, D. Schmitt, C. Schmitt, and J. C. Gluckman Characterization of dendritic cell differentiation pathways from cord blood CD34+CD7+CD45RA+ hematopoietic progenitor cells Blood, December 1, 2000; 96(12): 3748 - 3756. [Abstract] [Full Text] [PDF]
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S. Thoma-Uszynski, S. M. Kiertscher, M. T. Ochoa, D. A. Bouis, M. V. Norgard, K. Miyake, P. J. Godowski, M. D. Roth, and R. L. Modlin Activation of Toll-Like Receptor 2 on Human Dendritic Cells Triggers Induction of IL-12, But Not IL-10 J. Immunol., October 1, 2000; 165(7): 3804 - 3810. [Abstract] [Full Text] [PDF]
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C. Soulas, T. Baussant, J.-P. Aubry, Y. Delneste, N. Barillat, G. Caron, T. Renno, J.-Y. Bonnefoy, and P. Jeannin Cutting Edge: Outer Membrane Protein A (OmpA) Binds to and Activates Human Macrophages J. Immunol., September 1, 2000; 165(5): 2335 - 2340. [Abstract] [Full Text] [PDF]
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 P. Brossart, A. Zobywalski, F. Grünebach, L. Behnke, G. Stuhler, V. L. Reichardt, L. Kanz, and W. Brugger Tumor Necrosis Factor {{alpha}} and CD40 Ligand Antagonize the Inhibitory Effects of Interleukin 10 on T-Cell Stimulatory Capacity of Dendritic Cells Cancer Res., August 1, 2000; 60(16): 4485 - 4492. [Abstract] [Full Text]
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E. Riedl, J. Stockl, O. Majdic, C. Scheinecker, K. Rappersberger, W. Knapp, and H. Strobl Functional Involvement of E-Cadherin in TGF-{beta}1-Induced Cell Cluster Formation of In Vitro Developing Human Langerhans-Type Dendritic Cells J. Immunol., August 1, 2000; 165(3): 1381 - 1386. [Abstract] [Full Text] [PDF]
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P. Jourdan, J.-P. Vendrell, M.-F. Huguet, M. Segondy, J. Bousquet, J. Pene, and H. Yssel Cytokines and Cell Surface Molecules Independently Induce CXCR4 Expression on CD4+ CCR7+ Human Memory T Cells J. Immunol., July 15, 2000; 165(2): 716 - 724. [Abstract] [Full Text] [PDF]
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H. Nagayama, K. Sato, H. Kawasaki, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, S. Asano, and T. A. Takahashi IL-12 Responsiveness and Expression of IL-12 Receptor in Human Peripheral Blood Monocyte-Derived Dendritic Cells J. Immunol., July 1, 2000; 165(1): 59 - 66. [Abstract] [Full Text] [PDF]
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D. Rea, C. van Kooten, K. E. van Meijgaarden, T. H. M. Ottenhoff, C. J. M. Melief, and R. Offringa Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10 Blood, May 15, 2000; 95(10): 3162 - 3167. [Abstract] [Full Text] [PDF]
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C. G. Feng, W. J. Britton, U. Palendira, N. L. Groat, H. Briscoe, and A. G. D. Bean Up-Regulation of VCAM-1 and Differential Expansion of {beta} Integrin-Expressing T Lymphocytes Are Associated with Immunity to Pulmonary Mycobacterium tuberculosis Infection J. Immunol., May 1, 2000; 164(9): 4853 - 4860. [Abstract] [Full Text] [PDF]
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A. Matsukawa, C. M. Hogaboam, N. W. Lukacs, P. M. Lincoln, H. L. Evanoff, R. M. Strieter, and S. L. Kunkel Expression and Contribution of Endogenous IL-13 in an Experimental Model of Sepsis J. Immunol., March 1, 2000; 164(5): 2738 - 2744. [Abstract] [Full Text] [PDF]
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B. Johansson, S. Ingvarsson, P. Bjorck, and C. A. K. Borrebaeck Human Interdigitating Dendritic Cells Induce Isotype Switching and IL-13-Dependent IgM Production in CD40-Activated Naive B Cells J. Immunol., February 15, 2000; 164(4): 1847 - 1854. [Abstract] [Full Text] [PDF]
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A. Khanna, A. E. Morelli, C. Zhong, T. Takayama, L. Lu, and A. W. Thomson Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo J. Immunol., February 1, 2000; 164(3): 1346 - 1354. [Abstract] [Full Text] [PDF]
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 M. Brenner, C. Rossig, U. Sili, J. W. Young, and E. Goulmy Transfusion Medicine: New Clinical Applications of Cellular Immunotherapy Hematology, January 1, 2000; 2000(1): 356 - 375. [Abstract] [Full Text] [PDF]
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A. Galy, I. Christopherson, G. Ferlazzo, G. Liu, H. Spits, and K. Georgopoulos Distinct signals control the hematopoiesis of lymphoid-related dendritic cells Blood, January 1, 2000; 95(1): 128 - 137. [Abstract] [Full Text] [PDF]
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 D. Rea, F. H. E. Schagen, R. C. Hoeben, M. Mehtali, M. J. E. Havenga, R. E. M. Toes, C. J. M. Melief, and R. Offringa Adenoviruses Activate Human Dendritic Cells without Polarization toward a T-Helper Type 1-Inducing Subset J. Virol., December 1, 1999; 73(12): 10245 - 10253. [Abstract] [Full Text]
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A. Aicher, G. L. Shu, D. Magaletti, T. Mulvania, A. Pezzutto, A. Craxton, and E. A. Clark Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells J. Immunol., December 1, 1999; 163(11): 5786 - 5795. [Abstract] [Full Text] [PDF]
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S. Nakagawa, C. W. Koomen, J. D. Bos, and M. B. M. Teunissen Differential Modulation of Human Epidermal Langerhans Cell Maturation by Ultraviolet B Radiation J. Immunol., November 15, 1999; 163(10): 5192 - 5200. [Abstract] [Full Text] [PDF]
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 E. L. NELSON, S. STROBL, J. SUBLESKI, D. PRIETO, W. C. KOPP, and P. J. NELSON Cycling of human dendritic cell effector phenotypes in response to TNF-{alpha}: modification of the current `maturation' paradigm and implications for in vivo immunoregulation FASEB J, November 1, 1999; 13(14): 2021 - 2030. [Abstract] [Full Text]
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S. Jaksits, E. Kriehuber, A. S. Charbonnier, K. Rappersberger, G. Stingl, and D. Maurer CD34+ Cell-Derived CD14+ Precursor Cells Develop into Langerhans Cells in a TGF-{beta}1-Dependent Manner J. Immunol., November 1, 1999; 163(9): 4869 - 4877. [Abstract] [Full Text] [PDF]
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S. Corinti, D. Medaglini, A. Cavani, M. Rescigno, G. Pozzi, P. Ricciardi-Castagnoli, and G. Girolomoni Human Dendritic Cells Very Efficiently Present a Heterologous Antigen Expressed on the Surface of Recombinant Gram-Positive Bacteria to CD4+ T Lymphocytes J. Immunol., September 15, 1999; 163(6): 3029 - 3036. [Abstract] [Full Text] [PDF]
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Y. Delneste, N. Herbault, B. Galea, G. Magistrelli, I. Bazin, J.-Y. Bonnefoy, and P. Jeannin Vasoactive Intestinal Peptide Synergizes with TNF-{alpha} in Inducing Human Dendritic Cell Maturation J. Immunol., September 15, 1999; 163(6): 3071 - 3075. [Abstract] [Full Text] [PDF]
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R. Sacedon, A. Vicente, A. Varas, E. Jimenez, J. J. Munoz, and A. G. Zapata Glucocorticoid-mediated regulation of thymic dendritic cell function Int. Immunol., August 1, 1999; 11(8): 1217 - 1224. [Abstract] [Full Text] [PDF]
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C. Chougnet, S. S. Cohen, T. Kawamura, A. L. Landay, H. A. Kessler, E. Thomas, A. Blauvelt, and G. M. Shearer Normal Immune Function of Monocyte-Derived Dendritic Cells from HIV-Infected Individuals: Implications for Immunotherapy J. Immunol., August 1, 1999; 163(3): 1666 - 1673. [Abstract] [Full Text] [PDF]
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S. Corinti, E. Fanales-Belasio, C. Albanesi, A. Cavani, P. Angelisova, and G. Girolomoni Cross-Linking of Membrane CD43 Mediates Dendritic Cell Maturation J. Immunol., June 1, 1999; 162(11): 6331 - 6336. [Abstract] [Full Text] [PDF]
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B. Canque, Y. Bakri, S. Camus, M. Yagello, A. Benjouad, and J. C. Gluckman The Susceptibility to X4 and R5 Human Immunodeficiency Virus-1 Strains of Dendritic Cells Derived In Vitro From CD34+ Hematopoietic Progenitor Cells Is Primarily Determined by Their Maturation Stage Blood, June 1, 1999; 93(11): 3866 - 3875. [Abstract] [Full Text] [PDF]
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F. Geissmann, P. Revy, A. Regnault, Y. Lepelletier, M. Dy, N. Brousse, S. Amigorena, O. Hermine, and A. Durandy TGF-{beta}1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells J. Immunol., April 15, 1999; 162(8): 4567 - 4575. [Abstract] [Full Text] [PDF]
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P. Kalinski, J. H. N. Schuitemaker, C. M. U. Hilkens, E. A. Wierenga, and M. L. Kapsenberg Final Maturation of Dendritic Cells Is Associated with Impaired Responsiveness to IFN-{gamma} and to Bacterial IL-12 Inducers: Decreased Ability of Mature Dendritic Cells to Produce IL-12 During the Interaction with Th Cells J. Immunol., March 15, 1999; 162(6): 3231 - 3236. [Abstract] [Full Text] [PDF]
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B. Dubois, C. Barthelemy, I. Durand, Y.-J. Liu, C. Caux, and F. Briere Toward a Role of Dendritic Cells in the Germinal Center Reaction: Triggering of B Cell Proliferation and Isotype Switching J. Immunol., March 15, 1999; 162(6): 3428 - 3436. [Abstract] [Full Text] [PDF]
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R. Josien, B. R. Wong, H.-L. Li, R. M. Steinman, and Y. Choi TRANCE, a TNF Family Member, Is Differentially Expressed on T Cell Subsets and Induces Cytokine Production in Dendritic Cells J. Immunol., March 1, 1999; 162(5): 2562 - 2568. [Abstract] [Full Text] [PDF]
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P. A. Stumbles, J. A. Thomas, C. L. Pimm, P. T. Lee, T. J. Venaille, S. Proksch, and P. G. Holt Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity J. Exp. Med., December 7, 1998; 188(11): 2019 - 2031. [Abstract] [Full Text] [PDF]
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B. Dubois, C. Massacrier, B. Vanbervliet, J. Fayette, F. Briere, J. Banchereau, and C. Caux Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes J. Immunol., September 1, 1998; 161(5): 2223 - 2231. [Abstract] [Full Text] [PDF]
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