| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratoire de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, Paris, France
T lymphocyte responses to a protein Ag are restricted to a limited number of determinants and not to all peptides capable of binding to MHC class II molecules. This focusing of the immune response is defined as immunodominance and has been observed with numerous protein Ags. In the H-2d haplotype, hen egg-white lysozyme (HEL)-specific T lymphocytes react with I-Ed-restricted peptides derived from a single immunodominant (ID) region (HEL 103–117). Moreover, we have recently found that another region of HEL (HEL 7–31) binds to I-Ad molecules and is efficiently processed and presented by splenocytes. HEL7-31 is as tolerogenic as the ID region in HEL transgenic mice. The present report demonstrates that the subdominance of the HEL 7–31 region is not due to a defect in the T cell repertoire, since specific TCRs can be found in all BALB/c mice. We show that normal and lymphoma B cells present efficiently HEL regions 103–117 and 7–31, whereas dendritic cells favor the ID region only. These results suggest that dendritic cells play a major role in the focusing of the immune response against a few antigenic determinants, while B lymphocytes may diversify the T cell response by presenting a more heterogeneous set of peptide-MHC complexes.
This article has been cited by other articles:
|
|
 |
|
  P. R. Menges, S. A. Jenks, E. K. Bikoff, D. R. Friedmann, Z. A. G. Knowlden, and A. J. Sant An MHC Class II Restriction Bias in CD4 T Cell Responses toward I-A Is Altered to I-E in DM-Deficient Mice J. Immunol., February 1, 2008; 180(3): 1619 - 1633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fazilleau, J.-P. Cabaniols, F. Lemaitre, I. Motta, P. Kourilsky, and J. M. Kanellopoulos V{alpha} and V{beta} Public Repertoires Are Highly Conserved in Terminal Deoxynucleotidyl Transferase-Deficient Mice J. Immunol., January 1, 2005; 174(1): 345 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Attanavanich and J. F. Kearney Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells J. Immunol., January 15, 2004; 172(2): 803 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lore, M. R. Betts, J. M. Brenchley, J. Kuruppu, S. Khojasteh, S. Perfetto, M. Roederer, R. A. Seder, and R. A. Koup Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses J. Immunol., October 15, 2003; 171(8): 4320 - 4328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawahata, Y. Misaki, M. Yamauchi, S. Tsunekawa, K. Setoguchi, J.-i. Miyazaki, and K. Yamamoto Peripheral Tolerance to a Nuclear Autoantigen: Dendritic Cells Expressing a Nuclear Autoantigen Lead to Persistent Anergic State of CD4+ Autoreactive T Cells After Proliferation J. Immunol., February 1, 2002; 168(3): 1103 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Matsuda, L. Gapin, N. Fazilleau, K. Warren, O. V. Naidenko, and M. Kronenberg Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size PNAS, October 5, 2001; (2001) 221445298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Y. Choi, Y. Yoshimura, G. J. Christianson, T. J. Sproule, S. Malarkannan, N. Shastri, S. Joyce, and D. C. Roopenian Quantitative Analysis of the Immune Response to Mouse Non-MHC Transplantation Antigens In Vivo: The H60 Histocompatibility Antigen Dominates Over All Others J. Immunol., April 1, 2001; 166(7): 4370 - 4379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shimizu, E. K. Thomas, M. Giedlin, and J. J. Mulé Enhancement of Tumor Lysate- and Peptide-pulsed Dendritic Cell-based Vaccines by the Addition of Foreign Helper Protein Cancer Res., March 1, 2001; 61(6): 2618 - 2624. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Podmore, J.L. Ebersole, and D.F. Kinane Immunodominant Antigens in Periodontal Disease: a Real or Illusive Concept? Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(2): 179 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Laouini, A. Casrouge, S. Dalle, F. Lemonnier, P. Kourilsky, and J. Kanellopoulos V{beta} T Cell Repertoire of CD8+ Splenocytes Selected on Nonpolymorphic MHC Class I Molecules J. Immunol., December 1, 2000; 165(11): 6381 - 6386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Nanda and A. J. Sant DM Determines the Cryptic and Immunodominant Fate of T Cell Epitopes J. Exp. Med., September 11, 2000; 192(6): 781 - 788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Delves and I. M. Roitt The Immune System- Second of Two Parts N. Engl. J. Med., July 13, 2000; 343(2): 108 - 117. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wienhold, G. Malcherek, C. Jung, S. Stevanovic, G. Jung, H. Schild, and A. Melms An example of immunodominance: engagement of synonymous TCR by invariant CDR3{beta} Int. Immunol., June 1, 2000; 12(6): 747 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Matsuda, L. Gapin, B. C. Sydora, F. Byrne, S. Binder, M. Kronenberg, and R. Aranda Systemic Activation and Antigen-Driven Oligoclonal Expansion of T Cells in a Mouse Model of Colitis J. Immunol., March 1, 2000; 164(5): 2797 - 2806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Foucras, L. Gapin, C. Coureau, J. M. Kanellopoulos, and J.-C. Guery Interleukin 4-producing CD4 T Cells Arise from Different Precursors Depending on the Conditions of Antigen Exposure In Vivo J. Exp. Med., February 21, 2000; 191(4): 683 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cambiaggi, S. Darche, S. Guia, P. Kourilsky, J.-P. Abastado, and E. Vivier Modulation of T-Cell Functions in KIR2DL3 (CD158b) Transgenic Mice Blood, October 1, 1999; 94(7): 2396 - 2402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-K. Kim, M. Angevine, K. Demick, L. Ortiz, R. Rudersdorf, D. Watkins, and R. DeMars Induction of HLA Class I-Restricted CD8+ CTLs Specific for the Major Outer Membrane Protein of Chlamydia trachomatis in Human Genital Tract Infections J. Immunol., June 1, 1999; 162(11): 6855 - 6866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Coutinho-Silva, P. M. Persechini, R. D. C. Bisaggio, J.-L. Perfettini, A. C. T. D. S. Neto, J. M. Kanellopoulos, I. Motta-Ly, A. Dautry-Varsat, and D. M. Ojcius P2Z/P2X7 receptor-dependent apoptosis of dendritic cells Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1139 - C1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Carson, D. D. Desai, K. M. Vignali, and D. A. A. Vignali2 Cutting Edge: Immunoregulation of Th Cells by Naturally Processed Peptide Antagonists J. Immunol., January 1, 1999; 162(1): 1 - 4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Drakesmith, D. O'Neil, S. C. Schneider, M. Binks, P. Medd, E. Sercarz, P. Beverley, and B. Chain In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen PNAS, December 8, 1998; 95(25): 14903 - 14908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gapin, Y. Fukui, J. Kanellopoulos, T. Sano, A. Casrouge, V. Malier, E. Beaudoing, D. Gautheret, J.-M. Claverie, T. Sasazuki, et al. Quantitative Analysis of the T Cell Repertoire Selected by a Single Peptide-Major Histocompatibility Complex J. Exp. Med., June 1, 1998; 187(11): 1871 - 1883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Dai, S. Carmicle, N. K. Steede, and S. J. Landry Structural Basis for Helper T-cell and Antibody Epitope Immunodominance in Bacteriophage T4 Hsp10. ROLE OF DISORDERED LOOPS J. Biol. Chem., January 4, 2002; 277(1): 161 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Matsuda, L. Gapin, N. Fazilleau, K. Warren, O. V. Naidenko, and M. Kronenberg Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size PNAS, October 23, 2001; 98(22): 12636 - 12641. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
