| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Plays a Critical Role in Maintaining Secondary Immunity in the Absence of IFN-
*
Lymphokine Regulation Unit, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and
Veterinary Resources Program, National Center for Research Resources, National Institutes of Health, Bethesda, MD 20892
Primary infection to Histoplasma capsulatum often
results in a self-limited upper respiratory infection in humans;
however, in immunocompromised hosts, disseminated infection can occur
through reactivation of a previous infection. Since disseminated
histoplasmosis has emerged as a difficult clinical entity to treat in
individuals infected with HIV, it was of interest to study the
mechanisms involved in maintaining an effective memory immune response.
It has been previously shown in a murine model of disseminated
histoplasmosis that IL-12, IFN-
, and TNF-
were important factors
in mediating primary protection. To study whether these and other
factors were involved in maintaining a protective immune response
following secondary infection, normal C57BL/6 mice were first infected
with a sublethal dose of H. capsulatum (1 x
105) and then reinfected 3 wk later with a lethal dose of
H. capsulatum (6 x 105). Under these
conditions, all mice developed an effective immune response with
sterilizing immunity. Moreover, normal C57BL/6 mice treated with
neutralizing Abs against either IL-12, TNF-, or IFN-, depleted of
neutrophils or treated with aminoguanidine at the time of reinfection,
maintained an effective immune response. The ability of animals to
survive a secondary infection in the absence of IFN- was verified by
showing that IFN--/- mice previously immunized with
H. capsulatum and treated with amphotericin B at the time
of primary infection had prolonged survival following reinfection with
a normally lethal dose. It was further shown that enhancement of
TNF- production in IFN--/- mice was the major
mechanism by which these mice were effective in controlling secondary
infection.
This article has been cited by other articles:
|
|
 |
|
  G. S. Deepe Jr, R. S. Gibbons, and A. G. Smulian Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs J. Leukoc. Biol., September 1, 2008; 84(3): 669 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Shi, P. C. Albuquerque, E. Lazar-Molnar, X. Wang, L. Santambrogio, A. Gacser, and J. D. Nosanchuk A Monoclonal Antibody to Histoplasma capsulatum Alters the Intracellular Fate of the Fungus in Murine Macrophages Eukaryot. Cell, July 1, 2008; 7(7): 1109 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lazar-Molnar, A. Gacser, G. J. Freeman, S. C. Almo, S. G. Nathenson, and J. D. Nosanchuk The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum PNAS, February 19, 2008; 105(7): 2658 - 2663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tsiodras, G. Samonis, D. T. Boumpas, and D. P. Kontoyiannis Fungal Infections Complicating Tumor Necrosis Factor {alpha} Blockade Therapy Mayo Clin. Proc., February 1, 2008; 83(2): 181 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Deepe Jr. and R. S. Gibbons TNF-{alpha} Antagonism Generates a Population of Antigen-Specific CD4+CD25+ T Cells That Inhibit Protective Immunity in Murine Histoplasmosis J. Immunol., January 15, 2008; 180(2): 1088 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Allen and G. S. Deepe Jr. B Cells and CD4-CD8- T Cells Are Key Regulators of the Severity of Reactivation Histoplasmosis J. Immunol., August 1, 2006; 177(3): 1763 - 1771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Subauste and M. Wessendarp CD40 Restrains In Vivo Growth of Toxoplasma gondii Independently of Gamma Interferon Infect. Immun., March 1, 2006; 74(3): 1573 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Hamilton Immunosuppression Related to Collagen-Vascular Disease or Its Treatment Proceedings of the ATS, December 1, 2005; 2(5): 456 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Andrade, M. Wessendarp, J.-A. C. Portillo, J.-Q. Yang, F. J. Gomez, J. E. Durbin, G. A. Bishop, and C. S. Subauste TNF Receptor-Associated Factor 6-Dependent CD40 Signaling Primes Macrophages to Acquire Antimicrobial Activity in Response to TNF-{alpha} J. Immunol., November 1, 2005; 175(9): 6014 - 6021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wuthrich, T. Warner, and B. S. Klein IL-12 Is Required for Induction but Not Maintenance of Protective, Memory Responses to Blastomyces dermatitidis: Implications for Vaccine Development in Immune-Deficient Hosts J. Immunol., October 15, 2005; 175(8): 5288 - 5297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. S. Dhabhar and K. Viswanathan Short-term stress experienced at time of immunization induces a long-lasting increase in immunologic memory Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R738 - R744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Andrade, J.-A. C. Portillo, M. Wessendarp, and C. S. Subauste CD40 Signaling in Macrophages Induces Activity against an Intracellular Pathogen Independently of Gamma Interferon and Reactive Nitrogen Intermediates Infect. Immun., May 1, 2005; 73(5): 3115 - 3123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-K. Peng, J.-S. Lin, J. T. Kung, F. D. Finkelman, and B. A. Wu-Hsieh The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection Int. Immunol., February 1, 2005; 17(2): 193 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Medeiros, A. Sa-Nunes, E. G. Soares, C. M. Peres, C. L. Silva, and L. H. Faccioli Blockade of Endogenous Leukotrienes Exacerbates Pulmonary Histoplasmosis Infect. Immun., March 1, 2004; 72(3): 1637 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Andrade, M. Wessendarp, and C. S. Subauste CD154 Activates Macrophage Antimicrobial Activity in the Absence of IFN-{gamma} through a TNF-{alpha}-Dependent Mechanism J. Immunol., December 15, 2003; 171(12): 6750 - 6756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Deepe Jr. and R. S. Gibbons Protective and Memory Immunity to Histoplasma capsulatum in the Absence of IL-10 J. Immunol., November 15, 2003; 171(10): 5353 - 5362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Gildea, R. Gibbons, F. D. Finkelman, and G. S. Deepe Jr. Overexpression of Interleukin-4 in Lungs of Mice Impairs Elimination of Histoplasma capsulatum Infect. Immun., July 1, 2003; 71(7): 3787 - 3793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Wood, C. A. Hage, K. S. Knox, M. B. Kleiman, A. Sannuti, R. B. Day, L. J. Wheat, and H. L. Twigg III Histoplasmosis after Treatment with Anti-Tumor Necrosis Factor-{alpha} Therapy Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1279 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sisto, A. Miluzio, O. Leopardi, M. Mirra, J. R. Boelaert, and D. Taramelli Differential Cytokine Pattern in the Spleens and Livers of BALB/c Mice Infected with Penicillium marneffei: Protective Role of Gamma Interferon Infect. Immun., January 1, 2003; 71(1): 465 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wuthrich, H. I. Filutowicz, T. Warner, and B. S. Klein Requisite Elements in Vaccine Immunity to Blastomyces dermatitidis: Plasticity Uncovers Vaccine Potential in Immune-Deficient Hosts J. Immunol., December 15, 2002; 169(12): 6969 - 6976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Deepe, Jr., and R. S. Gibbons Cellular and Molecular Regulation of Vaccination with Heat Shock Protein 60 from Histoplasma capsulatum Infect. Immun., July 1, 2002; 70(7): 3759 - 3767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Finkel-Jimenez, M. Wuthrich, and B. S. Klein BAD1, an Essential Virulence Factor of Blastomyces dermatitidis, Suppresses Host TNF-{alpha} Production Through TGF-{beta}-Dependent and -Independent Mechanisms J. Immunol., June 1, 2002; 168(11): 5746 - 5755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Stromnes, U. Dittmer, T. N. M. Schumacher, K. Schepers, R. J. Messer, L. H. Evans, K. E. Peterson, B. Race, and K. J. Hasenkrug Temporal Effects of Gamma Interferon Deficiency on the Course of Friend Retrovirus Infection in Mice J. Virol., March 1, 2002; 76(5): 2225 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Wu-Hsieh, J. K. Whitmire, R. de Fries, J.-S. Lin, M. Matloubian, and R. Ahmed Distinct CD8 T Cell Functions Mediate Susceptibility to Histoplasmosis During Chronic Viral Infection J. Immunol., October 15, 2001; 167(8): 4566 - 4573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Deepe Jr. and R. Gibbons V{beta}6+ T Cells Are Obligatory for Vaccine-Induced Immunity to Histoplasma capsulatum J. Immunol., August 15, 2001; 167(4): 2219 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Deepe Jr. and R. Gibbons Protective Efficacy of H Antigen from Histoplasma capsulatum in a Murine Model of Pulmonary Histoplasmosis Infect. Immun., May 1, 2001; 69(5): 3128 - 3134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Zhou, B. L. Freidag, C. C. Caldwell, and R. A. Seder Perforin Is Required for Primary Immunity to Histoplasma capsulatum J. Immunol., February 1, 2001; 166(3): 1968 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Gildea, R. E. Morris, and S. L. Newman Histoplasma capsulatum Yeasts Are Phagocytosed Via Very Late Antigen-5, Killed, and Processed for Antigen Presentation by Human Dendritic Cells J. Immunol., January 15, 2001; 166(2): 1049 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Deepe Jr. and R. Gibbons Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor Modulates the Course of Pulmonary Histoplasmosis in Immunocompetent and Immunodeficient Mice Antimicrob. Agents Chemother., December 1, 2000; 44(12): 3328 - 3336. [Abstract] [Full Text]
|
|
|
|
|
|
G. H. Chen, R. C. Reddy, M. W. Newstead, K. Tateda, B. L. Kyasapura, and T. J. Standiford Intrapulmonary TNF Gene Therapy Reverses Sepsis-Induced Suppression of Lung Antibacterial Host Defense J. Immunol., December 1, 2000; 165(11): 6496 - 6503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Allendoerfer and G. S. Deepe Jr. Regulation of Infection with Histoplasma capsulatum by TNFR1 and -2 J. Immunol., September 1, 2000; 165(5): 2657 - 2664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Yap, M. Pesin, and A. Sher Cutting Edge: IL-12 Is Required for the Maintenance of IFN-{gamma} Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen, Toxoplasma gondii J. Immunol., July 15, 2000; 165(2): 628 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Murray and S. Delph-Etienne Roles of Endogenous Gamma Interferon and Macrophage Microbicidal Mechanisms in Host Response to Chemotherapy in Experimental Visceral Leishmaniasis Infect. Immun., January 1, 2000; 68(1): 288 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Deepe Jr., R. Gibbons, and E. Woodward Neutralization of Endogenous Granulocyte-Macrophage Colony-Stimulating Factor Subverts the Protective Immune Response to Histoplasma capsulatum J. Immunol., November 1, 1999; 163(9): 4985 - 4993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bliss, Y. Zhang, and E. Y. Denkers Murine Neutrophil Stimulation by Toxoplasma gondii Antigen Drives High Level Production of IFN-{gamma}-Independent IL-12 J. Immunol., August 15, 1999; 163(4): 2081 - 2088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Allendorfer, G. D. Brunner, and G. S. Deepe Jr. Complex Requirements for Nascent and Memory Immunity in Pulmonary Histoplasmosis J. Immunol., June 15, 1999; 162(12): 7389 - 7396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Wu-Hsieh, W. Chen, and H.-J. Lee Nitric Oxide Synthase Expression in Macrophages of Histoplasma capsulatum-Infected Mice Is Associated with Splenocyte Apoptosis and Unresponsiveness Infect. Immun., November 1, 1998; 66(11): 5520 - 5526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Allendoerfer and G. S. Deepe Jr. Blockade of Endogenous TNF-{alpha} Exacerbates Primary and Secondary Pulmonary Histoplasmosis by Differential Mechanisms J. Immunol., June 15, 1998; 160(12): 6072 - 6082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhou and R. A. Seder CD40 Ligand Is Not Essential for Induction of Type 1 Cytokine Responses or Protective Immunity after Primary or Secondary Infection With Histoplasma capsulatum J. Exp. Med., April 20, 1998; 187(8): 1315 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Stobie, S. Gurunathan, C. Prussin, D. L. Sacks, N. Glaichenhaus, C.-Y. Wu, and R. A. Seder The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge PNAS, July 18, 2000; 97(15): 8427 - 8432. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
