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Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037
Antibody-staining experiments have shown that closely related
members of the TCRAV3 family are reciprocally selected into the CD4 or
CD8 peripheral T cell subsets. This has been attributed to the
individual AV3 members interacting preferentially with either MHC class
I or MHC class II molecules. Single amino acid residues present in the
complementarity-determining regions (CDR) CDR1
and CDR2 are
important in determining MHC class specificity. We have now extended
these observations to survey the expressed repertoire of the AV3 family
in C57BL/6 mice. Three of the four expressed AV3 members are
preferentially selected into the CD4+ subset of T
cells. These share the same amino acid residue in both CDR1 and
CDR2 that differ from the only CD8-skewed member. Preferential
expression of an individual AV3 is not caused by other endogenous -
or ß-chains, by any conserved CDR3 sequence, or by the usage of TCRAJ
regions. This study shows that residues in the CDR1 and CDR2 regions
are primary determinants for MHC class discrimination and suggests that
polymorphism found within a TCRAV family has an important effect on the
overall shaping of the T cell repertoire.
This article has been cited by other articles:
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B.-C. Sim and N. R. J. Gascoigne Reciprocal Expression in CD4 or CD8 Subsets of Different Members of the V{alpha}11 Gene Family Correlates with Sequence Polymorphism J. Immunol., March 15, 1999; 162(6): 3153 - 3159. [Abstract] [Full Text] [PDF]
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