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Departments of
*
Immunology and
Pathology, University of Manitoba, Winnipeg, Canada
The role played by NK- and NK1.1-expressing T cells in CD4 T cell
activation and induction of immune responses in vivo is controversial.
These effector cells of the innate immune response are hypothesized to
play a pivotal role in shaping initial T cell activation, with some
groups reporting that classical NK cells are required for optimal
Th1-like T cell activation, and others supporting a role for
NK1.1+ 
ß T cells in Th2 generation. Here, we
examine the impact of in vivo NK cell depletion on the development of
exogenous Ag-specific cytokine and Ab responses using a murine model of
human immediate hypersensitivity. OVA-specific immune responses were
induced in 1) C57Bl/6 bg/bg and bg/+ mice, 2)
BALB/c mice pretreated with anti-asialoGM1 or control Ab, and 3)
C57Bl/6 mice depleted of NK1.1-expressing cells by in vivo
administration of anti-NK1.1 mAb PK136. Depletion efficacy was
assessed by functional assays and flow cytometric analysis. Each of
these approaches indicated that depletion of NK cells and
NK1.1+CD4+ T cells fails to alter the Th1:Th2
balance of Ag-driven cytokine synthesis, as indicated by OVA-stimulated
cytokine synthesis in primary bulk culture. Similarly, the kinetics and
intensity of effector responses such as OVA-specific IgG2a and IgE
synthesis were neither increased nor decreased in any of the three
models examined. The results argue that NK cells and peripheral
NK1.1+ T cells do not play an essential role in shaping the
induction of Ag-specific immune responses to soluble exogenous Ags, the
most common class of inhalant allergen.
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