| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
but Requires TNF-
1
*
Interdisciplinary Graduate Program in Immunology and
Department of Microbiology, University of Iowa, Iowa City, IA 52242
CD8+ T cells are effective mediators of immunity
against Listeria monocytogenes, but the mechanisms by which
they provide antilisterial immunity are poorly understood.
CD8+ T cells efficiently lyse target cells in vitro by at
least two independent pathways. To test the hypothesis that
CD8+ T cell-mediated immunity to L.
monocytogenes is dependent on perforin or CD95 (Fas, Apo-1), we
used C57Bl/6 (B6) and perforin-deficient (PO) mice to generate
CD8+ T cell lines specific for the L.
monocytogenes-encoded Ag listeriolysin O (LLO). Both lines
specifically produce IFN-
and TNF-
, and mediate target cell lysis
in vitro. Cytolysis mediated by the PO-derived CD8+ T cell
line is delayed relative to the B6-derived line and is completely
inhibited by anti-CD95 Abs. In vivo, PO-derived CD8+ T
cells provide specific antilisterial immunity in B6 hosts,
CD95-deficient hosts, and IFN--depleted hosts. However, PO-derived
CD8+ T cells fail to provide antilisterial immunity in
hosts depleted of TNF-. These results indicate that single
Ag-specific CD8+ T cells derived from PO mice can mediate
antilisterial immunity by a mechanism that is independent of CD95 or
IFN-, but requires TNF-.
This article has been cited by other articles:
|
|
 |
|
  H. Albaghdadi, N. Robinson, B. Finlay, L. Krishnan, and S. Sad Selectively Reduced Intracellular Proliferation of Salmonella enterica Serovar Typhimurium within APCs Limits Antigen Presentation and Development of a Rapid CD8 T Cell Response J. Immunol., September 15, 2009; 183(6): 3778 - 3787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dudani, K. Murali-Krishna, L. Krishnan, and S. Sad IFN-{gamma} Induces the Erosion of Preexisting CD8 T Cell Memory during Infection with a Heterologous Intracellular Bacterium J. Immunol., August 1, 2008; 181(3): 1700 - 1709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sad, R. Dudani, K. Gurnani, M. Russell, H. van Faassen, B. Finlay, and L. Krishnan Pathogen Proliferation Governs the Magnitude but Compromises the Function of CD8 T Cells J. Immunol., May 1, 2008; 180(9): 5853 - 5861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Narni-Mancinelli, L. Campisi, D. Bassand, J. Cazareth, P. Gounon, N. Glaichenhaus, and G. Lauvau Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes J. Exp. Med., September 3, 2007; 204(9): 2075 - 2087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. N. Messingham, V. P. Badovinac, A. Jabbari, and J. T. Harty A Role for IFN-{gamma} from Antigen-Specific CD8+ T Cells in Protective Immunity to Listeria monocytogenes J. Immunol., August 15, 2007; 179(4): 2457 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Deckert, S. Virna, M. Sakowicz-Burkiewicz, S. Lutjen, S. Soltek, H. Bluethmann, and D. Schluter Interleukin-1 Receptor Type 1 Is Essential for Control of Cerebral but Not Systemic Listeriosis Am. J. Pathol., March 1, 2007; 170(3): 990 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Luu, K. Gurnani, R. Dudani, R. Kammara, H. van Faassen, J.-C. Sirard, L. Krishnan, and S. Sad Delayed Expansion and Contraction of CD8+ T Cell Response during Infection with Virulent Salmonella typhimurium J. Immunol., August 1, 2006; 177(3): 1516 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Dobbs, J. E. Strasser, C.-F. Chu, C. Chalk, and G. N. Milligan Clearance of Herpes Simplex Virus Type 2 by CD8+ T Cells Requires Gamma Interferon and either Perforin- or Fas-Mediated Cytolytic Mechanisms J. Virol., December 1, 2005; 79(23): 14546 - 14554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, M. Q. Zhao, L. Xu, C. V. Ramana, W. Declercq, P. Vandenabeele, and R. I. Enelow Requirement for Tumor Necrosis Factor-Receptor 2 in Alveolar Chemokine Expression Depends upon the Form of the Ligand Am. J. Respir. Cell Mol. Biol., November 1, 2005; 33(5): 463 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Roach, H. Briscoe, B. M. Saunders, and W. J. Britton Independent Protective Effects for Tumor Necrosis Factor and Lymphotoxin Alpha in the Host Response to Listeria monocytogenes Infection Infect. Immun., August 1, 2005; 73(8): 4787 - 4792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jiang, L. A. Zenewicz, L. R. San Mateo, L. L. Lau, and H. Shen Activation of Antigen-Specific CD8 T Cells Results in Minimal Killing of Bystander Bacteria J. Immunol., December 1, 2003; 171(11): 6032 - 6038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. N. Messingham, V. P. Badovinac, and J. T. Harty Deficient Anti-Listerial Immunity in the Absence of Perforin Can Be Restored by Increasing Memory CD8+ T Cell Numbers J. Immunol., October 15, 2003; 171(8): 4254 - 4262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Poehlein, H.-M. Hu, J. Yamada, I. Assmann, W. G. Alvord, W. J. Urba, and B. A. Fox TNF Plays an Essential Role in Tumor Regression after Adoptive Transfer of Perforin/IFN-{gamma} Double Knockout Effector T Cells J. Immunol., February 15, 2003; 170(4): 2004 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. San Mateo, M. M. Chua, S. R. Weiss, and H. Shen Perforin-Mediated CTL Cytolysis Counteracts Direct Cell-Cell Spread of Listeria monocytogenes J. Immunol., November 1, 2002; 169(9): 5202 - 5208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dudani, Y. Chapdelaine, H. van Faassen, D. K. Smith, H. Shen, L. Krishnan, and S. Sad Preexisting Inflammation Due to Mycobacterium bovis BCG Infection Differentially Modulates T-Cell Priming against a Replicating or Nonreplicating Immunogen Infect. Immun., April 1, 2002; 70(4): 1957 - 1964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rayevskaya, N. Kushnir, and F. R. Frankel Safety and Immunogenicity in Neonatal Mice of a Hyperattenuated Listeria Vaccine Directed against Human Immunodeficiency Virus J. Virol., January 15, 2002; 76(2): 918 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Tvinnereim, S. E. Hamilton, and J. T. Harty CD8+-T-Cell Response to Secreted and Nonsecreted Antigens Delivered by Recombinant Listeria monocytogenes during Secondary Infection Infect. Immun., January 1, 2002; 70(1): 153 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Hamilton, A. R. Tvinnereim, and J. T. Harty Listeria monocytogenes Infection Overcomes the Requirement for CD40 Ligand in Exogenous Antigen Presentation to CD8+ T Cells J. Immunol., November 15, 2001; 167(10): 5603 - 5609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Santori, I. Arsov, and S. Vukmanovic Modulation of CD8+ T Cell Response to Antigen by the Levels of Self MHC Class I J. Immunol., May 1, 2001; 166(9): 5416 - 5421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Walker, J. P. Olano, and H.-M. Feng Critical Role of Cytotoxic T Lymphocytes in Immune Clearance of Rickettsial Infection Infect. Immun., March 1, 2001; 69(3): 1841 - 1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Geginat, S. Schenk, M. Skoberne, W. Goebel, and H. Hof A Novel Approach of Direct Ex Vivo Epitope Mapping Identifies Dominant and Subdominant CD4 and CD8 T Cell Epitopes from Listeria monocytogenes J. Immunol., February 1, 2001; 166(3): 1877 - 1884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Zhou, B. L. Freidag, C. C. Caldwell, and R. A. Seder Perforin Is Required for Primary Immunity to Histoplasma capsulatum J. Immunol., February 1, 2001; 166(3): 1968 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Wu, A. A. Dandekar, L. Pewe, and S. Perlman CD4 and CD8 T Cells Have Redundant But Not Identical Roles in Virus-Induced Demyelination J. Immunol., August 15, 2000; 165(4): 2278 - 2286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. White, V. P. Badovinac, X. Fan, and J. T. Harty Adaptive Immunity against Listeria monocytogenes in the Absence of Type I Tumor Necrosis Factor Receptor p55 Infect. Immun., August 1, 2000; 68(8): 4470 - 4476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. White, V. P. Badovinac, G. Kollias, and J. T. Harty Cutting Edge: Antilisterial Activity of CD8+ T Cells Derived from TNF-Deficient and TNF/Perforin Double-Deficient Mice J. Immunol., July 1, 2000; 165(1): 5 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. V. Serbina, C.-C. Liu, C. A. Scanga, and J. L. Flynn CD8+ CTL from Lungs of Mycobacterium tuberculosis-Infected Mice Express Perforin In Vivo and Lyse Infected Macrophages J. Immunol., July 1, 2000; 165(1): 353 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. Badovinac and J. T. Harty Adaptive Immunity and Enhanced CD8+ T Cell Response to Listeria monocytogenes in the Absence of Perforin and IFN-{gamma} J. Immunol., June 15, 2000; 164(12): 6444 - 6452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Phan, A. W. McMahon, R. C. Nelson, J. F. Elliott, and A. G. Murray Activated Lymphocytes Promote Endothelial Cell Detachment from Matrix: A Role for Modulation of Endothelial Cell {beta}1 Integrin Affinity J. Immunol., October 15, 1999; 163(8): 4557 - 4563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. White, A. MacNeil, D. H. Busch, I. M. Pilip, E. G. Pamer, and J. T. Harty Perforin-Deficient CD8+ T Cells: In Vivo Priming and Antigen-Specific Immunity Against Listeria monocytogenes J. Immunol., January 15, 1999; 162(2): 980 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Uchijima, A. Yoshida, T. Nagata, and Y. Koide Optimization of Codon Usage of Plasmid DNA Vaccine Is Required for the Effective MHC Class I-Restricted T Cell Responses Against an Intracellular Bacterium J. Immunol., November 15, 1998; 161(10): 5594 - 5599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Jensen, A. A. Glass, W. R. Clark, E. J. Wing, J. F. Miller, and S. H. Gregory Fas (CD95)-Dependent Cell-Mediated Immunity to Listeria monocytogenes Infect. Immun., September 1, 1998; 66(9): 4143 - 4150. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
