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The Journal of Immunology, 1998, 160: 763-769.
Copyright © 1998 by The American Association of Immunologists

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death1

Lixin Zheng*, Carol L. Trageser*, Dennis M. Willerford{dagger} and Michael J. Lenardo2,*

* Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and {dagger} Department of Medicine, University of Washington and Puget Sound Blood Center, Seattle, WA 98104

TCR stimulation of T lymphocytes that are activated and cycling in the presence of IL-2 leads to programmed cell death. We now show that this effect is at least partly attributable to the ability of IL-2 to dramatically increase the expression of mRNAs encoding ligands and receptors that mediate apoptosis. We also found that cyclosporin was not able to fully inhibit the TCR induction of death molecule mRNAs or TCR-induced apoptosis, although it could completely turn off IL-2 expression. The effect of growth cytokines was further explored in T cells derived from mice bearing a homozygous deficiency of the IL-2R {alpha}-chain. We found that IL-2R{alpha}-/- cells were resistant to death if IL-2 was used to induce apoptosis susceptibility, but that large amounts of other T cell growth cytokines, such as IL-4 and IL-7, could induce cell cycle progression and promote TCR-induced apoptosis. However, our findings suggest that autoimmunity and lymphoproliferation in IL-2R{alpha}-/- mice can result from the loss of IL-2-stimulated feedback apoptosis and that other growth cytokines are not produced at levels sufficient to compensate for this deficit.




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