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Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, Université Pierre et Marie Curie, Centre National de la Recherche Scientifique (CNRS), Groupe Hospitalier Pitié-Salpêtrière, and
Genopoïétic, Paris, France
We have identified three distinct populations of mouse lymph node
dendritic cells (DC) that differ in their capacity to uptake Ag
delivered by different routes, and in their dynamics. The "l-DCs"
are large cells that resemble the interdigitating cells and have a
mature phenotype and a slow turnover. They derive from the regional
tissues. The "sm-DCs" and "sl-DCs" are smaller (hence s-DC),
have a more immature phenotype and a rapid turnover. The sl-DC
phenotype, including CD8
expression, suggests a lymphoid-related
origin. The sl-DC population is expanded 100-fold after an in vivo flt3
ligand treatment. The sm-DC phenotype suggests a myeloid-related
origin. Interestingly, sm-DCs can acquire i.v. injected macromolecules
in less than 30 min after injection. They may, therefore, play an
important role in the immune response against blood Ags.
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