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CUTTING EDGE |
Abteilung für Immunologie, Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany
T effector subsets, such as Th1 or Th2 cells, are key players in
inflammatory reactions. It is not known whether chemokines are able to
recruit these subsets differentially, as has been shown for memory vs
naive T cells. Here we demonstrate that Th1 and Th2 cells differ in
their intrinsic migratory properties and their chemotactic
responsiveness toward distinct chemokines. While the CC-chemokines
macrophage inflammatory protein (MIP)-1
, MIP-1ß, and RANTES were
efficient chemoattractants for Th1 cells, inducing a dose-dependent
transmigration, Th2 cells were not attracted by these chemokines.
Another CC-chemokine, JE/monocyte chemoattractant protein (MCP)-1, and
a CXC-chemokine, stromal cell-derived factor (SDF)-1, exerted
chemotactic effects on both Th1 and Th2 cells, but differences in
sensitivity and the percentage of responding cells were recorded
between both subsets. These results indicate that chemokines play a
distinct role in the regulation of local immune reactions by
influencing the local balance between proinflammatory and
antiinflammatory T cell subsets.
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