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The Journal of Immunology, 1998, 160: 550-554.
Copyright © 1998 by The American Association of Immunologists


CUTTING EDGE

Cutting Edge: T Helper 1 and T Helper 2 Cells Respond Differentially to Chemokines1

Jens T. Siveke and Alf Hamann2

Abteilung für Immunologie, Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany

T effector subsets, such as Th1 or Th2 cells, are key players in inflammatory reactions. It is not known whether chemokines are able to recruit these subsets differentially, as has been shown for memory vs naive T cells. Here we demonstrate that Th1 and Th2 cells differ in their intrinsic migratory properties and their chemotactic responsiveness toward distinct chemokines. While the CC-chemokines macrophage inflammatory protein (MIP)-1{alpha}, MIP-1ß, and RANTES were efficient chemoattractants for Th1 cells, inducing a dose-dependent transmigration, Th2 cells were not attracted by these chemokines. Another CC-chemokine, JE/monocyte chemoattractant protein (MCP)-1, and a CXC-chemokine, stromal cell-derived factor (SDF)-1{alpha}, exerted chemotactic effects on both Th1 and Th2 cells, but differences in sensitivity and the percentage of responding cells were recorded between both subsets. These results indicate that chemokines play a distinct role in the regulation of local immune reactions by influencing the local balance between proinflammatory and antiinflammatory T cell subsets.




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IFN-{gamma} Shapes Immune Invasion of the Central Nervous System Via Regulation of Chemokines
J. Immunol., March 1, 2000; 164(5): 2759 - 2768.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
A. Matsukawa, N. W. Lukacs, T. J. Standiford, S. W. Chensue, and S. L. Kunkel
Adenoviral-Mediated Overexpression of Monocyte Chemoattractant Protein-1 Differentially Alters the Development of Th1 and Th2 Type Responses In Vivo
J. Immunol., February 15, 2000; 164(4): 1699 - 1704.
[Abstract] [Full Text] [PDF]


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Infect. Immun.Home page
N.-H. Cho, S.-Y. Seong, M.-S. Huh, T.-H. Han, Y.-S. Koh, M.-S. Choi, and I.-S. Kim
Expression of Chemokine Genes in Murine Macrophages Infected with Orientia tsutsugamushi
Infect. Immun., February 1, 2000; 68(2): 594 - 602.
[Abstract] [Full Text] [PDF]


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Am. J. Respir. Cell Mol. Bio.Home page
M. Castro, D. D. Chaplin, M. J. Walter, and M. J. Holtzman
Could Asthma Be Worsened by Stimulating the T-helper Type 1 Immune Response?
Am. J. Respir. Cell Mol. Biol., February 1, 2000; 22(2): 143 - 146.
[Full Text]


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J. Immunol.Home page
Philip. L. Shields, C. M. Morland, M. Salmon, S. Qin, S. G. Hubscher, and D. H. Adams
Chemokine and Chemokine Receptor Interactions Provide a Mechanism for Selective T Cell Recruitment to Specific Liver Compartments Within Hepatitis C-Infected Liver
J. Immunol., December 1, 1999; 163(11): 6236 - 6243.
[Abstract] [Full Text] [PDF]


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IOVSHome page
S. Yamagami, D. Miyazaki, S. J. Ono, and M. R. Dana
Differential Chemokine Gene Expression in Corneal Transplant Rejection
Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2892 - 2897.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
S. Mukai, J. Kjargaard, S. Shu, and G. E. Plautz
Infiltration of Tumors by Systemically Transferred Tumor-Reactive T Lymphocytes Is Required for Antitumor Efficacy
Cancer Res., October 1, 1999; 59(20): 5245 - 5249.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
T. Kawai, M. Seki, K. Hiromatsu, J. W. Eastcott, G. F. M. Watts, M. Sugai, D. J. Smith, S. A. Porcelli, and M. A. Taubman
Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES
J. Immunol., September 15, 1999; 163(6): 3269 - 3278.
[Abstract] [Full Text] [PDF]


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Int ImmunolHome page
C. Abbal, P. Jourdan, T. Hori, J. Bousquet, H. Yssel, and J. Pene
TCR-mediated activation of allergen-specific CD45RO+ memory T lymphocytes results in down-regulation of cell-surface CXCR4 expression and a strongly reduced capacity to migrate in response to stromal cell-derived factor-1
Int. Immunol., September 1, 1999; 11(9): 1451 - 1462.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. W. Chensue, K. S. Warmington, E. J. Allenspach, B. Lu, C. Gerard, S. L. Kunkel, and N. W. Lukacs
Differential Expression and Cross-Regulatory Function of RANTES During Mycobacterial (Type 1) and Schistosomal (Type 2) Antigen-Elicited Granulomatous Inflammation
J. Immunol., July 1, 1999; 163(1): 165 - 173.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
J. Galon, C. Sudarshan, S. Ito, D. Finbloom, and J. J. O'Shea
IL-12 Induces IFN Regulating Factor-1 (IRF-1) Gene Expression in Human NK and T Cells
J. Immunol., June 15, 1999; 162(12): 7256 - 7262.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. K. Bliss, A. J. Marshall, Y. Zhang, and E. Y. Denkers
Human Polymorphonuclear Leukocytes Produce IL-12, TNF-{alpha}, and the Chemokines Macrophage-Inflammatory Protein-1{alpha} and -1{beta} in Response to Toxoplasma gondii Antigens
J. Immunol., June 15, 1999; 162(12): 7369 - 7375.
[Abstract] [Full Text] [PDF]


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Infect. Immun.Home page
B. Vester, K. Muller, W. Solbach, and T. Laskay
Early Gene Expression of NK Cell-Activating Chemokines in Mice Resistant to Leishmania major
Infect. Immun., June 1, 1999; 67(6): 3155 - 3159.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
M. J. Dobrzanski, J. B. Reome, and R. W. Dutton
Therapeutic Effects of Tumor-Reactive Type 1 and Type 2 CD8+ T Cell Subpopulations in Established Pulmonary Metastases
J. Immunol., June 1, 1999; 162(11): 6671 - 6680.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. Sur, J. S. Wild, B. K. Choudhury, N. Sur, R. Alam, and D. M. Klinman
Long Term Prevention of Allergic Lung Inflammation in a Mouse Model of Asthma by CpG Oligodeoxynucleotides
J. Immunol., May 15, 1999; 162(10): 6284 - 6293.
[Abstract] [Full Text] [PDF]


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Am. J. Respir. Cell Mol. Bio.Home page
S. L. Kunkel
Promiscuous Chemokine Receptors and Their Redundant Ligands Play an Enigmatic Role during HIV-1 Infection
Am. J. Respir. Cell Mol. Biol., May 1, 1999; 20(5): 859 - 860.
[Full Text]


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Am. J. Pathol.Home page
K. S. Warmington, L. Boring, J. H. Ruth, J. Sonstein, C. M. Hogaboam, J. L. Curtis, S. L. Kunkel, I. R. Charo, and S. W. Chensue
Effect of C-C Chemokine Receptor 2 (CCR2) Knockout on Type-2 (Schistosomal Antigen-Elicited) Pulmonary Granuloma Formation : Analysis of Cellular Recruitment and Cytokine Responses
Am. J. Pathol., May 1, 1999; 154(5): 1407 - 1416.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
H. A. Doyle and J. W. Murphy
Role of the C-C Chemokine, TCA3, in the Protective Anticryptococcal Cell-Mediated Immune Response
J. Immunol., April 15, 1999; 162(8): 4824 - 4833.
[Abstract] [Full Text] [PDF]


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Int ImmunolHome page
N. Suzuki, A. Nakajima, S. Yoshino, K. Matsushima, H. Yagita, and K. Okumura
Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritis
Int. Immunol., April 1, 1999; 11(4): 553 - 559.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
R. L. Rabin, M. K. Park, F. Liao, R. Swofford, D. Stephany, and J. M. Farber
Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling
J. Immunol., April 1, 1999; 162(7): 3840 - 3850.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
L. M. Bradley, V. C. Asensio, L.-K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick
Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes
J. Immunol., March 1, 1999; 162(5): 2511 - 2520.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
F. Liao, R. L. Rabin, C. S. Smith, G. Sharma, T. B. Nutman, and J. M. Farber
CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3{alpha}
J. Immunol., January 1, 1999; 162(1): 186 - 194.
[Abstract] [Full Text] [PDF]


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JEMHome page
A. J. Wagers, C. M. Waters, L. M. Stoolman, and G. S. Kansas
Interleukin 12 and Interleukin 4 Control T Cell Adhesion to Endothelial Selectins through Opposite Effects on {alpha}1,3-fucosyltransferase VII Gene Expression
J. Exp. Med., December 21, 1998; 188(12): 2225 - 2231.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
A. Zingoni, H. Soto, J. A. Hedrick, A. Stoppacciaro, C. T. Storlazzi, F. Sinigaglia, D. D'Ambrosio, A. O'Garra, D. Robinson, M. Rocchi, et al.
Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells
J. Immunol., July 15, 1998; 161(2): 547 - 551.
[Abstract] [Full Text] [PDF]


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JEMHome page
M. Taguchi, D. Sampath, T. Koga, M. Castro, D. C. Look, S. Nakajima, and M. J. Holtzman
Patterns for RANTES Secretion and Intercellular Adhesion Molecule 1 Expression Mediate Transepithelial T Cell Traffic Based on Analyses In Vitro and In Vivo
J. Exp. Med., June 15, 1998; 187(12): 1927 - 1940.
[Abstract] [Full Text] [PDF]




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