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CUTTING EDGE |
Abteilung für Immunologie, Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany
T effector subsets, such as Th1 or Th2 cells, are key players in
inflammatory reactions. It is not known whether chemokines are able to
recruit these subsets differentially, as has been shown for memory vs
naive T cells. Here we demonstrate that Th1 and Th2 cells differ in
their intrinsic migratory properties and their chemotactic
responsiveness toward distinct chemokines. While the CC-chemokines
macrophage inflammatory protein (MIP)-1
, MIP-1ß, and RANTES were
efficient chemoattractants for Th1 cells, inducing a dose-dependent
transmigration, Th2 cells were not attracted by these chemokines.
Another CC-chemokine, JE/monocyte chemoattractant protein (MCP)-1, and
a CXC-chemokine, stromal cell-derived factor (SDF)-1, exerted
chemotactic effects on both Th1 and Th2 cells, but differences in
sensitivity and the percentage of responding cells were recorded
between both subsets. These results indicate that chemokines play a
distinct role in the regulation of local immune reactions by
influencing the local balance between proinflammatory and
antiinflammatory T cell subsets.
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Philip. L. Shields, C. M. Morland, M. Salmon, S. Qin, S. G. Hubscher, and D. H. Adams Chemokine and Chemokine Receptor Interactions Provide a Mechanism for Selective T Cell Recruitment to Specific Liver Compartments Within Hepatitis C-Infected Liver J. Immunol., December 1, 1999; 163(11): 6236 - 6243. [Abstract] [Full Text] [PDF]
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S. Yamagami, D. Miyazaki, S. J. Ono, and M. R. Dana Differential Chemokine Gene Expression in Corneal Transplant Rejection Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2892 - 2897. [Abstract] [Full Text] [PDF]
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S. Mukai, J. Kjargaard, S. Shu, and G. E. Plautz Infiltration of Tumors by Systemically Transferred Tumor-Reactive T Lymphocytes Is Required for Antitumor Efficacy Cancer Res., October 1, 1999; 59(20): 5245 - 5249. [Abstract] [Full Text] [PDF]
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T. Kawai, M. Seki, K. Hiromatsu, J. W. Eastcott, G. F. M. Watts, M. Sugai, D. J. Smith, S. A. Porcelli, and M. A. Taubman Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES J. Immunol., September 15, 1999; 163(6): 3269 - 3278. [Abstract] [Full Text] [PDF]
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C. Abbal, P. Jourdan, T. Hori, J. Bousquet, H. Yssel, and J. Pene TCR-mediated activation of allergen-specific CD45RO+ memory T lymphocytes results in down-regulation of cell-surface CXCR4 expression and a strongly reduced capacity to migrate in response to stromal cell-derived factor-1 Int. Immunol., September 1, 1999; 11(9): 1451 - 1462. [Abstract] [Full Text] [PDF]
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S. W. Chensue, K. S. Warmington, E. J. Allenspach, B. Lu, C. Gerard, S. L. Kunkel, and N. W. Lukacs Differential Expression and Cross-Regulatory Function of RANTES During Mycobacterial (Type 1) and Schistosomal (Type 2) Antigen-Elicited Granulomatous Inflammation J. Immunol., July 1, 1999; 163(1): 165 - 173. [Abstract] [Full Text] [PDF]
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J. Galon, C. Sudarshan, S. Ito, D. Finbloom, and J. J. O'Shea IL-12 Induces IFN Regulating Factor-1 (IRF-1) Gene Expression in Human NK and T Cells J. Immunol., June 15, 1999; 162(12): 7256 - 7262. [Abstract] [Full Text] [PDF]
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S. K. Bliss, A. J. Marshall, Y. Zhang, and E. Y. Denkers Human Polymorphonuclear Leukocytes Produce IL-12, TNF-{alpha}, and the Chemokines Macrophage-Inflammatory Protein-1{alpha} and -1{beta} in Response to Toxoplasma gondii Antigens J. Immunol., June 15, 1999; 162(12): 7369 - 7375. [Abstract] [Full Text] [PDF]
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B. Vester, K. Muller, W. Solbach, and T. Laskay Early Gene Expression of NK Cell-Activating Chemokines in Mice Resistant to Leishmania major Infect. Immun., June 1, 1999; 67(6): 3155 - 3159. [Abstract] [Full Text] [PDF]
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M. J. Dobrzanski, J. B. Reome, and R. W. Dutton Therapeutic Effects of Tumor-Reactive Type 1 and Type 2 CD8+ T Cell Subpopulations in Established Pulmonary Metastases J. Immunol., June 1, 1999; 162(11): 6671 - 6680. [Abstract] [Full Text] [PDF]
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S. Sur, J. S. Wild, B. K. Choudhury, N. Sur, R. Alam, and D. M. Klinman Long Term Prevention of Allergic Lung Inflammation in a Mouse Model of Asthma by CpG Oligodeoxynucleotides J. Immunol., May 15, 1999; 162(10): 6284 - 6293. [Abstract] [Full Text] [PDF]
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S. L. Kunkel Promiscuous Chemokine Receptors and Their Redundant Ligands Play an Enigmatic Role during HIV-1 Infection Am. J. Respir. Cell Mol. Biol., May 1, 1999; 20(5): 859 - 860. [Full Text]
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K. S. Warmington, L. Boring, J. H. Ruth, J. Sonstein, C. M. Hogaboam, J. L. Curtis, S. L. Kunkel, I. R. Charo, and S. W. Chensue Effect of C-C Chemokine Receptor 2 (CCR2) Knockout on Type-2 (Schistosomal Antigen-Elicited) Pulmonary Granuloma Formation : Analysis of Cellular Recruitment and Cytokine Responses Am. J. Pathol., May 1, 1999; 154(5): 1407 - 1416. [Abstract] [Full Text] [PDF]
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H. A. Doyle and J. W. Murphy Role of the C-C Chemokine, TCA3, in the Protective Anticryptococcal Cell-Mediated Immune Response J. Immunol., April 15, 1999; 162(8): 4824 - 4833. [Abstract] [Full Text] [PDF]
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N. Suzuki, A. Nakajima, S. Yoshino, K. Matsushima, H. Yagita, and K. Okumura Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritis Int. Immunol., April 1, 1999; 11(4): 553 - 559. [Abstract] [Full Text] [PDF]
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R. L. Rabin, M. K. Park, F. Liao, R. Swofford, D. Stephany, and J. M. Farber Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling J. Immunol., April 1, 1999; 162(7): 3840 - 3850. [Abstract] [Full Text] [PDF]
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L. M. Bradley, V. C. Asensio, L.-K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes J. Immunol., March 1, 1999; 162(5): 2511 - 2520. [Abstract] [Full Text] [PDF]
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F. Liao, R. L. Rabin, C. S. Smith, G. Sharma, T. B. Nutman, and J. M. Farber CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3{alpha} J. Immunol., January 1, 1999; 162(1): 186 - 194. [Abstract] [Full Text] [PDF]
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A. J. Wagers, C. M. Waters, L. M. Stoolman, and G. S. Kansas Interleukin 12 and Interleukin 4 Control T Cell Adhesion to Endothelial Selectins through Opposite Effects on {alpha}1,3-fucosyltransferase VII Gene Expression J. Exp. Med., December 21, 1998; 188(12): 2225 - 2231. [Abstract] [Full Text] [PDF]
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A. Zingoni, H. Soto, J. A. Hedrick, A. Stoppacciaro, C. T. Storlazzi, F. Sinigaglia, D. D'Ambrosio, A. O'Garra, D. Robinson, M. Rocchi, et al. Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells J. Immunol., July 15, 1998; 161(2): 547 - 551. [Abstract] [Full Text] [PDF]
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M. Taguchi, D. Sampath, T. Koga, M. Castro, D. C. Look, S. Nakajima, and M. J. Holtzman Patterns for RANTES Secretion and Intercellular Adhesion Molecule 1 Expression Mediate Transepithelial T Cell Traffic Based on Analyses In Vitro and In Vivo J. Exp. Med., June 15, 1998; 187(12): 1927 - 1940. [Abstract] [Full Text] [PDF]
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