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The Journal of Immunology, 1998, 160: 535-539.
Copyright © 1998 by The American Association of Immunologists

Cutting Edge Commentary: Differential TCR Signaling and the Generation of Memory T Cells

Donna L. Farber

Department of Microbiology, University of Maryland, College Park, MD 20742

There are currently two models for the generation of memory T cells: 1) memory T cells arise directly from activated effector T cells that have reverted to the resting state via an unknown mechanism; and 2) memory T cells are generated directly from naive T cells, bypassing an effector stage. I discuss here how recent results on the activation and signaling requirements of naive vs memory CD4 T cells favor the second model and how differential signaling of naive T cells may direct their developmental outcome.




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