HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Steinhoff, U. Articles by Kaufmann, S. H. E. Search for Related Content PubMed PubMed Citation Articles by Steinhoff, U. Articles by Kaufmann, S. H. E.

Altered Intestinal Immune System but Normal Antibacterial Resistance in the Absence of P-Selectin and ICAM-1

Department of Immunology, Max Planck Institute of Infection Biology, Berlin, Germany

ICAM-1 and P-selectin are adhesion molecules that regulate leukocyte migration, extravasation to inflammatory sites, and other immune cell interactions. T cell-mediated resistance against acute infection with Listeria monocytogenes and chronic infection with Mycobacterium bovis Calmette-Guérin bacillus was investigated in mutant mice lacking P-selectin and/or ICAM-1. Mice deficient in P-selectin (Psel^-/-), ICAM-1 (ICAM^-/-), or the combination of both (Psel^-/- x ICAM^-/-) showed normal bacterial clearance, comparable delayed-type hypersensitivity reactions, and equivalent memory T cell responses. Additionally, the distribution of ß vs T lymphocyte populations was examined. Normal lymphocyte distributions were noted in thymus, spleen, and blood, whereas mutant mice showed marked alterations in the intestinal intraepithelial (i-IEL) and lamina propria lymphocytes. Differences in i-IEL populations were reflected functionally by differential lytic activities and cytokine productions of i-IEL populations from mutant mice. Despite these changes within the mucosal immune system of mutant mice, their resistance against oral infection with L. monocytogenes was apparently unimpaired. These findings demonstrate that P-selectin and ICAM-1 are critically involved in the shaping of lymphocyte populations of the gut but have only a minor influence on systemic and regional host defense against intracellular bacteria.

This article has been cited by other articles:

				K. Koskinen, S. Nevalainen, M. Karikoski, A. Hanninen, S. Jalkanen, and M. Salmi VAP-1-Deficient Mice Display Defects in Mucosal Immunity and Antimicrobial Responses: Implications for Antiadhesive Applications J. Immunol., November 1, 2007; 179(9): 6160 - 6168. [Abstract] [Full Text] [PDF]

				T. Schreiber, S. Ehlers, S. Aly, A. Holscher, S. Hartmann, M. Lipp, J. B. Lowe, and C. Holscher Selectin Ligand-Independent Priming and Maintenance of T Cell Immunity during Airborne Tuberculosis J. Immunol., January 15, 2006; 176(2): 1131 - 1140. [Abstract] [Full Text] [PDF]

				H. Wu, J. E. Prince, C. F. Brayton, C. Shah, D. Zeve, S. H. Gregory, C. W. Smith, and C. M. Ballantyne Host Resistance of CD18 Knockout Mice against Systemic Infection with Listeria monocytogenes Infect. Immun., October 1, 2003; 71(10): 5986 - 5993. [Abstract] [Full Text] [PDF]

				E. Wilson, M. K. Aydintug, and M. A. Jutila A Circulating Bovine {gamma}{delta} T Cell Subset, Which Is Found in Large Numbers in the Spleen, Accumulates Inefficiently in an Artificial Site of Inflammation: Correlation with Lack of Expression of E-Selectin Ligands and L-Selectin J. Immunol., April 15, 1999; 162(8): 4914 - 4919. [Abstract] [Full Text] [PDF]