| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Wisconsin Regional Primate Research Center and
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53715;
Eppimune, San Diego, CA 92121;
§
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772; and
¶
Infectious Disease Unit and Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA 02129;
||
Laboratory of Genetics, University of Wisconsin, Madison, WI 53706
The majority of immunogenic CTL epitopes bind to MHC class I molecules with high affinity. However, peptides longer or shorter than the optimal epitope rarely bind with high affinity. Therefore, identification of optimal CTL epitopes from pathogens may ultimately be critical for inducing strong CTL responses and developing epitope-based vaccines. The SIV-infected rhesus macaque is an excellent animal model for HIV infection of humans. Although a number of CTL epitopes have been mapped in SIV-infected rhesus macaques, the optimal epitopes have not been well defined, and their anchor residues are unknown. We have now defined the optimal SIV gag CTL epitope restricted by the rhesus MHC class I molecule Mamu-A*01 and defined a general peptide binding motif for this molecule that is characterized by a dominant position 3 anchor (proline). We used peptide elution and sequencing, peptide binding assays, and bulk and clonal CTL assays to demonstrate that the optimal Mamu-A*01-restricted SIV gag CTL epitope was CTPYDINQM181–189. Mamu-A*01 is unique in that it is found at a high frequency in rhesus macaques, and all SIV-infected Mamu-A*01-positive rhesus macaques studied to date develop an immunodominant gag-specific CTL response restricted by this molecule. Identification of the optimal SIV gag CTL epitope will be critical for a variety of studies designed to induce CD8+ CTL responses specific for SIV in the rhesus macaque.
This article has been cited by other articles:
|
|
 |
|
  M. Genesca, P. J. Skinner, J. J. Hong, J. Li, D. Lu, M. B. McChesney, and C. J. Miller With Minimal Systemic T-Cell Expansion, CD8+ T Cells Mediate Protection of Rhesus Macaques Immunized with Attenuated Simian-Human Immunodeficiency Virus SHIV89.6 from Vaginal Challenge with Simian Immunodeficiency Virus J. Virol., November 15, 2008; 82(22): 11181 - 11196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Reynolds, A. M. Weiler, K. L. Weisgrau, S. M. Piaskowski, J. R. Furlott, J. T. Weinfurter, M. Kaizu, T. Soma, E. J. Leon, C. MacNair, et al. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus J. Exp. Med., October 27, 2008; 205(11): 2537 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Kaufman, J. Liu, A. Carville, K. G. Mansfield, M. J. E. Havenga, J. Goudsmit, and D. H. Barouch Trafficking of Antigen-Specific CD8+ T Lymphocytes to Mucosal Surfaces following Intramuscular Vaccination J. Immunol., September 15, 2008; 181(6): 4188 - 4198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-Y. Kim, R. S. Veazey, R. Zahn, K. J. McEvers, S. H. C. Baumeister, G. J. Foster, M. D. Rett, M. H. Newberg, M. J. Kuroda, E. P. Rieber, et al. Contribution of CD8+ T Cells to Containment of Viral Replication and Emergence of Mutations in Mamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys J. Virol., June 1, 2008; 82(11): 5631 - 5635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Loffredo, A. T. Bean, D. R. Beal, E. J. Leon, G. E. May, S. M. Piaskowski, J. R. Furlott, J. Reed, S. K. Musani, E. G. Rakasz, et al. Patterns of CD8+ Immunodominance May Influence the Ability of Mamu-B*08-Positive Macaques To Naturally Control Simian Immunodeficiency Virus SIVmac239 Replication J. Virol., February 15, 2008; 82(4): 1723 - 1738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sen, W. A. Charini, R. A. Subbramanian, E. R. Manuel, M. J. Kuroda, P. A. Autissier, and N. L. Letvin Clonal Focusing of Epitope-Specific CD8+ T Lymphocytes in Rhesus Monkeys following Vaccination and Simian-Human Immunodeficiency Virus Challenge J. Virol., January 15, 2008; 82(2): 805 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Mueller, D. H. Do, S. R. Altork, C. M. Artlett, E. J. Gracely, C. D. Katsetos, A. Legido, F. Villinger, J. D. Altman, C. R. Brown, et al. IL-15 Treatment during Acute Simian Immunodeficiency Virus (SIV) Infection Increases Viral Set Point and Accelerates Disease Progression despite the Induction of Stronger SIV-Specific CD8+ T Cell Responses J. Immunol., January 1, 2008; 180(1): 350 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Mandl, R. R. Regoes, D. A. Garber, and M. B. Feinberg Estimating the Effectiveness of Simian Immunodeficiency Virus-Specific CD8+ T Cells from the Dynamics of Viral Immune Escape J. Virol., November 1, 2007; 81(21): 11982 - 11991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Mueller, C. Petrovas, D. H. Do, S. R. Altork, T. Fischer-Smith, J. Rappaport, J. D. Altman, M. G. Lewis, and P. D. Katsikis Early Establishment and Antigen Dependence of Simian Immunodeficiency Virus-Specific CD8+ T-Cell Defects J. Virol., October 15, 2007; 81(20): 10861 - 10868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Miller, M. Genesca, K. Abel, D. Montefiori, D. Forthal, K. Bost, J. Li, D. Favre, and J. M. McCune Antiviral Antibodies Are Necessary for Control of Simian Immunodeficiency Virus Replication J. Virol., May 15, 2007; 81(10): 5024 - 5035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Chu, Z. Lou, Y. W. Chen, Y. Liu, B. Gao, L. Zong, A. H. Khan, J. I. Bell, Z. Rao, and G. F. Gao First Glimpse of the Peptide Presentation by Rhesus Macaque MHC Class I: Crystal Structures of Mamu-A*01 Complexed with Two Immunogenic SIV Epitopes and Insights into CTL Escape J. Immunol., January 15, 2007; 178(2): 944 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Manuel, W. A. Charini, P. Sen, F. W. Peyerl, M. J. Kuroda, J. E. Schmitz, P. Autissier, D. A. Sheeter, B. E. Torbett, and N. L. Letvin Contribution of T-Cell Receptor Repertoire Breadth to the Dominance of Epitope-Specific CD8+ T-Lymphocyte Responses J. Virol., December 15, 2006; 80(24): 12032 - 12040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Belyakov, V. A. Kuznetsov, B. Kelsall, D. Klinman, M. Moniuszko, M. Lemon, P. D. Markham, R. Pal, J. D. Clements, M. G. Lewis, et al. Impact of vaccine-induced mucosal high-avidity CD8+CTLs in delay of AIDS viral dissemination from mucosa Blood, April 15, 2006; 107(8): 3258 - 3264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Newberg, K. J. McEvers, D. A. Gorgone, M. A. Lifton, S. H. C. Baumeister, R. S. Veazey, J. E. Schmitz, and N. L. Letvin Immunodomination in the Evolution of Dominant Epitope-Specific CD8+ T Lymphocyte Responses in Simian Immunodeficiency Virus-Infected Rhesus Monkeys J. Immunol., January 1, 2006; 176(1): 319 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. McDermott, D. H. O'Connor, S. Fuenger, S. Piaskowski, S. Martin, J. Loffredo, M. Reynolds, J. Reed, J. Furlott, T. Jacoby, et al. Cytotoxic T-Lymphocyte Escape Does Not Always Explain the Transient Control of Simian Immunodeficiency Virus SIVmac239 Viremia in Adenovirus-Boosted and DNA-Primed Mamu-A*01-Positive Rhesus Macaques J. Virol., December 15, 2005; 79(24): 15556 - 15566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Loffredo, J. Sidney, S. Piaskowski, A. Szymanski, J. Furlott, R. Rudersdorf, J. Reed, B. Peters, H. D. Hickman-Miller, W. Bardet, et al. The High Frequency Indian Rhesus Macaque MHC Class I Molecule, Mamu-B*01, Does Not Appear to Be Involved in CD8+ T Lymphocyte Responses to SIVmac239 J. Immunol., November 1, 2005; 175(9): 5986 - 5997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Hickman-Miller, W. Bardet, A. Gilb, A. D. Luis, K. W. Jackson, D. I. Watkins, and W. H. Hildebrand Rhesus Macaque MHC Class I Molecules Present HLA-B-Like Peptides J. Immunol., July 1, 2005; 175(1): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Evans, J. E. Bricker, H. B. Sanford, S. Lang, A. Carville, B. A. Richardson, M. Piatak Jr., J. D. Lifson, K. G. Mansfield, and R. C. Desrosiers Immunization of Macaques with Single-Cycle Simian Immunodeficiency Virus (SIV) Stimulates Diverse Virus-Specific Immune Responses and Reduces Viral Loads after Challenge with SIVmac239 J. Virol., June 15, 2005; 79(12): 7707 - 7720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Su, M. A. Luscher, Y. Xiong, T. Rustam, R. R. Amara, E. Rakasz, H. L. Robinson, and K. S. MacDonald Novel simian immunodeficiency virus CTL epitopes restricted by MHC class I molecule Mamu-B*01 are highly conserved for long term in DNA/MVA-vaccinated, SHIV-challenged rhesus macaques Int. Immunol., May 1, 2005; 17(5): 637 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nacsa, Y. Edghill-Smith, W.-P. Tsai, D. Venzon, E. Tryniszewska, A. Hryniewicz, M. Moniuszko, A. Kinter, K. A. Smith, and G. Franchini Contrasting Effects of Low-Dose IL-2 on Vaccine-Boosted Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cells in Macaques Chronically Infected with SIVmac251 J. Immunol., February 15, 2005; 174(4): 1913 - 1921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Otting, C. M. C. Heijmans, R. C. Noort, N. G. de Groot, G. G. M. Doxiadis, J. J. van Rood, D. I. Watkins, and R. E. Bontrop Unparalleled complexity of the MHC class I region in rhesus macaques PNAS, February 1, 2005; 102(5): 1626 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Z. Smith, C. J. Dale, R. De Rose, I. Stratov, C. S. Fernandez, A. G. Brooks, J. Weinfurter, K. Krebs, C. Riek, D. I. Watkins, et al. Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes J. Virol., January 15, 2005; 79(2): 684 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Loffredo, J. Sidney, C. Wojewoda, E. Dodds, M. R. Reynolds, G. Napoe, B. R. Mothe, D. H. O'Connor, N. A. Wilson, D. I. Watkins, et al. Identification of Seventeen New Simian Immunodeficiency Virus-Derived CD8+ T Cell Epitopes Restricted by the High Frequency Molecule, Mamu-A*02, and Potential Escape from CTL Recognition J. Immunol., October 15, 2004; 173(8): 5064 - 5076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Sharpe, A. Cope, S. Dowall, N. Berry, C. Ham, J. L. Heeney, D. Hopkins, L. Easterbrook, M. Dennis, N. Almond, et al. Macaques infected long-term with attenuated simian immunodeficiency virus (SIVmac) remain resistant to wild-type challenge, despite declining cytotoxic T lymphocyte responses to an immunodominant epitope J. Gen. Virol., September 1, 2004; 85(9): 2591 - 2602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Izumi, Y. Ami, K. Matsuo, K. Someya, T. Sata, N. Yamamoto, and M. Honda Intravenous Inoculation of Replication-Deficient Recombinant Vaccinia Virus DIs Expressing Simian Immunodeficiency Virus Gag Controls Highly Pathogenic Simian-Human Immunodeficiency Virus in Monkeys J. Virol., December 15, 2003; 77(24): 13248 - 13256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. U. Vogel, M. R. Reynolds, D. H. Fuller, K. Vielhuber, T. Shipley, J. T. Fuller, K. J. Kunstman, G. Sutter, M. L. Marthas, V. Erfle, et al. Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239 J. Virol., December 15, 2003; 77(24): 13348 - 13360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sidney, S. Southwood, V. Pasquetto, and A. Sette Simultaneous Prediction of Binding Capacity for Multiple Molecules of the HLA B44 Supertype J. Immunol., December 1, 2003; 171(11): 5964 - 5974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. O'Connor, B. R. Mothe, J. T. Weinfurter, S. Fuenger, W. M. Rehrauer, P. Jing, R. R. Rudersdorf, M. E. Liebl, K. Krebs, J. Vasquez, et al. Major Histocompatibility Complex Class I Alleles Associated with Slow Simian Immunodeficiency Virus Disease Progression Bind Epitopes Recognized by Dominant Acute-Phase Cytotoxic-T-Lymphocyte Responses J. Virol., August 15, 2003; 77(16): 9029 - 9040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. McGuire, S. R. Leib, R. H. Mealey, D. G. Fraser, and D. J. Prieur Presentation and Binding Affinity of Equine Infectious Anemia Virus CTL Envelope and Matrix Protein Epitopes by an Expressed Equine Classical MHC Class I Molecule J. Immunol., August 15, 2003; 171(4): 1984 - 1993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. P. Lafont, A. Buckler-White, R. Plishka, C. Buckler, and M. A. Martin Characterization of Pig-Tailed Macaque Classical MHC Class I Genes: Implications for MHC Evolution and Antigen Presentation in Macaques J. Immunol., July 15, 2003; 171(2): 875 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Barouch, J. Kunstman, J. Glowczwskie, K. J. Kunstman, M. A. Egan, F. W. Peyerl, S. Santra, M. J. Kuroda, J. E. Schmitz, K. Beaudry, et al. Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys J. Virol., July 1, 2003; 77(13): 7367 - 7375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Malkevitch, L. J. Patterson, K. Aldrich, E. Richardson, W. G. Alvord, and M. Robert-Guroff A Replication Competent Adenovirus 5 Host Range Mutant-Simian Immunodeficiency Virus (SIV) Recombinant Priming/Subunit Protein Boosting Vaccine Regimen Induces Broad, Persistent SIV-Specific Cellular Immunity to Dominant and Subdominant Epitopes in Mamu-A*01 Rhesus Macaques J. Immunol., April 15, 2003; 170(8): 4281 - 4289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Evans, L.-M. Chen, J. Gillis, K.-C. Lin, B. Harty, G. P. Mazzara, R. O. Donis, K. G. Mansfield, J. D. Lifson, R. C. Desrosiers, et al. Mucosal Priming of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses in Rhesus Macaques by the Salmonella Type III Secretion Antigen Delivery System J. Virol., February 15, 2003; 77(4): 2400 - 2409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Mothe, J. Weinfurter, C. Wang, W. Rehrauer, N. Wilson, T. M. Allen, D. B. Allison, and D. I. Watkins Expression of the Major Histocompatibility Complex Class I Molecule Mamu-A*01 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication J. Virol., February 15, 2003; 77(4): 2736 - 2740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tryniszewska, J. Nacsa, M. G. Lewis, P. Silvera, D. Montefiori, D. Venzon, Z. Hel, R. W. Parks, M. Moniuszko, J. Tartaglia, et al. Vaccination of Macaques with Long-Standing SIVmac251 Infection Lowers the Viral Set Point After Cessation of Antiretroviral Therapy J. Immunol., November 1, 2002; 169(9): 5347 - 5357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. U. Vogel, H. Horton, D. H. Fuller, D. K. Carter, K. Vielhuber, D. H. O'Connor, T. Shipley, J. Fuller, G. Sutter, V. Erfle, et al. Differences Between T Cell Epitopes Recognized After Immunization and After Infection J. Immunol., October 15, 2002; 169(8): 4511 - 4521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Baig, D. B. Levy, P. F. McKay, J. E. Schmitz, S. Santra, R. A. Subbramanian, M. J. Kuroda, M. A. Lifton, D. A. Gorgone, L. S. Wyatt, et al. Elicitation of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Mucosal Compartments of Rhesus Monkeys by Systemic Vaccination J. Virol., October 11, 2002; 76(22): 11484 - 11490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. U. Vogel, T. C. Friedrich, D. H. O'Connor, W. Rehrauer, E. J. Dodds, H. Hickman, W. Hildebrand, J. Sidney, A. Sette, A. Hughes, et al. Escape in One of Two Cytotoxic T-Lymphocyte Epitopes Bound by a High-Frequency Major Histocompatibility Complex Class I Molecule, Mamu-A*02: a Paradigm for Virus Evolution and Persistence? J. Virol., October 11, 2002; 76(22): 11623 - 11636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Allen, P. Jing, B. Calore, H. Horton, D. H. O'Connor, T. Hanke, M. Piekarczyk, R. Ruddersdorf, B. R. Mothe, C. Emerson, et al. Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection J. Virol., September 11, 2002; 76(20): 10507 - 10511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Mothe, J. Sidney, J. L. Dzuris, M. E. Liebl, S. Fuenger, D. I. Watkins, and A. Sette Characterization of the Peptide-Binding Specificity of Mamu-B*17 and Identification of Mamu-B*17-Restricted Epitopes Derived from Simian Immunodeficiency Virus Proteins J. Immunol., July 1, 2002; 169(1): 210 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Horton, T. U. Vogel, D. K. Carter, K. Vielhuber, D. H. Fuller, T. Shipley, J. T. Fuller, K. J. Kunstman, G. Sutter, D. C. Montefiori, et al. Immunization of Rhesus Macaques with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen Induces Broad Simian Immunodeficiency Virus (SIV)-Specific T-Cell Responses and Reduces Initial Viral Replication but Does Not Prevent Disease Progression following Challenge with Pathogenic SIVmac239 J. Virol., June 14, 2002; 76(14): 7187 - 7202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Santra, D. H. Barouch, M. J. Kuroda, J. E. Schmitz, G. R. Krivulka, K. Beaudry, C. I. Lord, M. A. Lifton, L. S. Wyatt, B. Moss, et al. Prior Vaccination Increases the Epitopic Breadth of the Cytotoxic T-Lymphocyte Response That Evolves in Rhesus Monkeys following a Simian-Human Immunodeficiency Virus Infection J. Virol., May 13, 2002; 76(12): 6376 - 6381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Santra, J. E. Schmitz, M. J. Kuroda, M. A. Lifton, C. E. Nickerson, C. I. Lord, R. Pal, G. Franchini, and N. L. Letvin Recombinant Canarypox Vaccine-Elicited CTL Specific for Dominant and Subdominant Simian Immunodeficiency Virus Epitopes in Rhesus Monkeys J. Immunol., February 15, 2002; 168(4): 1847 - 1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G.-T. Wee, S. Patel, A. J. McMichael, and T. Hanke A DNA/MVA-based candidate human immunodeficiency virus vaccine for Kenya induces multi-specific T cell responses in rhesus macaques J. Gen. Virol., January 1, 2002; 83(1): 75 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. U. Vogel, B. E. Beer, J. zur Megede, H.-G. Ihlenfeldt, G. Jung, S. Holzammer, D. I. Watkins, J. D. Altman, R. Kurth, and S. Norley Induction of anti-simian immunodeficiency virus cellular and humoral immune responses in rhesus macaques by peptide immunogens: correlation of CTL activity and reduction of cell-associated but not plasma virus load following challenge J. Gen. Virol., January 1, 2002; 83(1): 81 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Hel, W.-P. Tsai, A. Thornton, J. Nacsa, L. Giuliani, E. Tryniszewska, M. Poudyal, D. Venzon, X. Wang, J. Altman, et al. Potentiation of Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cell Responses by a DNA-SIV and NYVAC-SIV Prime/Boost Regimen J. Immunol., December 15, 2001; 167(12): 7180 - 7191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Dzuris, J. Sidney, H. Horton, R. Correa, D. Carter, R. W. Chesnut, D. I. Watkins, and A. Sette Molecular Determinants of Peptide Binding to Two Common Rhesus Macaque Major Histocompatibility Complex Class II Molecules J. Virol., November 15, 2001; 75(22): 10958 - 10968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Robinson, W. A. Charini, M. H. Newberg, M. J. Kuroda, C. I. Lord, and N. L. Letvin A Commonly Recognized Simian Immunodeficiency Virus Nef Epitope Presented to Cytotoxic T Lymphocytes of Indian-Origin Rhesus Monkeys by the Prevalent Major Histocompatibility Complex Class I Allele Mamu-A*02 J. Virol., November 1, 2001; 75(21): 10179 - 10186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Charini, M. J. Kuroda, J. E. Schmitz, K. R. Beaudry, W. Lin, M. A. Lifton, G. R. Krivulka, A. Necker, and N. L. Letvin Clonally Diverse CTL Response to a Dominant Viral Epitope Recognizes Potential Epitope Variants J. Immunol., November 1, 2001; 167(9): 4996 - 5003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sharpe, N. Polyanskaya, M. Dennis, G. Sutter, T. Hanke, V. Erfle, V. Hirsch, and M. Cranage Induction of simian immunodeficiency virus (SIV)-specific CTL in rhesus macaques by vaccination with modified vaccinia virus Ankara expressing SIV transgenes: influence of pre-existing anti-vector immunity J. Gen. Virol., September 1, 2001; 82(9): 2215 - 2223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Barouch, S. Santra, M. J. Kuroda, J. E. Schmitz, R. Plishka, A. Buckler-White, A. E. Gaitan, R. Zin, J.-H. Nam, L. S. Wyatt, et al. Reduction of Simian-Human Immunodeficiency Virus 89.6P Viremia in Rhesus Monkeys by Recombinant Modified Vaccinia Virus Ankara Vaccination J. Virol., June 1, 2001; 75(11): 5151 - 5158. [Abstract] [Full Text]
|
|
|
|
|
|
M. Rosenzweig, M. Connole, R. Glickman, S.-P. S. Yue, B. Noren, M. DeMaria, and R. P. Johnson Induction of cytotoxic T lymphocyte and antibody responses to enhanced green fluorescent protein following transplantation of transduced CD34+ hematopoietic cells Blood, April 1, 2001; 97(7): 1951 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xiong, M. A. Luscher, J. D. Altman, M. Hulsey, H. L. Robinson, M. Ostrowski, B. H. Barber, and K. S. MacDonald Simian Immunodeficiency Virus (SIV) Infection of a Rhesus Macaque Induces SIV-Specific CD8+ T Cells with a Defect in Effector Function That Is Reversible on Extended Interleukin-2 Incubation J. Virol., March 15, 2001; 75(6): 3028 - 3033. [Abstract] [Full Text]
|
|
|
|
|
|
T. U. Vogel, T. M. Allen, J. D. Altman, and D. I. Watkins Functional Impairment of Simian Immunodeficiency Virus-Specific CD8+ T Cells during the Chronic Phase of Infection J. Virol., March 1, 2001; 75(5): 2458 - 2461. [Abstract] [Full Text]
|
|
|
|
|
|
D. H. Barouch, A. Craiu, S. Santra, M. A. Egan, J. E. Schmitz, M. J. Kuroda, T.-M. Fu, J.-H. Nam, L. S. Wyatt, M. A. Lifton, et al. Elicitation of High-Frequency Cytotoxic T-Lymphocyte Responses against both Dominant and Subdominant Simian-Human Immunodeficiency Virus Epitopes by DNA Vaccination of Rhesus Monkeys J. Virol., March 1, 2001; 75(5): 2462 - 2467. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Urvater, H. Hickman, J. L. Dzuris, K. Prilliman, T. M. Allen, K. J. Schwartz, D. Lorentzen, C. Shufflebotham, E. J. Collins, D. L. Neiffer, et al. Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2 J. Immunol., March 1, 2001; 166(5): 3334 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Allen, B. R. Mothé, J. Sidney, P. Jing, J. L. Dzuris, M. E. Liebl, T. U. Vogel, D. H. O'Connor, X. Wang, M. C. Wussow, et al. CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing J. Virol., January 15, 2001; 75(2): 738 - 749. [Abstract] [Full Text]
|
|
|
|
