| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
/ß and IL-18 Synergistically Enhance IFN-
Gene Expression in Human T Cells1
*
Department of Virology, National Public Health Institute, Helsinki, Finland; and
Fujisaki Institute, Hayashibara Biochemical Laboratories, Okayama, Japan
T cells contribute significantly the to host’s early defense
against viral and bacterial infections and are essential for clearance
of the pathogen. IFN-
, a product of activated T and NK cells, has,
in addition to its direct antimicrobial activity, a major role in
activating cell-mediated immunity. Here we report that cytokines
secreted by influenza A virus-infected macrophages are able to induce
IFN- synthesis in human T cells. Influenza A virus-infected human
peripheral macrophages secreted IFN-
/ß, TNF-, IL-1ß, and a
recently identified cytokine, IL-18 (or IFN--inducing factor),
whereas the production of IL-12 was not detected. Supernatants
collected from virus-infected macrophages induced rapid IFN- mRNA
expression and protein production in T cells. This was down-regulated
by the addition of neutralizing anti-IFN-/ß Abs, whereas
neutralizing anti-IL-12 Abs had no effect on IFN- gene
expression. Exogenously added IFN-/ß also rapidly stimulated the
synthesis of IFN- mRNA in T cells independently of protein
synthesis. IL-18 synergized with IFN- to up-regulate IFN- gene
expression and protein production. The data suggest that IFN-/ß
and IL-18 produced by macrophages during virus infection may act
together to induce IFN- synthesis and, consequently, may play an
important role for both of these cytokines in the development of
Th1-type immune responses.
This article has been cited by other articles:
|
|
 |
|
  M. Miettinen, V. Veckman, S. Latvala, T. Sareneva, S. Matikainen, and I. Julkunen Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages J. Leukoc. Biol., October 1, 2008; 84(4): 1092 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. de Boer, J. T. van Dissel, T. W. J. Kuijpers, G. F. Rimmelzwaan, F. P. Kroon, and T. H. M. Ottenhoff Influenza Virus Vaccination Induces Interleukin-12/23 Receptor {beta}1 (IL-12/23R{beta}1)-Independent Production of Gamma Interferon (IFN-{gamma}) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23R{beta}1 or IFN-{gamma} Receptor I Clin. Vaccine Immunol., August 1, 2008; 15(8): 1171 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Feld, V. M. Shpacovitch, C. Ehrhardt, C. Kerkhoff, M. D. Hollenberg, N. Vergnolle, S. Ludwig, and M. Steinhoff Agonists of Proteinase-Activated Receptor-2 Enhance IFN-{gamma}-Inducible Effects on Human Monocytes: Role in Influenza A Infection J. Immunol., May 15, 2008; 180(10): 6903 - 6910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Davis, K. A. Hagan, L. A. Matthews, G. Bajwa, M. A. Gill, M. Gale Jr., and J. D. Farrar Blockade of Virus Infection by Human CD4+ T Cells via a Cytokine Relay Network J. Immunol., May 15, 2008; 180(10): 6923 - 6932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Athie-Morales, G. M. O'Connor, and C. M. Gardiner Activation of Human NK Cells by the Bacterial Pathogen-Associated Molecular Pattern Muramyl Dipeptide J. Immunol., March 15, 2008; 180(6): 4082 - 4089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rintahaka, D. Wiik, P. E. Kovanen, H. Alenius, and S. Matikainen Cytosolic Antiviral RNA Recognition Pathway Activates Caspases 1 and 3 J. Immunol., February 1, 2008; 180(3): 1749 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pirhonen, J. Siren, I. Julkunen, and S. Matikainen IFN-{alpha} regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages J. Leukoc. Biol., November 1, 2007; 82(5): 1185 - 1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Ramos, A. M. Davis, T. C. George, and J. D. Farrar IFN-{alpha} Is Not Sufficient to Drive Th1 Development Due to Lack of Stable T-bet Expression J. Immunol., September 15, 2007; 179(6): 3792 - 3803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Carter A rationale for using steroids in the treatment of severe cases of H5N1 avian influenza J. Med. Microbiol., July 1, 2007; 56(7): 875 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Byrnes, D.-Y. Li, K. Park, D. Thompson, C. Mocilnikar, P. Mohan, J. P. Molleston, M. Narkewicz, H. Zhou, S. F. Wolf, et al. Modulation of the IL-12/IFN-{gamma} axis by IFN-{alpha} therapy for hepatitis C J. Leukoc. Biol., March 1, 2007; 81(3): 825 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O. Co, L. H. Hogan, J. Karman, E. Heninger, S. Vang, K. Wells, Y. Kawaoka, and M. Sandor Interactions between T Cells Responding to Concurrent Mycobacterial and Influenza Infections J. Immunol., December 15, 2006; 177(12): 8456 - 8465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K.-W. Hui, D. F. Smee, M.-H. Wong, and D. P. Nayak Mutations in Influenza Virus M1 CCHH, the Putative Zinc Finger Motif, Cause Attenuation in Mice and Protect Mice against Lethal Influenza Virus Infection. J. Virol., June 1, 2006; 80(12): 5697 - 5707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Pietila, V. Veckman, P. Kyllonen, K. Lahteenmaki, T. K. Korhonen, and I. Julkunen Activation, cytokine production, and intracellular survival of bacteria in Salmonella-infected human monocyte-derived macrophages and dendritic cells J. Leukoc. Biol., October 1, 2005; 78(4): 909 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Osterlund, V. Veckman, J. Siren, K. M. Klucher, J. Hiscott, S. Matikainen, and I. Julkunen Gene Expression and Antiviral Activity of Alpha/Beta Interferons and Interleukin-29 in Virus-Infected Human Myeloid Dendritic Cells J. Virol., August 1, 2005; 79(15): 9608 - 9617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tissari, J. Siren, S. Meri, I. Julkunen, and S. Matikainen IFN-{alpha} Enhances TLR3-Mediated Antiviral Cytokine Expression in Human Endothelial and Epithelial Cells by Up-Regulating TLR3 Expression J. Immunol., April 1, 2005; 174(7): 4289 - 4294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Siren, J. Pirhonen, I. Julkunen, and S. Matikainen IFN-{alpha} Regulates TLR-Dependent Gene Expression of IFN-{alpha}, IFN-{beta}, IL-28, and IL-29 J. Immunol., February 15, 2005; 174(4): 1932 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Stasakova, B. Ferko, C. Kittel, S. Sereinig, J. Romanova, H. Katinger, and A. Egorov Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1{beta} and 18 J. Gen. Virol., January 1, 2005; 86(1): 185 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Persky, K. M. Murphy, and J. D. Farrar IL-12, but Not IFN-{alpha}, Promotes STAT4 Activation and Th1 Development in Murine CD4+ T Cells Expressing a Chimeric Murine/Human Stat2 Gene J. Immunol., January 1, 2005; 174(1): 294 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Siren, T. Sareneva, J. Pirhonen, M. Strengell, V. Veckman, I. Julkunen, and S. Matikainen Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages J. Gen. Virol., August 1, 2004; 85(8): 2357 - 2364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Strengell, I. Julkunen, and S. Matikainen IFN-{alpha} regulates IL-21 and IL-21R expression in human NK and T cells J. Leukoc. Biol., August 1, 2004; 76(2): 416 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Rosenthal, L. D. Mikus, A. Tuffaha, A. G. Mosser, R. L. Sorkness, and R. F. Lemanske Jr. Attenuated Innate Mechanisms of Interferon-{gamma} Production in Rats Susceptible to Postviral Airway Dysfunction Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 702 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Marsland, N. L. Harris, M. Camberis, M. Kopf, S. M. Hook, and G. Le Gros Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells PNAS, April 20, 2004; 101(16): 6116 - 6121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Athie-Morales, H. H. Smits, D. A. Cantrell, and C. M. U. Hilkens Sustained IL-12 Signaling Is Required for Th1 Development J. Immunol., January 1, 2004; 172(1): 61 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Malmgaard and S. R. Paludan Interferon (IFN)-{alpha}/{beta}, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-{gamma} during infection with herpes simplex virus type 2 J. Gen. Virol., September 1, 2003; 84(9): 2497 - 2500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Gherardi, J. C. Ramirez, and M. Esteban IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system J. Gen. Virol., August 1, 2003; 84(8): 1961 - 1972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Strengell, S. Matikainen, J. Siren, A. Lehtonen, D. Foster, I. Julkunen, and T. Sareneva IL-21 in Synergy with IL-15 or IL-18 Enhances IFN-{gamma} Production in Human NK and T Cells J. Immunol., June 1, 2003; 170(11): 5464 - 5469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kambayashi, E. Assarsson, A. E. Lukacher, H.-G. Ljunggren, and P. E. Jensen Memory CD8+ T Cells Provide an Early Source of IFN-{gamma} J. Immunol., March 1, 2003; 170(5): 2399 - 2408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gracie, S. E. Robertson, and I. B. McInnes Interleukin-18 J. Leukoc. Biol., February 1, 2003; 73(2): 213 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lande, E. Giacomini, T. Grassi, M. E. Remoli, E. Iona, M. Miettinen, I. Julkunen, and E. M. Coccia IFN-{alpha}{beta} Released by Mycobacterium tuberculosis-Infected Human Dendritic Cells Induces the Expression of CXCL10: Selective Recruitment of NK and Activated T Cells J. Immunol., February 1, 2003; 170(3): 1174 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pirhonen, S. Matikainen, and I. Julkunen Regulation of Virus-Induced IL-12 and IL-23 Expression in Human Macrophages J. Immunol., November 15, 2002; 169(10): 5673 - 5678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Pien, K. B. Nguyen, L. Malmgaard, A. R. Satoskar, and C. A. Biron A Unique Mechanism for Innate Cytokine Promotion of T Cell Responses to Viral Infections J. Immunol., November 15, 2002; 169(10): 5827 - 5837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Strengell, T. Sareneva, D. Foster, I. Julkunen, and S. Matikainen IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response J. Immunol., October 1, 2002; 169(7): 3600 - 3605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. Nguyen, W. T. Watford, R. Salomon, S. R. Hofmann, G. C. Pien, A. Morinobu, M. Gadina, J. J. O'Shea, and C. A. Biron Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-gamma Response to Viral Infection Science, September 20, 2002; 297(5589): 2063 - 2066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Freudenberg, T. Merlin, C. Kalis, Y. Chvatchko, H. Stubig, and C. Galanos Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-{gamma} Induction by Gram-Negative Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling J. Immunol., August 15, 2002; 169(4): 1665 - 1668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Luft, M. Jefford, P. Luetjens, T. Toy, H. Hochrein, K.-A. Masterman, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E2 regulates the migratory capacity of specific DC subsets Blood, July 30, 2002; 100(4): 1362 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ariel, D. Novick, M. Rubinstein, C. A. Dinarello, O. Lider, and R. Hershkoviz IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components J. Leukoc. Biol., July 1, 2002; 72(1): 192 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Trobonjaca, A. Kroger, D. Stober, F. Leithauser, P. Moller, H. Hauser, R. Schirmbeck, and J. Reimann Activating Immunity in the Liver. II. IFN-{beta} Attenuates NK Cell-Dependent Liver Injury Triggered by Liver NKT Cell Activation J. Immunol., April 15, 2002; 168(8): 3763 - 3770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Brassard, M. J. Grace, and R. W. Bordens Interferon-{alpha} as an immunotherapeutic protein J. Leukoc. Biol., April 1, 2002; 71(4): 565 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Luft, P. Luetjens, H. Hochrein, T. Toy, K.-A. Masterman, M. Rizkalla, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky IFN-{alpha} enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells Int. Immunol., April 1, 2002; 14(4): 367 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Smits, E. C. de Jong, J. H. N. Schuitemaker, T. B. H. Geijtenbeek, Y. van Kooyk, M. L. Kapsenberg, and E. A. Wierenga Intercellular Adhesion Molecule-1/LFA-1 Ligation Favors Human Th1 Development J. Immunol., February 15, 2002; 168(4): 1710 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V M Salvati, T T MacDonald, M Bajaj-Elliott, M Borrelli, A Staiano, S Auricchio, R Troncone, and G Monteleone Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease Gut, February 1, 2002; 50(2): 186 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Jordan, R.-F. Guo, E. C. Yun, V. Sarma, R. L. Warner, L. D. Crouch, G. Senaldi, T. R. Ulich, and P. A. Ward Role of IL-18 in Acute Lung Inflammation J. Immunol., December 15, 2001; 167(12): 7060 - 7068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gigliotti Rothfuchs, D. Gigliotti, K. Palmblad, U. Andersson, H. Wigzell, and M. E. Rottenberg IFN-{alpha}{beta}-Dependent, IFN-{gamma} Secretion by Bone Marrow-Derived Macrophages Controls an Intracellular Bacterial Infection J. Immunol., December 1, 2001; 167(11): 6453 - 6461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ferko, J. Stasakova, S. Sereinig, J. Romanova, D. Katinger, B. Niebler, H. Katinger, and A. Egorov Hyperattenuated Recombinant Influenza A Virus Nonstructural-Protein-Encoding Vectors Induce Human Immunodeficiency Virus Type 1 Nef-Specific Systemic and Mucosal Immune Responses in Mice J. Virol., October 1, 2001; 75(19): 8899 - 8908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Giacomini, E. Iona, L. Ferroni, M. Miettinen, L. Fattorini, G. Orefici, I. Julkunen, and E. M. Coccia Infection of Human Macrophages and Dendritic Cells with Mycobacterium tuberculosis Induces a Differential Cytokine Gene Expression That Modulates T Cell Response J. Immunol., June 15, 2001; 166(12): 7033 - 7041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Mogensen and S. R. Paludan Molecular Pathways in Virus-Induced Cytokine Production Microbiol. Mol. Biol. Rev., March 1, 2001; 65(1): 131 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. D. Mikus, L. A. Rosenthal, R. L. Sorkness, and R. F. Lemanske Jr. Reduced Interferon-{gamma} Secretion by Natural Killer Cells from Rats Susceptible to Postviral Chronic Airway Dysfunction Am. J. Respir. Cell Mol. Biol., January 1, 2001; 24(1): 74 - 82. [Abstract] [Full Text]
|
|
|
|
|
|
L. Malmgaard, S. R. Paludan, S. C. Mogensen, and S. Ellermann-Eriksen Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-{kappa}B J. Gen. Virol., December 1, 2000; 81(12): 3011 - 3020. [Abstract] [Full Text]
|
|
|
|
|
|
G. C. Pien, A. R. Satoskar, K. Takeda, S. Akira, and C. A. Biron Cutting Edge: Selective IL-18 Requirements for Induction of Compartmental IFN-{gamma} Responses During Viral Infection J. Immunol., November 1, 2000; 165(9): 4787 - 4791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Riffault, C. Carrat, G. Milon, B. Charley, and J. H. Colle Transient IFN-{gamma} synthesis in the lymph node draining a dermal site loaded with UV-irradiated herpes simplex virus type 1: an NK- and CD3-dependent process regulated by IL-12 but not by IFN-{alpha}/{beta} J. Gen. Virol., October 1, 2000; 81(10): 2365 - 2373. [Abstract] [Full Text]
|
|
|
|
|
|
S. Oh and M. C. Eichelberger Polarization of Allogeneic T-Cell Responses by Influenza Virus-Infected Dendritic Cells J. Virol., September 1, 2000; 74(17): 7738 - 7744. [Abstract] [Full Text]
|
|
|
|
|
|
T. Sareneva, I. Julkunen, and S. Matikainen IFN-{alpha} and IL-12 Induce IL-18 Receptor Gene Expression in Human NK and T Cells J. Immunol., August 15, 2000; 165(4): 1933 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Verhagen, T. de Boer, H. H. Smits, F. A.W. Verreck, E. A. Wierenga, M. Kurimoto, D. A. Lammas, D. S. Kumararatne, O. Sanal, F. P. Kroon, et al. Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor {beta}1 (IL-12R{beta}1): Evidence for an IL-12R{beta}1-independent Pathway of IL-12 Responsiveness in Human T Cells J. Exp. Med., August 14, 2000; 192(4): 517 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Song, H.-J. Kim, J.-K. Park, J.-H. Lim, U.-O. Kim, J.-S. Kim, T.-H. Paik, K.-J. Kim, J.-W. Suhr, and E.-K. Jo Depressed Interleukin-12 (IL-12), but not IL-18, Production in Response to a 30- or 32-Kilodalton Mycobacterial Antigen in Patients with Active Pulmonary Tuberculosis Infect. Immun., August 1, 2000; 68(8): 4477 - 4484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Pinto, V. Blazevic, B. K. Patterson, C. Mac Trubey, M. J. Dolan, and G. M. Shearer Inhibition of Human Immunodeficiency Virus Type 1 Replication prior to Reverse Transcription by Influenza Virus Stimulation J. Virol., May 15, 2000; 74(10): 4505 - 4511. [Abstract] [Full Text]
|
|
|
|
|
|
M. Miettinen, A. Lehtonen, I. Julkunen, and S. Matikainen Lactobacilli and Streptococci Activate NF-{kappa}B and STAT Signaling Pathways in Human Macrophages J. Immunol., April 1, 2000; 164(7): 3733 - 3740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sing, T. Merlin, H.-P. Knopf, P. J. Nielsen, H. Loppnow, C. Galanos, and M. A. Freudenberg Bacterial Induction of Beta Interferon in Mice Is a Function of the Lipopolysaccharide Component Infect. Immun., March 1, 2000; 68(3): 1600 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Herbein and W. A. O'brien Tumor Necrosis Factor (TNF)-{alpha} and TNF Receptors in Viral Pathogenesis Experimental Biology and Medicine, March 1, 2000; 223(3): 241 - 257. [Abstract] [Full Text]
|
|
|
|
|
|
L. D. Giavedoni, M. C. Velasquillo, L. M. Parodi, G. B. Hubbard, and V. L. Hodara Cytokine Expression, Natural Killer Cell Activation, and Phenotypic Changes in Lymphoid Cells from Rhesus Macaques during Acute Infection with Pathogenic Simian Immunodeficiency Virus J. Virol., February 15, 2000; 74(4): 1648 - 1657. [Abstract] [Full Text]
|
|
|
|
|
|
A. Paananen, R. Mikkola, T. Sareneva, S. Matikainen, M. Andersson, I. Julkunen, M. S. Salkinoja-Salonen, and T. Timonen Inhibition of Human NK Cell Function by Valinomycin, a Toxin from Streptomyces griseus in Indoor Air Infect. Immun., January 1, 2000; 68(1): 165 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
