The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuklin, N. A.
Right arrow Articles by Rouse, B. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuklin, N. A.
Right arrow Articles by Rouse, B. T.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Herpes Simplex
The Journal of Immunology, 1998, 160: 5998-6003.
Copyright © 1998 by The American Association of Immunologists

Role of Mucosal Immunity in Herpes Simplex Virus Infection1

Nelly A. Kuklin, Massoud Daheshia, Sangjun Chun and Barry T. Rouse2

Department of Microbiology, University of Tennessee, Knoxville, TN 37996

This study evaluates whether the vaginal mucosal surface of immunized mice can prevent invasion by herpes simplex virus (HSV) and aims to identify immune components that affect immunity after challenge at the vaginal mucosa. Despite the induction of both IgA and IgG vaginal Ab following immunization with recombinant vaccinia virus vectors expressing either glycoproteins B or D, viral infection occurred in most animals even after minimal viral dose challenge. Challenged immune animals, including those genetically unable to generate anti-HSV Ab, survived and showed few if any clinical signs of infection. Experiments with T cell subtype knockout animals and depletion with T cell subset-specific MAb indicated that immunity following vaginal challenge was principally dependent on the function of CD4+ T cells. Our results indicate that anti-HSV vaccines may not provide barrier immunity at the vaginal mucosal site but may be adequate to minimize clinical expression of disease.




This article has been cited by other articles:


Home page
 JEMHome page
N. Iijima, M. M. Linehan, M. Zamora, D. Butkus, R. Dunn, M. R. Kehry, T. M. Laufer, and A. Iwasaki
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus
J. Exp. Med., December 22, 2008; 205(13): 3041 - 3052.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. J. Johnson, C.-F. Chu, and G. N. Milligan
Effector CD4+ T-Cell Involvement in Clearance of Infectious Herpes Simplex Virus Type 1 from Sensory Ganglia and Spinal Cords
J. Virol., October 1, 2008; 82(19): 9678 - 9688.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
I. Bettahi, A. B. Nesburn, S. Yoon, X. Zhang, A. Mohebbi, V. Sue, A. Vanderberg, S. L. Wechsler, and L. BenMohamed
Protective Immunity against Ocular Herpes Infection and Disease Induced by Highly Immunogenic Self-Adjuvanting Glycoprotein D Lipopeptide Vaccines
Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4643 - 4653.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. B. Nesburn, I. Bettahi, G. Dasgupta, A. A. Chentoufi, X. Zhang, S. You, N. Morishige, A. J. Wahlert, D. J. Brown, J. V. Jester, et al.
Functional Foxp3+ CD4+ CD25(Bright+) "Natural" Regulatory T Cells Are Abundant in Rabbit Conjunctiva and Suppress Virus-Specific CD4+ and CD8+ Effector T Cells during Ocular Herpes Infection
J. Virol., July 15, 2007; 81(14): 7647 - 7661.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. E. Dobbs, J. E. Strasser, C.-F. Chu, C. Chalk, and G. N. Milligan
Clearance of Herpes Simplex Virus Type 2 by CD8+ T Cells Requires Gamma Interferon and either Perforin- or Fas-Mediated Cytolytic Mechanisms
J. Virol., December 1, 2005; 79(23): 14546 - 14554.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. E. Gillgrass, S. A. Fernandez, K. L. Rosenthal, and C. Kaushic
Estradiol Regulates Susceptibility following Primary Exposure to Genital Herpes Simplex Virus Type 2, while Progesterone Induces Inflammation
J. Virol., March 1, 2005; 79(5): 3107 - 3116.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. E. Gillgrass, V. A. Tang, K. M. Towarnicki, K. L. Rosenthal, and C. Kaushic
Protection against Genital Herpes Infection in Mice Immunized under Different Hormonal Conditions Correlates with Induction of Vagina-Associated Lymphoid Tissue
J. Virol., March 1, 2005; 79(5): 3117 - 3126.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. A. Ashkar, S. Bauer, W. J. Mitchell, J. Vieira, and K. L. Rosenthal
Local Delivery of CpG Oligodeoxynucleotides Induces Rapid Changes in the Genital Mucosa and Inhibits Replication, but Not Entry, of Herpes Simplex Virus Type 2
J. Virol., August 15, 2003; 77(16): 8948 - 8956.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Kaushic, A. A. Ashkar, L. A. Reid, and K. L. Rosenthal
Progesterone Increases Susceptibility and Decreases Immune Responses to Genital Herpes Infection
J. Virol., April 15, 2003; 77(8): 4558 - 4565.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
D. M. Koelle and L. Corey
Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research
Clin. Microbiol. Rev., January 1, 2003; 16(1): 96 - 113.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. K. Eo, U. Kumaraguru, and B. T. Rouse
Plasmid DNA Encoding CCR7 Ligands Compensate for Dysfunctional CD8+ T Cell Responses by Effects on Dendritic Cells
J. Immunol., October 1, 2001; 167(7): 3592 - 3599.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. K. Eo, M. Gierynska, A. A. Kamar, and B. T. Rouse
Prime-Boost Immunization with DNA Vaccine: Mucosal Route of Administration Changes the Rules
J. Immunol., May 1, 2001; 166(9): 5473 - 5479.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
A. M. Harandi, B. Svennerholm, J. Holmgren, and K. Eriksson
Differential roles of B cells and IFN-{{gamma}}-secreting CD4+ T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice
J. Gen. Virol., April 1, 2001; 82(4): 845 - 853.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
N. A. Kuklin, L. Rott, N. Feng, M. E. Conner, N. Wagner, W. Muller, and H. B. Greenberg
Protective Intestinal Anti-Rotavirus B Cell Immunity Is Dependent on {{alpha}}4{{beta}}7 Integrin Expression But Does Not Require IgA Antibody Production
J. Immunol., February 1, 2001; 166(3): 1894 - 1902.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. K. Eo, S. Lee, S. Chun, and B. T. Rouse
Modulation of Immunity against Herpes Simplex Virus Infection via Mucosal Genetic Transfer of Plasmid DNA Encoding Chemokines
J. Virol., January 15, 2001; 75(2): 569 - 578.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
J.-I. Sin, J. J. Kim, C. Pachuk, C. Satishchandran, and D. B. Weiner
DNA Vaccines Encoding Interleukin-8 and RANTES Enhance Antigen-Specific Th1-Type CD4+ T-Cell-Mediated Protective Immunity against Herpes Simplex Virus Type 2 In Vivo
J. Virol., December 1, 2000; 74(23): 11173 - 11180.
[Abstract] [Full Text]

Home page
 Int ImmunolHome page
J.-I. Sin, V. Ayyavoo, J. Boyer, J. Kim, R. B. Ciccarelli, and D. B. Weiner
Protective immune correlates can segregate by vaccine type in a murine herpes model system
Int. Immunol., November 1, 1999; 11(11): 1763 - 1773.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.