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The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
Exogenously added IL-10 rapidly inhibited Staphylococcus
aureus- or LPS-induced cytokine mRNA expression in human PBMCs
and monocytes, with a maximal effect observed when IL-10 was added from
20 h before until 1 h after the addition of the inducers.
Nuclear run-on assays revealed that the inhibition of IL-12 p40, IL-12
p35, and TNF-
was at the gene transcriptional level and that the
addition of IL-10 to S. aureus- or LPS-treated PBMCs did
not affect mRNA stability. The inhibitory activity of IL-10 was
abrogated by cycloheximide (CHX), suggesting the involvement of a newly
synthesized protein(s). The addition of CHX at 2 h before S.
aureus or LPS also inhibited the accumulation of IL-12 p40 mRNA,
but did not inhibit IL-12 p35 and TNF- mRNA. This finding suggests
that p40 transcription is regulated through a de novo synthesized
protein factor(s), whereas the addition of CHX at 2 h after
S. aureus activation caused superinduction of the
IL-12 p40, IL-12 p35, and TNF-
genes. These results indicate that in human monocytes, the mechanism(s)
of IL-10 suppression of both IL-12 p40 and IL-12
p35 genes is primarily seen at the transcriptional level, and
that the induction of the IL-12 p40 and p35
genes have different requirements for de novo protein synthesis.
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H. Harizi, M. Juzan, V. Pitard, J.-F. Moreau, and N. Gualde Cyclooxygenase-2-Issued Prostaglandin E2 Enhances the Production of Endogenous IL-10, Which Down-Regulates Dendritic Cell Functions J. Immunol., March 1, 2002; 168(5): 2255 - 2263. [Abstract] [Full Text] [PDF]
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 M. G. Schwacha, C.-S. Chung, A. Ayala, K. I. Bland, and I. H. Chaudry Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury Am J Physiol Cell Physiol, February 1, 2002; 282(2): C263 - C270. [Abstract] [Full Text] [PDF]
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W. W. S. Kum, S. B. Cameron, R. W. Y. Hung, S. Kalyan, and A. W. Chow Temporal Sequence and Kinetics of Proinflammatory and Anti-Inflammatory Cytokine Secretion Induced by Toxic Shock Syndrome Toxin 1 in Human Peripheral Blood Mononuclear Cells Infect. Immun., December 1, 2001; 69(12): 7544 - 7549. [Abstract] [Full Text] [PDF]
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 K. Qadir, A. Metwali, A. M. Blum, J. Li, D. E. Elliott, and J. V. Weinstock TGF-beta and IL-10 regulation of IFN-gamma produced in Th2-type schistosome granulomas requires IL-12 Am J Physiol Gastrointest Liver Physiol, October 1, 2001; 281(4): G940 - G946. [Abstract] [Full Text] [PDF]
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I. B. McInnes, G. G. Illei, C. L. Danning, C. H. Yarboro, M. Crane, T. Kuroiwa, R. Schlimgen, E. Lee, B. Foster, D. Flemming, et al. IL-10 Improves Skin Disease and Modulates Endothelial Activation and Leukocyte Effector Function in Patients with Psoriatic Arthritis J. Immunol., October 1, 2001; 167(7): 4075 - 4082. [Abstract] [Full Text] [PDF]
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L. Crepaldi, S. Gasperini, J. A. Lapinet, F. Calzetti, C. Pinardi, Y. Liu, S. Zurawski, R. de Waal Malefyt, K. W. Moore, and M. A. Cassatella Up-Regulation of IL-10R1 Expression Is Required to Render Human Neutrophils Fully Responsive to IL-10 J. Immunol., August 15, 2001; 167(4): 2312 - 2322. [Abstract] [Full Text] [PDF]
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M. C. Braun, J. M. Wang, E. Lahey, R. L. Rabin, and B. L. Kelsall Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes Blood, June 1, 2001; 97(11): 3531 - 3536. [Abstract] [Full Text] [PDF]
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N. S. Ostlie, P. I. Karachunski, W. Wang, C. Monfardini, M. Kronenberg, and B. M. Conti-Fine Transgenic Expression of IL-10 in T Cells Facilitates Development of Experimental Myasthenia Gravis J. Immunol., April 15, 2001; 166(8): 4853 - 4862. [Abstract] [Full Text] [PDF]
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D. J. Berg, J. Zhang, D. M. Lauricella, and S. A. Moore IL-10 Is a Central Regulator of Cyclooxygenase-2 Expression and Prostaglandin Production J. Immunol., February 15, 2001; 166(4): 2674 - 2680. [Abstract] [Full Text] [PDF]
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L. Malmgaard, S. R. Paludan, S. C. Mogensen, and S. Ellermann-Eriksen Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-{kappa}B J. Gen. Virol., December 1, 2000; 81(12): 3011 - 3020. [Abstract] [Full Text]
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A. Boonstra, A. van Oudenaren, B. Barendregt, L. An, P. J. M. Leenen, and H. F. J. Savelkoul UVB irradiation modulates systemic immune responses by affecting cytokine production of antigen-presenting cells Int. Immunol., November 1, 2000; 12(11): 1531 - 1538. [Abstract] [Full Text] [PDF]
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X. Ma and L. J. Montaner Proinflammatory response and IL-12 expression in HIV-1 infection J. Leukoc. Biol., September 1, 2000; 68(3): 383 - 390. [Abstract] [Full Text] [PDF]
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I-M. Wang, C. Contursi, A. Masumi, X. Ma, G. Trinchieri, and K. Ozato An IFN-{gamma}-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages J. Immunol., July 1, 2000; 165(1): 271 - 279. [Abstract] [Full Text] [PDF]
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X. Wang, M. Chen, K. P. Wandinger, G. Williams, and S. Dhib-Jalbut IFN-{beta}-1b Inhibits IL-12 Production in Peripheral Blood Mononuclear Cells in an IL-10-Dependent Mechanism: Relevance to IFN-{beta}-1b Therapeutic Effects in Multiple Sclerosis J. Immunol., July 1, 2000; 165(1): 548 - 557. [Abstract] [Full Text] [PDF]
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J. Xiong, K. Kang, L. Liu, Y. Yoshida, K. D. Cooper, and M. A. Ghannoum Candida albicans and Candida krusei Differentially Induce Human Blood Mononuclear Cell Interleukin-12 and Gamma Interferon Production Infect. Immun., May 1, 2000; 68(5): 2464 - 2469. [Abstract] [Full Text] [PDF]
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G. Carra, F. Gerosa, and G. Trinchieri Biosynthesis and Posttranslational Regulation of Human IL-12 J. Immunol., May 1, 2000; 164(9): 4752 - 4761. [Abstract] [Full Text] [PDF]
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 H. Jyonouchi, S. Sun, and F. L. Rimell Cytokine Production by Sinus Lavage, Bronchial Lavage, and Blood Mononuclear Cells in Chronic Rhinosinusitis With or Without Atopy Arch Otolaryngol Head Neck Surg, April 1, 2000; 126(4): 522 - 528. [Abstract] [Full Text] [PDF]
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H. Jyonouchi, S. Sun, C. A. Kennedy, and F. L. Rimell Interferon Gamma Levels in the Sinus, Ear, and Airway in a Rabbit Sinusitis Model Induced by Bacteroides Inoculation Arch Otolaryngol Head Neck Surg, April 1, 2000; 126(4): 529 - 532. [Abstract] [Full Text] [PDF]
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H. Kanamori, S. Krieg, C. Mao, V. A. Di Pippo, S. Wang, D. A. Zajchowski, and D. J. Shapiro Proteinase Inhibitor 9, an Inhibitor of Granzyme B-mediated Apoptosis, Is a Primary Estrogen-inducible Gene in Human Liver Cells J. Biol. Chem., February 25, 2000; 275(8): 5867 - 5873. [Abstract] [Full Text] [PDF]
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X. Ma, J. Sun, E. Papasavvas, H. Riemann, S. Robertson, J. Marshall, R. T. Bailer, A. Moore, R. P. Donnelly, G. Trinchieri, et al. Inhibition of IL-12 Production in Human Monocyte-Derived Macrophages by TNF J. Immunol., February 15, 2000; 164(4): 1722 - 1729. [Abstract] [Full Text] [PDF]
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A. Aicher, G. L. Shu, D. Magaletti, T. Mulvania, A. Pezzutto, A. Craxton, and E. A. Clark Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells J. Immunol., December 1, 1999; 163(11): 5786 - 5795. [Abstract] [Full Text] [PDF]
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J. D. Marshall, J. Chehimi, G. Gri, J. R. Kostman, L. J. Montaner, and G. Trinchieri The Interleukin-12-Mediated Pathway of Immune Events Is Dysfunctional in Human Immunodeficiency Virus-Infected Individuals Blood, August 1, 1999; 94(3): 1003 - 1011. [Abstract] [Full Text] [PDF]
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J. S. Cowdery, N. J. Boerth, L. A. Norian, P. S. Myung, and G. A. Koretzky Differential Regulation of the IL-12 p40 Promoter and of p40 Secretion by CpG DNA and Lipopolysaccharide J. Immunol., June 1, 1999; 162(11): 6770 - 6775. [Abstract] [Full Text] [PDF]
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M. K. Levings and J. W. Schrader IL-4 Inhibits the Production of TNF-{alpha} and IL-12 by STAT6-Dependent and -Independent Mechanisms J. Immunol., May 1, 1999; 162(9): 5224 - 5229. [Abstract] [Full Text] [PDF]
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E. Yamaguchi, J. de Vries, and H. Yssel Differentiation of human single-positive fetal thymocytes in vitro into IL-4- and/or IFN-{gamma}-producing CD4+ and CD8+ T cells Int. Immunol., April 1, 1999; 11(4): 593 - 603. [Abstract] [Full Text] [PDF]
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J. M. Babik, E. Adams, Y. Tone, P. J. Fairchild, M. Tone, and H. Waldmann Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit J. Immunol., April 1, 1999; 162(7): 4069 - 4078. [Abstract] [Full Text] [PDF]
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R. Kishore, J. M. Tebo, M. Kolosov, and T. A. Hamilton Cutting Edge: Clustered AU-Rich Elements Are the Target of IL-10-Mediated mRNA Destabilization in Mouse Macrophages J. Immunol., March 1, 1999; 162(5): 2457 - 2461. [Abstract] [Full Text] [PDF]
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M. C. Braun, J. He, C.-Y. Wu, and B. L. Kelsall Cholera Toxin Suppresses Interleukin (IL)-12 Production and IL-12 Receptor {beta}1 and {beta}2 Chain Expression J. Exp. Med., February 1, 1999; 189(3): 541 - 552. [Abstract] [Full Text] [PDF]
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M. Delgado, E. J. Munoz-Elias, R. P. Gomariz, and D. Ganea Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Enhance IL-10 Production by Murine Macrophages: In Vitro and In Vivo Studies J. Immunol., February 1, 1999; 162(3): 1707 - 1716. [Abstract] [Full Text] [PDF]
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S. Sanjabi, A. Hoffmann, H.-C. Liou, D. Baltimore, and S. T. Smale Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages PNAS, November 7, 2000; 97(23): 12705 - 12710. [Abstract] [Full Text] [PDF]
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