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TVW Telethon Institute for Child Health Research, Divisions of Cell Biology and Children’s Leukaemia and Cancer Research, West Perth, Australia; and
Royal Perth Hospital, U.W.A., Department of Biochemistry, Laboratory of Cancer Medicine, Perth, Australia
Nitric oxide (NO) has been invoked as an important pathogenic factor in a wide range of immunologically mediated diseases. The present study demonstrates that macrophage-derived NO may conversely function to fine tune T cell-mediated inflammation via reversible dephosphorylation of intracellular signaling molecules, which are involved in the control of T cell proliferation. Thus, T cells activated in the presence of alveolar macrophages are unable to proliferate despite expression of IL-2R and secretion of IL-2. This process is reproduced by the NO generator S-nitroso-N-acetylpenicillamine and is inhibitable by the NO synthase inhibitor NG-methyl-L-arginine. Analysis of T cell lysates by immunoprecipitation with specific Abs and subsequent immunoblotting indicated marked reduction of tyrosine phosphorylation of Jak3 and STAT5 mediated by NO. Further studies indicated that NO-mediated T cell suppression was reversible by the guanylate cyclase inhibitors methylene blue and LY-83583 and was reproduced by a cell-permeable analogue of cyclic GMP, implicating guanylate cyclase activation as a key step in the inhibition of T cell activation by NO.
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|
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|
 |
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|
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S.-C. Lee, Z. H. Jaffar, K.-S. Wan, S. T. Holgate, and K. Roberts Regulation of Pulmonary T Cell Responses to Inhaled Antigen: Role in Th1- and Th2-Mediated Inflammation J. Immunol., June 1, 1999; 162(11): 6867 - 6879. [Abstract] [Full Text] [PDF]
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