| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Have Opposing Effects, While TGF-ß Positively Regulates Its Own Production
*
Lymphokine Regulation Unit and
Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and
Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
TGF-ß has been shown to play a central role in regulating
inflammatory responses; thus, understanding the factors involved in the
generation of TGF-ß-producing cells could lead to interventions that
are useful in effecting disease progression. In initial studies, the
capacity of naive CD4+ T cells from TCR transgenic
(Tg) mice to produce TGF-ß following primary and secondary
stimulation was assessed. TGF-ß, IL-4, or IFN-
production could
not be detected from highly purified naive CD4+/lymphocyte
endothelial cell adhesion molecule (LECAM)-1high cells
following primary stimulation for 36 h with plate-bound
anti-CD3, anti-CD28, and IL-2. This population was subsequently
used to study the differentiation of TGF-ß-producing CD4+
T cells. In further studies, naive
CD4+/LECAM-1high cells from TCR transgenic mice
of both the BALB/c and B10.A backgrounds were stimulated with
T-depleted spleen cells (TDS) and specific peptide in the presence of
various cytokines and/or cytokine antagonists for 5 days, restimulated,
and TGF-ß, IL-4, and IFN- production were measured. Priming
conditions favoring high IL-4 production and/or low IFN- production
greatly enhanced TGF-ß production in secondary cultures. Furthermore,
the presence of IL-10 in cultures was associated with an increase in
TGF-ß production following restimulation. The importance of IL-4 and
IFN- in regulating TGF-ß production was confirmed in studies
showing that cells from IFN--/- mice produced more
TGF-ß, while cells from IL-4-/- mice produced less
TGF-ß compared with wild-type controls. Finally, the addition of
exogenous TGF-ß to priming cultures significantly enhanced the
production of TGF-ß upon restimulation, demonstrating that TGF-ß
has a role in self-regulating its own production.
This article has been cited by other articles:
|
|
 |
|
  H. Takaki, K. Ichiyama, K. Koga, T. Chinen, G. Takaesu, Y. Sugiyama, S. Kato, A. Yoshimura, and T. Kobayashi STAT6 Inhibits TGF-{beta}1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor J. Biol. Chem., May 30, 2008; 283(22): 14955 - 14962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ho, C. C. Kurtz, M. Naganuma, P. B. Ernst, F. Cominelli, and J. Rivera-Nieves A CD8+/CD103high T Cell Subset Regulates TNF-Mediated Chronic Murine Ileitis J. Immunol., February 15, 2008; 180(4): 2573 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Zheng, J. Wang, P. Wang, J. D. Gray, and D. A. Horwitz IL-2 Is Essential for TGF-beta to Convert Naive CD4+CD25- Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells J. Immunol., February 15, 2007; 178(4): 2018 - 2027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Uss, A. T. Rowshani, B. Hooibrink, N. M. Lardy, R. A. W. van Lier, and I. J. M. ten Berge CD103 Is a Marker for Alloantigen-Induced Regulatory CD8+ T Cells. J. Immunol., September 1, 2006; 177(5): 2775 - 2783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Cheng, H.-W. Chen, J.-P. Tsai, Y.-P. Lee, Y.-C. Shih, C.-M. Chang, and C.-C. Ting Clonal restriction of the expansion of antigen-specific CD8+ memory T cells by transforming growth factor-{beta} J. Leukoc. Biol., May 1, 2006; 79(5): 1033 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kinjyo, H. Inoue, S. Hamano, S. Fukuyama, T. Yoshimura, K. Koga, H. Takaki, K. Himeno, G. Takaesu, T. Kobayashi, et al. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-{beta}1 J. Exp. Med., April 17, 2006; 203(4): 1021 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Kim, H. Y. Kim, S. Kim, J.-H. Chung, W. S. Park, and D. H. Chung Natural Killer T (NKT) Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis by Producing Interferon-{gamma} Am. J. Pathol., November 1, 2005; 167(5): 1231 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Favre, F. Spertini, and B. Corthesy Secretory IgA Possesses Intrinsic Modulatory Properties Stimulating Mucosal and Systemic Immune Responses J. Immunol., September 1, 2005; 175(5): 2793 - 2800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakamura, A. Terajewicz, and J. Stein-Streilein Mechanisms of Peripheral Tolerance following Intracameral Inoculation Are Independent of IL-13 or STAT6 J. Immunol., August 15, 2005; 175(4): 2643 - 2646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Y. Kim, H. J. Kim, H. S. Min, S. Kim, W. S. Park, S. H. Park, and D. H. Chung NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor {beta}1 production J. Exp. Med., January 3, 2005; 201(1): 41 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gunnlaugsdottir, S. M. Maggadottir, and B. R. Ludviksson Anti-CD28-induced co-stimulation and TCR avidity regulates the differential effect of TGF-{beta}1 on CD4+ and CD8+ naive human T-cells Int. Immunol., January 1, 2005; 17(1): 35 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lavelle, A. Jarnicki, E. McNeela, M. E. Armstrong, S. C. Higgins, O. Leavy, and K. H. G. Mills Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent J. Leukoc. Biol., May 1, 2004; 75(5): 756 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Anastasi, A. F. Campese, D. Bellavia, A. Bulotta, A. Balestri, M. Pascucci, S. Checquolo, R. Gradini, U. Lendahl, L. Frati, et al. Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes J. Immunol., November 1, 2003; 171(9): 4504 - 4511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lavelle, E. McNeela, M. E. Armstrong, O. Leavy, S. C. Higgins, and K. H. G. Mills Cholera Toxin Promotes the Induction of Regulatory T Cells Specific for Bystander Antigens by Modulating Dendritic Cell Activation J. Immunol., September 1, 2003; 171(5): 2384 - 2392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Singh, V. Saxena, S. Zang, L. Li, F. D. Finkelman, D. P. Witte, and C. O. Jacob Differential Contribution of IL-4 and STAT6 vs STAT4 to the Development of Lupus Nephritis J. Immunol., May 1, 2003; 170(9): 4818 - 4825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Huaux, T. Liu, B. McGarry, M. Ullenbruch, and S. H. Phan Dual Roles of IL-4 in Lung Injury and Fibrosis J. Immunol., February 15, 2003; 170(4): 2083 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sewell, Z. Qing, E. Reinke, D. Elliot, J. Weinstock, M. Sandor, and Z. Fabry Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization Int. Immunol., January 1, 2003; 15(1): 59 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chen, Y. Wei, G. C. Sharp, and H. Braley-Mullen Inhibition of TGF{beta}1 by Anti-TGF{beta}1 Antibody or Lisinopril Reduces Thyroid Fibrosis in Granulomatous Experimental Autoimmune Thyroiditis J. Immunol., December 1, 2002; 169(11): 6530 - 6538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Chang, S. Zhang, and M. H. Kaplan Neonatal Tolerance in the Absence of Stat4- and Stat6- Dependent Th Cell Differentiation J. Immunol., October 15, 2002; 169(8): 4124 - 4128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Zheng, J. D. Gray, K. Ohtsuka, S. Yamagiwa, and D. A. Horwitz Generation Ex Vivo of TGF-{beta}-Producing Regulatory T Cells from CD4+CD25- Precursors J. Immunol., October 15, 2002; 169(8): 4183 - 4189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kodera, T. L. McGaha, R. Phelps, W. E. Paul, and C. A. Bona Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts PNAS, March 19, 2002; 99(6): 3800 - 3805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Fuss, M. Boirivant, B. Lacy, and W. Strober The Interrelated Roles of TGF-{beta} and IL-10 in the Regulation of Experimental Colitis J. Immunol., January 15, 2002; 168(2): 900 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Dieu-Nosjean, C. Massacrier, B. Vanbervliet, W.-H. Fridman, and C. Caux IL-10 Induces CCR6 Expression During Langerhans Cell Development While IL-4 and IFN-{gamma} Suppress It J. Immunol., November 15, 2001; 167(10): 5594 - 5602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, W. Jin, H. Tian, P. Sicurello, M. Frank, J. M. Orenstein, and S. M. Wahl Requirement for Transforming Growth Factor {beta}1 in Controlling T Cell Apoptosis J. Exp. Med., August 20, 2001; 194(4): 439 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamagiwa, J. D. Gray, S. Hashimoto, and D. A. Horwitz A Role for TGF-{{beta}} in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood J. Immunol., June 15, 2001; 166(12): 7282 - 7289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Slavin, R. Maron, and H. L. Weiner Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes Int. Immunol., June 1, 2001; 13(6): 825 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Fry, E. Connick, J. Falloon, M. M. Lederman, D. J. Liewehr, J. Spritzler, S. M. Steinberg, L. V. Wood, R. Yarchoan, J. Zuckerman, et al. A potential role for interleukin-7 in T-cell homeostasis Blood, May 15, 2001; 97(10): 2983 - 2990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Levings, R. Sangregorio, F. Galbiati, S. Squadrone, R. de Waal Malefyt, and M.-G. Roncarolo IFN-{{alpha}} and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells J. Immunol., May 1, 2001; 166(9): 5530 - 5539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Ostlie, P. I. Karachunski, W. Wang, C. Monfardini, M. Kronenberg, and B. M. Conti-Fine Transgenic Expression of IL-10 in T Cells Facilitates Development of Experimental Myasthenia Gravis J. Immunol., April 15, 2001; 166(8): 4853 - 4862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Nogaki, E. Muso, I. Kobayashi, H. Kusano, K. Shirakawa, T. Kamata, A. Oyama, T. Ono, S. Miyawaki, H. Yoshida, et al. Interleukin 12 induces crescentic glomerular lesions in a high IgA strain of ddY mice, independently of changes in IgA deposition Nephrol. Dial. Transplant., August 1, 2000; 15(8): 1146 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. I. Karachunski, N. S. Ostlie, C. Monfardini, and B. M. Conti-Fine Absence of IFN-{gamma} or IL-12 Has Different Effects on Experimental Myasthenia Gravis in C57BL/6 Mice J. Immunol., May 15, 2000; 164(10): 5236 - 5244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kato and H. Nariuchi Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation J. Immunol., April 1, 2000; 164(7): 3554 - 3562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Gomes, C. R. Gattass, V. Barreto-de-Souza, M. E. Wilson, and G. A. DosReis TGF-{beta} Mediates CTLA-4 Suppression of Cellular Immunity in Murine Kalaazar J. Immunol., February 15, 2000; 164(4): 2001 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nishida and A. W. Taylor Specific Aqueous Humor Factors Induce Activation of Regulatory T Cells Invest. Ophthalmol. Vis. Sci., September 1, 1999; 40(10): 2268 - 2274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Liu, V. K. Kuchroo, and H. L. Weiner B7.2 (CD86) But Not B7.1 (CD80) Costimulation Is Required for the Induction of Low Dose Oral Tolerance J. Immunol., August 15, 1999; 163(4): 2284 - 2290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Bachmann, G. Kohler, B. Ecabert, T. W. Mak, and M. Kopf Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous J. Immunol., August 1, 1999; 163(3): 1128 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Gallichan, B. Balasa, J. D. Davies, and N. Sarvetnick Pancreatic IL-4 Expression Results in Islet-Reactive Th2 Cells That Inhibit Diabetogenic Lymphocytes in the Nonobese Diabetic Mouse J. Immunol., August 1, 1999; 163(3): 1696 - 1703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Marth, M. Zeitz, B. R. Ludviksson, W. Strober, and B. L. Kelsall Extinction of IL-12 Signaling Promotes Fas-Mediated Apoptosis of Antigen-Specific T Cells J. Immunol., June 15, 1999; 162(12): 7233 - 7240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Iwasaki and B. L. Kelsall I. Mucosal dendritic cells: their specialized role in initiating T cell responses Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1074 - G1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Shi, M. J. Grusby, and C. Nagler-Anderson Orally Induced Peripheral Nonresponsiveness Is Maintained in the Absence of Functional Th1 or Th2 Cells J. Immunol., May 1, 1999; 162(9): 5143 - 5148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Fallon and D. W. Dunne Tolerization of Mice to Schistosoma mansoni Egg Antigens Causes Elevated Type 1 and Diminished Type 2 Cytokine Responses and Increased Mortality in Acute Infection J. Immunol., April 1, 1999; 162(7): 4122 - 4132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Weiner Oral tolerance with Copolymer 1 for the treatment of multiple sclerosis PNAS, March 30, 1999; 96(7): 3333 - 3335. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rissoan, V. Soumelis, N. Kadowaki, G. Grouard, F. Briere, R. d. W. Malefyt, and Y. Liu Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation Science, February 19, 1999; 283(5405): 1183 - 1186. [Abstract] [Full Text]
|
|
|
|
|
|
M.-N. Kweon, K. Fujihashi, Y. Wakatsuki, T. Koga, M. Yamamoto, J. R. McGhee, and H. Kiyono Mucosally Induced Systemic T Cell Unresponsiveness to Ovalbumin Requires CD40 Ligand-CD40 Interactions J. Immunol., February 15, 1999; 162(4): 1904 - 1909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Braun, J. He, C.-Y. Wu, and B. L. Kelsall Cholera Toxin Suppresses Interleukin (IL)-12 Production and IL-12 Receptor {beta}1 and {beta}2 Chain Expression J. Exp. Med., February 1, 1999; 189(3): 541 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Seddon and D. Mason Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor {beta} and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC- Cells and CD4+CD8- Thymocytes J. Exp. Med., January 18, 1999; 189(2): 279 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Wu, H. Maeda, C. Contursi, K. Ozato, and R. A. Seder Differential Requirement of IFN Consensus Sequence Binding Protein for the Production of IL-12 and Induction of Th1-Type Cells in Response to IFN-{gamma} J. Immunol., January 15, 1999; 162(2): 807 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Wilson, B. M. Young, B. L. Davidson, K. A. Mente, and S. E. McGowan The Importance of TGF-{beta} in Murine Visceral Leishmaniasis J. Immunol., December 1, 1998; 161(11): 6148 - 6155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, W. Jin, and S. M. Wahl Engagement of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor {beta} (TGF-{beta}) Production by Murine CD4+ T Cells J. Exp. Med., November 16, 1998; 188(10): 1849 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.F. Neurath, B. Weigmann, S. Finotto, J. Glickman, E. Nieuwenhuis, H. Iijima, A. Mizoguchi, E. Mizoguchi, J. Mudter, P.R. Galle, et al. The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease J. Exp. Med., May 6, 2002; 195(9): 1129 - 1143. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
