| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,§,§,§,§,§
Departments of
*
Pathology and
Medicine, Harvard Medical School, Boston, MA 02115; and
Department of Pathology and the
§
Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA 02115
It is has been established that mouse mast cells (MCs) can reversibly alter their expression of serglycin proteoglycans and the homologous granule chymases that have been designated mouse MC protease (mMCP)-1, mMCP-2, and mMCP-5 in vivo. Nevertheless, it remained to be determined whether these immune cells could modify their expression of other chymases and the granule tryptases mMCP-6 and mMCP-7. As assessed immunohistochemically, we now show that MCs reversibly change their expression of the recently described chymase mMCP-9 and both tryptases as these cells traverse the jejunum during the amplification and regression stages of the reactive MC hyperplasia. In noninfected mice, most jejunal MCs reside in the submucosa and express mMCP-6 and mMCP-7, but not mMCP-9 or the chymase mMCP-2. During the inductive phase of the helminth-induced inflammation, when the jejunal MCs move from the submucosa to the tips of the villus, the MCs briefly express mMCP-9, cease expressing mMCP-6 and mMCP-7, and then express mMCP-2. During the recovery phase of the inflammation, jejunal MCs cease expressing mMCP-2 and then express varied combinations of mMCP-6, mMCP-7, and mMCP-9 as they move from the tips of the villus back toward the submucosa. In other model systems, mMCP-6 elicits neutrophil extravasation, and mMCP-7 regulates fibrin deposition and fibrinogen-mediated signaling events. Thus, the ability of a jejunal MC to reversibly alter its tryptase expression during an inflammatory event has important functional implications.
This article has been cited by other articles:
|
|
 |
|
  K. Shin, G. F. M. Watts, H. C. Oettgen, D. S. Friend, A. D. Pemberton, M. F. Gurish, and D. M. Lee Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection J. Immunol., April 1, 2008; 180(7): 4885 - 4891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Knight, A. B. Blazquez, S. Zhang, L. Mayer, H. A. Sampson, and M. C. Berin CD4 T cells activated in the mesenteric lymph node mediate gastrointestinal food allergy in mice Am J Physiol Gastrointest Liver Physiol, December 1, 2007; 293(6): G1234 - G1243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Knight, J. K. Brown, S. H. Wright, E. M. Thornton, J. A. Pate, and H. R.P. Miller Aberrant Mucosal Mast Cell Protease Expression in the Enteric Epithelium of Nematode-Infected Mice Lacking the Integrin {alpha}v{beta}6, a Transforming Growth Factor-{beta}1 Activator Am. J. Pathol., October 1, 2007; 171(4): 1237 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Demeure, K. Brahimi, F. Hacini, F. Marchand, R. Peronet, M. Huerre, P. St.-Mezard, J.-F. Nicolas, P. Brey, G. Delespesse, et al. Anopheles Mosquito Bites Activate Cutaneous Mast Cells Leading to a Local Inflammatory Response and Lymph Node Hyperplasia J. Immunol., April 1, 2005; 174(7): 3932 - 3940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Li, P. Zhou, Z. Petrin, and S. M. Singer Mast Cell-Dependent Control of Giardia lamblia Infections in Mice Infect. Immun., November 1, 2004; 72(11): 6642 - 6649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Knight, A. D. Pemberton, K. A. Robertson, D. J. Roy, S. H. Wright, and H. R. P. Miller Expression Profiling Reveals Novel Innate and Inflammatory Responses in the Jejunal Epithelial Compartment during Infection with Trichinella spiralis Infect. Immun., October 1, 2004; 72(10): 6076 - 6086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. De Jonge, A. De Laet, L. Van Nassauw, J. K. Brown, H. R. P. Miller, P.-P. van Bogaert, J.-P. Timmermans, and A. B. A. Kroese In vitro activation of murine DRG neurons by CGRP-mediated mucosal mast cell degranulation Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G178 - G191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Funaba, T. Ikeda, M. Murakami, K. Ogawa, K. Tsuchida, H. Sugino, and M. Abe Transcriptional Activation of Mouse Mast Cell Protease-7 by Activin and Transforming Growth Factor-{beta} Is Inhibited by Microphthalmia-associated Transcription Factor J. Biol. Chem., December 26, 2003; 278(52): 52032 - 52041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-W. Wang, H. P. McNeil, A. Husain, K. Liu, N. Tedla, P. S. Thomas, M. Raftery, G. C. King, Z. Y. Cai, and J. E. Hunt {delta} Tryptase Is Expressed in Multiple Human Tissues, and a Recombinant Form Has Proteolytic Activity J. Immunol., November 1, 2002; 169(9): 5145 - 5152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cenac, A.-M. Coelho, C. Nguyen, S. Compton, P. Andrade-Gordon, W. K. MacNaughton, J. L. Wallace, M. D. Hollenberg, N. W. Bunnett, R. Garcia-Villar, et al. Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2 Am. J. Pathol., November 1, 2002; 161(5): 1903 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Helmby and R. K. Grencis IL-18 Regulates Intestinal Mastocytosis and Th2 Cytokine Production Independently of IFN-{gamma} During Trichinella spiralis Infection J. Immunol., September 1, 2002; 169(5): 2553 - 2560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Kraneveld, H. P. M. van der Kleij, M. Kool, A. H. van Houwelingen, A. C. D. Weitenberg, F. A. M. Redegeld, and F. P. Nijkamp Key Role for Mast Cells in Nonatopic Asthma J. Immunol., August 15, 2002; 169(4): 2044 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Boyce, E. A. Mellor, B. Perkins, Y.-C. Lim, and F. W. Luscinskas Human mast cell progenitors use alpha 4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions Blood, April 15, 2002; 99(8): 2890 - 2896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, L. Li, R. Wadley, S. W. Reddel, J. C. Qi, C. Archis, A. Collins, E. Clark, M. Cooley, S. Kouts, et al. Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4 Blood, June 1, 2001; 97(11): 3484 - 3490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Bauer and E. Razin Mast Cell-Nerve Interactions Physiology, October 1, 2000; 15(5): 213 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Friend, M. F. Gurish, K. F. Austen, J. Hunt, and R. L. Stevens Senescent Jejunal Mast Cells and Eosinophils in the Mouse Preferentially Translocate to the Spleen and Draining Lymph Node, Respectively, During the Recovery Phase of Helminth Infection J. Immunol., July 1, 2000; 165(1): 344 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. O. Sanchez Mejia, B. K. Lam, and J. P. Arm Matrix-Associated Transforming Growth Factor-beta 1 Primes Mouse Bone Marrow-Derived Mast Cells for Increased High-Affinity Fc Receptor for Immunoglobulin E-Dependent Eicosanoid Biosynthesis Am. J. Respir. Cell Mol. Biol., May 1, 2000; 22(5): 557 - 565. [Abstract] [Full Text]
|
|
|
|
|
|
C. Huang, G. Morales, A. Vagi, K. Chanasyk, M. Ferrazzi, C. Burklow, W.-T. Qiu, E. Feyfant, A. Sali, and R. L. Stevens Formation of Enzymatically Active, Homotypic, and Heterotypic Tetramers of Mouse Mast Cell Tryptases. DEPENDENCE ON A CONSERVED Trp-RICH DOMAIN ON THE SURFACE J. Biol. Chem., January 7, 2000; 275(1): 351 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Razin, Z. C. Zhang, H. Nechushtan, S. Frenkel, Y.-N. Lee, R. Arudchandran, and J. Rivera Suppression of Microphthalmia Transcriptional Activity by Its Association with Protein Kinase C-interacting Protein 1 in Mast Cells J. Biol. Chem., November 26, 1999; 274(48): 34272 - 34276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Wong, Y. Tang, E. Feyfant, L. Li, Y. Li, C. Huang, D. S. Friend, S. A. Krilis, and R. L. Stevens Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension J. Biol. Chem., October 22, 1999; 274(43): 30784 - 30793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R.P. Miller, S. H. Wright, P. A. Knight, and E. M. Thornton A Novel Function for Transforming Growth Factor-{beta}1: Upregulation of the Expression and the IgE-Independent Extracellular Release of a Mucosal Mast Cell Granule-Specific {beta}-Chymase, Mouse Mast Cell Protease-1 Blood, May 15, 1999; 93(10): 3473 - 3486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Valchanov and G. B. Proctor Enzyme Histochemistry of Tryptase in Stomach Mucosal Mast Cells of the Mouse J. Histochem. Cytochem., May 1, 1999; 47(5): 617 - 622. [Abstract] [Full Text]
|
|
|
|
|
|
A. R. Rosenkranz, A. Coxon, M. Maurer, M. F. Gurish, K. F. Austen, D. S. Friend, S. J. Galli, and T. N. Mayadas Cutting Edge: Impaired Mast Cell Development and Innate Immunity in Mac-1 (CD11b/CD18, CR3)-Deficient Mice J. Immunol., December 15, 1998; 161(12): 6463 - 6467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, Y. Li, S. W. Reddel, M. Cherrian, D. S. Friend, R. L. Stevens, and S. A. Krilis Identification of Basophilic Cells that Express Mast Cell Granule Proteases in the Peripheral Blood of Asthma, Allergy, and Drug-Reactive Patients J. Immunol., November 1, 1998; 161(9): 5079 - 5086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Wong, S. Yasuda, M. S. Madhusudhan, L. Li, Y. Yang, S. A. Krilis, A. Sali, and R. L. Stevens Human Tryptase epsilon (PRSS22), a New Member of the Chromosome 16p13.3 Family of Human Serine Proteases Expressed in Airway Epithelial Cells J. Biol. Chem., December 28, 2001; 276(52): 49169 - 49182. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
