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The Journal of Immunology, 1998, 160: 5448-5454.
Copyright © 1998 by The American Association of Immunologists

Fas Ligand-Induced Apoptosis of Infected Human Macrophages Reduces the Viability of Intracellular Mycobacterium tuberculosis1

Mauro Oddo*, Toufic Renno{ddagger}, Antoine Attinger{ddagger}, Talitha Bakker{ddagger}, H. Robson MacDonald{ddagger} and Pascal R. A. Meylan2,*,{dagger}

* Institute of Microbiology and {dagger} Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; and {ddagger} Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland

Mycobacterium tuberculosis-specific cytolytic activity is mediated mostly by CD4+CTL in humans. CD4+CTL kill infected target cells by inducing Fas (APO-1/CD95)-mediated apoptosis. We have examined the effect of Fas ligand (FasL)-induced apoptosis of human macrophages infected in vitro with M. tuberculosis on the viability of the intracellular bacilli. Human macrophages expressed Fas and underwent apoptosis after incubation with soluble recombinant FasL. In macrophages infected either with an attenuated (H37Ra) or with a virulent (H37Rv) strain of M. tuberculosis, the apoptotic death of macrophages was associated with a substantial reduction in bacillary viability. TNF-induced apoptosis of infected macrophages was coupled with a similar reduction in mycobacterial viability, while the induction of nonapoptotic complement-induced cell death had no effect on bacterial viable counts. Infected macrophages also showed a reduced susceptibility to FasL-induced apoptosis correlating with a reduced level of Fas expression. These data suggest that apoptosis of infected macrophages induced through receptors of the TNF family could be an immune effector mechanism not only depriving mycobacteria from their growth environment but also reducing viable bacterial counts by an unknown mechanism. On the other hand, interference by M. tuberculosis with the FasL system might represent an escape mechanism of the bacteria attempting to evade the effect of apoptosis.




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